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37篇 您的检索式：作者名="Shi DR"

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	题名	作者	年代	出处	被引量
1	Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature显示文摘Steroid 5β-reductase [aldo-keto reductase family 1 member D1(AKR1D1)] is essential for bile acid biosynthesis. Bile acid deficiency caused by genetic defects in AKR1D1 leads to life-threatening neonatal hepatitis and cholestasis. There is still limited experience regarding the treatment of this disease. We describe an infant who presented with hyperbilirubinemia and coagulopathy but normal bile acid and γ-glutamyltransferase. Gene analysis was performed using genomic DNA from peripheral lymphocytes from the patient, his parents, and his elder brother. The patient was compound heterozygous for c.919C>T in exon 8 and exhibited a loss of heterozygosity of the AKR1D1 gene, which led to an amino acid substitution of arginine by cysteine at amino acid position 307(p.R307C). Based on these mutations, the patient was confirmed to have primary 5β-reductase deficiency. Ursodeoxycholic acid(UDCA) treatment did not have any effect on the patient. However, when we changed to chenodeoxycholic acid(CDCA) treatment, his symptoms and laboratory tests gradually improved. It is therefore crucial to supplement with an adequate dose of CDCA early to improve clinical symptoms and to normalize laboratory tests.	Hui-Hui Wang Fei-Qiu Wen Dong-Ling Dai Jian-She Wang Jing Zhao Kenneth DR Setchell Li-Na Shi Shao-Ming Zhou Si-Xi Liu Qing-Hua Yang	2018	World Journal of Gastroenterology2018，24，35：	3
2	Inhibition of the interferon- inducible protein kinase PKR by HCV E2 protein显示文摘	Taylor DR Shi ST Romano PR	1999	Science1999，285，：	1
3	Identification of apolipo- protein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease显示文摘	Tsukamoto K Mani DR Shi J	2013	Proc Natl Acad Sci USA2013，110，17：	1
4	Study of prognostic predictors for non- small cell lung cancer显示文摘	Fu XL Zhu XZ Shi DR	1999	Lung Cancer1999，23，2：	1
5	Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis:correlations with adult intestinal epithelial differentiation during metamorphosis显示文摘	Buchholz DR Ishizuya-Oka A Shi YB	2004	Gene Expr Patterns2004，4，3：	1
6	Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis:correlations with adult in testinal epithelial differentiation during metamorphosis显示文摘	Buchholz DR Ishizuya-Oka A Shi YB	2004	Gene Expr Patterns2004，4，3：	1
7	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment显示文摘	Bai F Watson DR Shi Y	2011	PLoS One2011，6，24：	1
8	Expression of anaplastic lymphoma kinase in soft tissue tumors: an immunohistochemical andmolecular study of 249 cases显示文摘	Li XQ Hisaoka M Shi DR	2004	Hum Pathol2004，35，6：	1
9	Preferential Humoral Immune Response in Prostate Cancer to Cellular Proteins p90 and p62 in a Panel of Tumor-Associated Antigens 显示文摘	Shi FD Zhang JY Liu DR	2005	Prostate2005，63，3：	1
10	Study of prognostic predictors for non small cell lung cancer 显示文摘	Fu XL Zhu XZ Shi DR	1999	Lung Cancer1999，23，2：	1
11	Recombinant protein expression in Pichia pastoris 显示文摘	Cregg JM Cereghino JL Shi J Higgins DR	2000	Molecular Biotechnology2000，，：	1
12	Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein显示文摘	Taylor DR Shi ST Romano PR	1999	Science1999，285，5424：	1
13	Simple sequence re-peat-based consensus linkage map of Bombyx mori显示文摘	Miao XX Xu SJ Li MH Li MW Huang JH Dai FY Marino SW Mills DR Zeng P Mita K Jia SH Zhang Y Liu WB Xiang H Guo QH Xu AY Kong XY Lin HX Shi YZ Lu G Zhang X Huang W Yasukochi Y Sugasaki T Shimada T Nagaraju J Xiang ZH Wang SY Goldsmith MR Lu C Zhao GP Huang YP	2005	Proc Natl Acad Sci USA2005，102，16：	1
14	Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment显示文摘	Bai F Watson DR Shi Y	2011	PLoS One2011，6，24：	1
15	Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnauometer resolution reveals alpha helices and insight into DNA binding显示文摘	Williams DR Lee KJ Shi J	2008	Structure2008，16，3：	1
16	An Efficient Protocol for Anonymous and Fair Document Exchange显示文摘	Dr N Zhang Q Shi	2003	Computer Network Journal Elsevier Science Publisher2003，41，1：	1
17	Focused evolution of HIV-1 neu- tralizing antibodies revealed by structures and deep sequen- cing显示文摘	Wu X Zhou T Zhu J Zhang B Georgiev I Wang C Chen X Longo NS Louder M MeKee K O'Dell S Perfet- to S Schmidt SD Shi W Wu L Yang Y Yang ZY Yang Z Zhang Z Bonsignori M Crump JA Kapiga SH Sam NE Haynes BF Simek M Burton DR Koff WC Doria- Rose NA Connors M NISC Comparative Sequencing Pro- gram Mullikin JC Nabel GJ Roederer M Shapiro L Kwong PD Mascola JR	2011	Science2011，333，6049：	1
18	Study of prognostic predictors for non-small cell lung cancer 显示文摘	Fu XL Zhu XZ Shi DR	1999	Lung Cancer1999，23，2：	1
19	Three new diterpenoids from Leonurus japonieus 显示文摘	Liu ZK Wu DR Shi YM	2014	Chin Chem Lett2014，25，：	1
20	Inhibition of the interferon -inducible protein kinase PKR by HCV E2 protein 显示文摘	Taylor DR Shi ST Romano PR	1999	Science1999，285，5424：	1

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