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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 3 | Spacecraft Navigation Using X-ray Pulsars 显示文摘 | Sheikh S I Pines D J Ray P S | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 4 | Stiffened steel plates under combined compression and bending 显示文摘 | Sheikh I A Elwi A E Grondin G Y | 2003 | Journal of Constructional Steel Research2003，59，： | 1 |
| 5 | Hepatitis C virus infection: molecular pathways to metabolic syndrome 显示文摘 | Sheikh MY Choi J Qadri I | 2008 | Hepatology2008，47，6： | 1 |
| 6 | Tainted blood: Probing safety practices in the Danish blood system 显示文摘 | Deleuran I Sheikh ZA Hoeyer K | 2015 | Health (London)2015，19，5： | 1 |
| 7 | Spacecraft navigation using X-ray pulsars显示文摘 | Sheikh S I Pines D J | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 8 | The development of live load for long span bridges显示文摘 | Nowak A S Lutomirska M Sheikh Ibrahim F I | 2010 | Bridge Structures-Assessment Design&Construction2010，6，1： | 1 |
| 9 | Role of cyanide production by Pseudomonas fluorescens CHA0 in the suppression of root-knot nematodes, Meloidogyne javanica in tomato显示文摘 | Siddiqui I A Shaukat S S Sheikh I H | 2006 | World Journal of Microbiology & Biotechnology2006，26，： | 1 |
| 10 | Role of ultrasonography in blunt abdominal trauma,a prospective study显示文摘 | Al-Zayat I Sheikh M Mousa I Behbe-hani A | 1996 | Eur J Surg1996，162，： | 1 |
| 11 | Recursive estimation of spacecraft position and velocity using X-ray pulsar time of arrival measurements显示文摘 | Sheikh S I Pines D J | 2006 | Navigation Journal of the Institute of Navigation2006，53，3： | 1 |
| 12 | Hepatitis C virus infection: molecular pathways to metabolic syndrome显示文摘 | Sheikh MY Choi J Qadri I | 2008 | Hepatology2008，47，6： | 1 |
| 13 | The use of x-ray pulsars for spacecraft navigation显示文摘 | Sheikh S I pinesDJ RayPS | 2005 | Advances in the Astrauautical Science2005，119，： | 1 |
| 14 | Spacecraft navigation using X-ray pulsars 显示文摘 | Sheikh S I Pines D J Ray P S | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 15 | Reconstructing sibling relationships in wild populations显示文摘 | Bergcr-Wolf T Y Sheikh S I | 2007 | Bioinformatics2007，23，13： | 1 |
| 16 | Spacecraft navigation using x-ray pulsars显示文摘 | Sheikh S I Pines D J Ray P S | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 17 | Computational e- valuation and experimental in vitro antibacterial, antifungal and antiviral activity of bis-Schiff bases of isatin and its derivatives显示文摘 | Jarrahpour A Sheikh J Mounsi I E | 2013 | Med Chem Res2013，22，3： | 1 |
| 18 | The use of x-ray pulsars for spacecraft navigation 显示文摘 | Suneel I Sheikh Darryll J Pines Paul S Ray | 2005 | Advances in the Astronautical Science2005，119，： | 1 |
| 19 | Spacecraft navigation using X-ray pulsars 显示文摘 | Sheikh S I Pines D J Bay P S | 2006 | Journal of Guidance Control and Dynamics2006，29，： | 1 |
| 20 | Spacecraft Navigation Using X-ray Pulsars显示文摘 | Sheikh S I Darryll J P | | 0，，01： | 1 |
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