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| 1 | P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy显示文摘Current estimates indicate that the hepatitis C(HCV)is the leading cause of mortality around the world,with infection rates steadily increasing in Egypt.The dual therapy for this silent epidemic with pegylated-interferon-a2b/ribavirin has markedly improved the success rates in genotype-4 patients.It was reported that apoptosis plays a vital mechanistic role in limiting viral replication.P53,a key regulator of apoptosis,induces CD95 gene expression and subsequently initiates apoptotic cascade to be activated.The current study examined the impact of P53 rs1042522 and CD95 rs1800682 polymorphisms on the treatment response.Three groups of 240 volunteers were enrolled in this study;86 in sustained virological responders group,74 in non-responders group,and 80 in control group.All patients had HCV genotype-4a and were interferon treatment naı¨ve.Quantizations of HCV-RNA by qRT-PCR and histological scores were performed for all patients.In addition,genotyping of HCV-RNA,P53 rs1042522 Arg/Pro and CD95 rs1800682 A/G polymorphisms were investigated in all subjects.It was resulted that P53 Pro/Pro homozygous genotype has high significant increase,while CD95 A/A homozygous genotype has high significant decrease when comparing non-responders with responders.Finally,it was concluded that Pro variant of P53 rs1042522 may be used as a genetic predictor for non-responsiveness,while A/A variant of CD95 rs1800682 may be used as a sensitive biomarker for responsiveness to antiviral therapy of HCV genotype-4a infection.In addition,low prolactin,high total testosterone,and high GH levels may provide promising biomarkers for early prediction of the response when associated with these genetic polymorphisms. | Ahmed A.Abd-Rabou Emad F.Eskander Mervat S.Mohamed Shaymaa M.M.Yahya Ashraf El Sherbini Olfat G.Shaker | 2015 | Genes & Diseases2015，2，2： | 1 |
| 2 | Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer显示文摘 | E1 Sherbini MA Sallam MM Shaban EA | | 0，，04： | 1 |
| 3 | Estimation of the effective dons when protective aprons are used in medical procodures:a theoretical evaluation of several methods显示文摘 | Sherbini S DeCicco J | 2002 | Health Phys2002，83，6： | 1 |
| 4 | Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent显示文摘 | EL- SHERBINY D EL- ENANY N BELA F | 2007 | Pharm Biomed Anal2007，43，4： | 1 |
| 5 | Qualitative and quantiative evaluation of aerobic microflora of the colon in bilharzial patients before and after praziquantel therapy 显示文摘 | Mokhtar S Behairr N sherbini E | 1988 | Egyptian J Bihaziasis1988，10，1： | 1 |
| 6 | Treatment of urethral defeces: skin, buccal or bladder mucosa, tube or patch? An experimental study in dogs 显示文摘 | El- sherbiny MT Abol- Enein H Dawaba MS | 2002 | J Urol2002，167，5： | 1 |
| 7 | Placental protein 13 as an early predictor in Egyptian patients with preeclampsia, correlation to risk, and association with outcome显示文摘 | Sherbiny W S E Ahmed S Nasr A S | 2012 | Journal of Investigative Medicine the Official Publication of the American Federation for Clinical Research2012，60，5： | 1 |
| 8 | Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer 显示文摘 | E1 Sherbini MA Sallam MM Shaban EA | 2011 | Int J Gynaecol Cancer2011，21，4： | 1 |
| 9 | Temperature Distributions andThermal Distortions of Brake Drums显示文摘 | Ashworth R J Sherbiny M E L | 1977 | Proc I Mech E1977，，191： | 1 |
| 10 | Qualitative and quantitative evaluation of aerobic microflora of the colon in biharzial patients before and after praziquantel therapy 显示文摘 | Mokhtar S Behairr N Sherbini E | 1998 | Egyptian J Bilhaziesis1998，10，1： | 1 |
| 11 | Ionotropically crosslinked p H-sensitive IPN hydrogel matrices as potential carriers for intestine-specific oral delivery of protein drugs显示文摘 | SHERBINY I M SALAMA A SARHAN A A | 2011 | Drug Dev Ind Pharm2011，37，2： | 1 |
| 12 | Diagonstic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cacer 显示文摘 | EI Sherbini M A Sallam M M Shaban E A | 2011 | Int J Gynecol Cancer2011，21，4： | 1 |
| 13 | Evaluation of the use of microemulsions as eluents in high- performance liquid chromatography显示文摘 | EL - SHERBINY D EL - ASHRY S MUSTAFA M | 2003 | J Sep Sci2003，26，67： | 1 |
| 14 | Qualitative and quantitative evaluation of aerobic microflora of the colon in bilharzial patients before and after praziquantel therapy显示文摘 | Mokhtar S Behairr N sherbini E | 1988 | Egyptian J Bihaziasis1988，10，1： | 1 |
| 15 | Problems of invert sugar as food for honeybees显示文摘 | Jachimowicz T Sherbiny G | 1975 | Apidologie1975，6，2： | 1 |
| 16 | Thinning and Spring Back Prediction of Sheet Metal in the Deep Drawing Process 显示文摘 | ZEIN H EL SHERBINY M ABD-RABOU M | 2014 | Materials & Design2014，53，： | 1 |
| 17 | Preparation and Properties of Some Chemical and Electrochemical γ-MnO_2显示文摘Chemically prepared electrolytic 2-Mn02 and an electrodeposited MnO2 doped with Ce(Ⅲ) were subjected to physicochemical studies. X-ray diffractometry, density measurements, chem-ical analysis and thermal analysis were used to determine the structure and chemical disorder present. The samples prepared chemically (CMD) or electrochemically (EMD) showed a variable amount of de Wolff disorder (Pr) and microtwinning (Tw). Manganese dioxide prepared in the presence of Ce(Ⅲ) showed appreciable decrease in de Wolff defect and a large amount of microtwinning. Thermal analysis showed a loss of weight due to the physically adsorbed and the structural (OH) water, from which the activation energy was calculated. Chemical composition and formulae calculated on the bases of cation vacancy model, cleared that Ce(lIl)-doped sample has a remarkable increase in the vacancies population associated with higher structural water content. This leads to lower activation energy of water release, and consequently it is supposed to acquire higher electrochemical activity. | H.M.Abbas, Kh. S.Abou-El-Sherbini, M.H.Askar and A. M. Hashim Dept.of Physical Centre, National Research Centre, Tahiu, Dokki, Cairo, Egypt E-mail: sherbini@yahoo.com | 2001 | Journal of Materials Science & Technology2001，17，3： | 1 |
| 18 | Subendometrial blood flow changes by 3-dimensional power doppler ultrasound after hysteroscopic lysis of severe intrauterine adhesions: Preliminary study显示文摘 | Mohamed Amer MI Omar OH E1 Sherbiny Hamed M | 2015 | Journal of minimally invasive gynecology2015，22，3： | 1 |
| 19 | Subendometrial blood flow changes by 3-dimensional power Doppler ultrasound after hysteroscopic lysis of severe intrauterine adhesions:preliminary study显示文摘 | Mohamed Amer MI Omar OH El Sherbiny Hamed M | 2015 | J Minim Invasive Gynecol2015，22，3： | 1 |
| 20 | Simultane ous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatogra- phy with a microemulsion as eluent显示文摘 | Sherbiny D T Enany N Belal F F | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，43，： | 1 |
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