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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 3 | Production of hydrogen from chemical hydrides via hydrolysis with steam 显示文摘 | AIELLO R SHARP J H MATTHEWS M A | 1999 | International Journal of Hydrogen Energy1999，24，12： | 1 |
| 4 | The production of elastic waves by explosion pressures: Ⅰ, Theory and empirical observations显示文摘 | Sharpe J A | 1942 | Geophysics1942，7，： | 1 |
| 5 | Case study:a state space condition monitoring model for furnace erosion prediction and replacement显示文摘 | Christer A H Wang W Sharp J M | 1997 | European Journal of Operational Research1997，101，1： | 1 |
| 6 | A state space condition monitoring model for furnace erosion prediction and replacement显示文摘 | Christer A H Wang W Sharp J M | 1997 | European Journal of Operational Research1997，101，1： | 1 |
| 7 | Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study显示文摘 | Zheng Ye Stephen J Sharp Stephen Burgess Robert A Scott Fumiaki Imamura Claudia Langenberg Nicholas J Wareham Nita G Forouhi | 2015 | The Lancet Diabetes & Endocrinology2015，，1： | 1 |
| 8 | Homoeologous loci control the accumulation of seed glucosinolates in oilseed rape (Brassica napus)显示文摘 | HOWELL P M SHARPE A G LYDIATE D J | 2003 | Genome2003，46，： | 1 |
| 9 | The BT-CD28 superfamily显示文摘 | SHARPE A H FREEMAN G J | 2002 | Nat Rev Immunol2002，2，： | 1 |
| 10 | A problem in age distribution显示文摘 | Sharpe F R Lotka A J | 1911 | Phi Mag1911，21，6： | 1 |
| 11 | Determination of the isotopic composition ofammonium-nitrogen at the natural abundance level fromestuarine waters 显示文摘 | Velinsky D J Pennock J R Sharp J H Cifuentes L A Fogel M L | 1989 | Marine Chemistry1989，26，： | 1 |
| 12 | Chlorine isotope homogeneity of the mantle, crust andcarbonaceous chondrites 显示文摘 | Sharp Z D Barnes J D Brearley A J | 2007 | Nature2007，446，7139： | 1 |
| 13 | Negative co-receptors on lymphocytes显示文摘 | Greenwald R J Latchman Y E Sharpe A H | 2002 | Curr Opin Immunol2002，14，3： | 1 |
| 14 | siRNAs can function as miRNAs显示文摘 | Doench J G Petersen C P Sharp P A | | 0，，04： | 1 |
| 15 | FRVT 2006 and ICE 2006 large-scale ex- perimental results显示文摘 | Phillips P J Scruggs T O'Toole A Flynn P J Bowyer K W Sehott C Sharpe M | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，5： | 1 |
| 16 | The B7 family revisited显示文摘 | Greenwald R J Freeman G J Sharpe A H | 2005 | Annu Rev Immunol2005，23，： | 1 |
| 17 | Improved Aerobic Col- ony Count Technique for Hydrophobic Grid Membrane Filters 显示文摘 | Parrington L J Sharpe A N Peterkin P I | 1993 | Applied and Environmental Microbiology1993，59，9： | 1 |
| 18 | The B7 family revis ited显示文摘 | Greenwald R J Freeman G J Sharpe A H | 2005 | Annu Rev Immunol2005，23，： | 1 |
| 19 | A direct instrument comparison for measurement of total dissolved nitrogen in seawater显示文摘 | SHARP J H BEAUREGARD A Y BURDIGE D | 2004 | Marine Chemistry2004，84，： | 1 |
| 20 | Thaumasite formationin Portland-limestone cement pastes 显示文摘 | HARTSHORN S A SHARP J H SWAMY R N | 1999 | Cem Concr Res1999，29，： | 1 |
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