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| 1 | Closed reduction and internal fixation versus total hip arthroplasty for displaced femoral neck fracture显示文摘ObjectiveTo 为代替的大腿骨的颈 fracture.MethodsIn 比较在关上的减小和内部固定和全部的新潮的关节造形术(THA )(CRIF ) 之间的临床的效果这未来的使随机化的研究,与新潮的破裂(花园 III 或 IV ) 在 65 年上面变老的 285 个病人从 2001 年 1 月被包括到 2005 年 12 月。盒子随机被分配到 CRIF 组或 THA 组。有病理学的破裂(骨头肿瘤或新陈代谢的骨头疾病)的病人,大腿骨的头的外科手术前的 avascular 坏死,骨关节炎,风湿性关节炎,半身麻痹,长期的病床休息和影响新潮的功能的复杂并发症是 excluded.ResultsDuring 5年的后续,有的 CRIF 组更高显著地在新潮的关节复杂并发症评价,一般复杂并发症和操作比 THA 组织(38.3%对12.7%, P ;< ; 0.01 ;45.3% 对 21.7% , P < 0.01;33.6% 对 10.2% , P < 0.05 分别地) 。在在二个组之间的死亡没有差别。在与更高级的哈里斯 scores.ConclusionFor 有利地恢复的 THA 组的新潮的关节的手术后的功能在老病人,代替了大腿骨的颈的破裂 THA 能完成复杂并发症和操作的更低的率,以及新潮的联合功能的更好手术后的恢复与 CRIF 相比。 | Cao Liehu Wang Bin Li Ming Song Shaojun Weng Weizong Li Haihang Su Jiacan | 2014 | Chinese Journal of Traumatology2014，17，2： | 21 |
| 2 | MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro显示文摘MicroRNAs (miRNAs ) 是参予送信人 RNA 和蛋白质合成的空间与时间的规定的小非编码的 RNA。异常 miRNA 表示导致发展畸形和疾病。miR-135a 被认为是 oncogenic;然而,在 colorectal 癌症(CRC ) 的 miR-135a 的功能和机制大部分是未知的。因此,我们调查了 miR-135a 的功能和机制,特别与转移 suppressor 的它的关系 1 (MTSS1 ) 在 CRC 的基因。当它房间增长,移植,和侵略上的效果被 MTT 决定时, miR-135a 的表达式被即时聚合酶链反应分别地决定,没有并且与 matrigel。MTSS1 的表示被西方的污点分析检测。miR-135a 表示比在非肿瘤控制织物在人的 CRC 样品是更高的,这被发现。用 SW480 和 SW620 CRC 房间行,增加了增长响应 miR-135a 被观察。我们也证明分别地, miR-135a CRC 房间有或没有 Matrigel 经由 transwell 试金支持了活动性和侵略。相反, miR-135a 的抑制减少了他们的 proliferative 和侵略能力。MTSS1 被酶报告试金作为 miR-135a 的候选人目标基因识别。西方的污点分析证明 MTSS1 的表示被 miR-135a overexpression 调整并且击倒。同样,在 MTSS1 被小介入 RNA 击倒以后, miR-135a-mediated 房间活动性和侵略被减少。这些数据显示 miR-135a 支持 CRC 细胞的生长和侵略,至少部分,通过指向 MTSS1。 | Weiwei Zhou Xiayu Li Fen Liu Zhiming Xiao Miao He Shourong Shen Shaojun Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 19 |
| 3 | In situ experiments on width and evolution characteristics of excavation damaged zone in deeply buried tunnels显示文摘The seven long tunnels of Jinping II hydropower station are deeply buried.The width and evolution characteristics of excavation damaged zone(EDZ) are the key problem to the design of tunnels excavation and supports.In order to study this problem,several specific experimental tunnels with different overburden and geometric sizes were excavated at this site.Digital borehole camera,sliding micrometer,cross-hole acoustic wave equipment and acoustic emission apparatus were adopted.This paper introduced the comprehensive in situ experimental methods through pre-installed facilities and pre-drilled boreholes.Typical properties of the surrounding rock mass,including cracks,deformation,elastic wave and micro fractures,were measured during the whole process of the tunnel excavation.The width and characteristics of formation and evolution of tunnels EDZ were analyzed under different construction methods involving of TBM and drilling and blasting,the test tunnels were excavated by full-face or two benches.The relationships between EDZ and tunnel geometry sizes,overburden and excavation method were described as well.The results will not only contribute a great deal to the analysis of rock mass behavior in deeply buried rock mass,but also provide direct data for support design and rockburst prediction. | LI ShaoJun 1,FENG XiaTing 1,LI ZhanHai 3,CHEN BingRui 1,JIANG Quan 1,WU ShiYong 2,HU Bin 2 &XU JinSong 2 1 State Key Laboratory of Geomechanics and Geotechinical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 430071,China 2 Ertan Hydropower Development Company,Ltd.,Chengdu 610051,China 3 School of Resources and Civil Engineering,Northeastern University,Shenyang 110004,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 13 |
| 4 | Research advances in animal distant hybridization显示文摘Distant hybridization refers to crosses between two different species or higher-ranking taxa that enables interspecific genome transfer and leads to changes in phenotypes and genotypes of the resulting progeny.If progeny derived from distant hybridization are bisexual and fertile,they can form a hybrid lineage through self-mating,with major implications for evolutionary biology,genetics,and breeding.Here,we review and summarize the published literature,and present our results on fish distant hybridization.Relevant problems involving distant hybridization between orders,families,subfamilies,genera,and species of animals are introduced and discussed,with an additional focus on fish distant hybrid lineages,genetic variation,patterns,and applications.Our review serves as a useful reference for evolutionary biology research and animal genetic breeding. | ZHANG ZhuoHui CHEN Jie LI Ling TAO Min ZHANG Chun QIN QinBo XIAO Jun LIU Yun LIU ShaoJun | 2014 | Science China(Life Sciences)2014，57，9： | 11 |
| 5 | Studies on the evolution process of rockbursts in deep tunnels显示文摘This paper focuses on the evolution processes of different types of rockbursts occurring in deep tunnels. A series of laboratory tests and in-situ monitoring in deep tunnels excavated by tunnel boring machine (TBM) and drill-and-blast (D&B) method have been conducted to understand the mechanisms and processes of the evolution of different types of rockbursts, including strain rockburst, strain-structure slip rockburst, immediate rockburst and time-delayed rockburst. Three different risk assessment methods are proposed to evaluate the intensity and potential failure depth of rockbursts. These methods can be applied before excavation and the results can be updated according to the real-time information during excavation. Two micro-seismicity based real-time warning systems have been established for predicting various intensities of rockbursts, such as slight, moderate, intensive and extremely intensive rockbursts. Meanwhile, the probability and intensity of the rockburst are also given. The strategy for excavation and support design has been suggested for various intensities of rockbursts before excavation. The strategy for dynamic control of the rockburst evolution process is also proposed according to the monitoring results. The methodology has been successfully applied to rockburst risk reduction for deep tunnels at Jinping II hydropower project. The results have illustrated the applicability of the proposed methodology and techniques concerning rockbursts. | Xiating Feng Bingrui Chen Shaojun Li Chuanqing Zhang Yaxun Xiao Guangliang Feng Hui Zhou Shili Qiu Zhouneng Zhao Yang Yu Dongfang Chen Huajun Ming | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 11 |
| 6 | Passive seismic experiment and ScS wave splitting in the southwestern subbasin of South China Sea显示文摘The seismic experiment of 3D array of OBS in the southwestern sub-basin of the South China Sea(SCS) is briefly introduced in this paper.The data analysis of broadband OBS shows that totally 93 earthquakes with magnitude of Ms 6.0-6.9 and 10 earthquakes with magnitude above Ms 7.0 were recorded in high quality during this experiment,especially the catastrophic earthquake Ms 9.0 occurred in the east sea area of Japan on March 11,2011.The anisotropy parameters inversion of ScS wave of four events above Ms 7.0 indicates that the fast direction of shear wave is N58°E parallel to the ceased spreading ridge of the southwestern sub-basin of SCS(the slow direction is S35°E perpendicular to the spreading ridge),which means the spreading ridge is under compressing stress at present and the cessation of seafloor spreading is related to such stress field as well. | RUAN AiGuo LI JiaBiao LEE ChaoShing QIU XueLin PAN ShaoJun | 2012 | Chinese Science Bulletin2012，57，25： | 9 |
| 7 | Advances in BeiDou Navigation Satellite System(BDS)and satellite navigation augmentation technologies显示文摘Several noteworthy breakthroughs have been made with the BeiDou Navigation Satellite System(BDS)and other global navigation satellite systems as well as the associated augmentation systems,such as the commissioning of the BDS-3 preliminary system and the successful launch of the first BDS-3 GEO satellite which carries the satellite-based augmentation payload.Presently,BDS can provide basic services globally,and its augmentation system is also being tested.This paper gives an overview of BDS and satellite navigation augmentation technologies.This overview is divided into four parts,which include the system segment technologies,satellite segment technologies,propagation segment technologies,and user segment technologies.In each part,these technologies are described from the perspectives of preliminary information,research progress,and summary.Moreover,the significance and progress of the BeiDou Satellite-based Augmentation System(BDSBAS),low earth orbit augmentation,and the national BeiDou ground-based augmentation system are presented,along with the airborne-based augmentation system.Furthermore,the conclusions and discussions covering popular topics for research,frontiers in research and development,achievements,and suggestions are listed for future research. | Rui Li Shuaiyong Zheng Ershen Wang Jinping Chen Shaojun Feng Dun Wang Liwen Dai | 2020 | Satellite Navigation2020，1，1： | 9 |
| 8 | A high-quality genome sequence of alkaligrass provides insights into halophyte stress tolerance显示文摘Alkaligrass(Puccinellia tenuiflora) is a monocotyledonous halophytic forage grass widely distributed in Northern China. It belongs to the Gramineae family and shares a close phylogenetic relationship with the cereal crops, wheat and barley. Here, we present a high-quality chromosome-level genome sequence of alkaligrass assembled from Illumina, Pac Bio and 10× Genomics reads combined with genome-wide chromosome conformation capture(Hi-C) data. The ~1.50 Gb assembled alkaligrass genome encodes 38,387 protein-coding genes, and 54.9% of the assembly are transposable elements, with long terminal repeats being the most abundant. Comparative genomic analysis coupled with stress-treated transcriptome profiling uncovers a set of unique saline-and alkaline-responsive genes in alkaligrass. The high-quality genome assembly and the identified stress related genes in alkaligrass provide an important resource for evolutionary genomic studies in Gramineae and facilitate further understanding of molecular mechanisms underlying stress tolerance in monocotyledonous halophytes. The alkaligrass genome data is freely available at http://gffzz284c18d2de364501h59o5p0bxbk6u6nwc.ffgz.tsg.suse.edu.cn/data/alkaligrass.html. | Wenting Zhang Jie Liu Yongxue Zhang Jie Qiu Ying Li Baojiang Zheng Fenhong Hu Shaojun Dai Xuehui Huang | 2020 | Science China(Life Sciences)2020，63，9： | 8 |
| 9 | Estimation of the three-dimensional in situ stress field around a large deep underground cavern group near a valley显示文摘Understanding three-dimensional(3D)in situ stress field is of key importance for estimating the stability of large deep underground cavern groups near valleys.However,the complete 3D in situ stress fields around large deep underground cavern groups are difficult to determine based on in situ stress data from a limited number of measuring points due to the insufficient representativeness and unreliability of such measurements.In this study,an integrated approach for estimating the 3D in situ stress field around a large deep underground cavern group near a valley is developed based on incomplete in situ stress measurements and the stress-induced failures of tunnels excavated prior to the step excavation of the cavern group.This integrated approach is implemented via four interrelated and progressive basic steps,i.e.inference of the regional tectonic stress field direction,analyses of in situ stress characteristics and measurement reliability,regression-based in situ stress field analysis and reliability assessment,and modified in situ stress field analysis and reliability verification.The orientations and magnitudes of the 3D in situ stress field can be analyzed and obtained at a strategic level following these four basic steps.First,the tectonic stress field direction around the cavern group is deduced in accordance with the regional tectonic framework and verified using a regional crustal deformation velocity map.Second,the reliability of the in situ stress measurements is verified based on the locations and depths of stressinduced brittle failures in small tunnels(such as exploratory tunnels and pilot tunnels)within the excavation range of the cavern group.Third,considering the influences of the valley topography and major geological structures,the 3D in situ stress field is regressed using numerical simulation and multiple linear regression techniques based on the in situ stress measurements.Finally,the regressed in situ stress field is further modified and reverified based on the stress-induced brittle failures of small tunnels and the initial excavation of the cavern group.A case study of the Shuangjiangkou underground cavern group demonstrates that the proposed approach is reliable for estimating the 3D in situ stress fields of large deep underground cavern groups near valleys,thus contributing to the optimization of practical excavation and design of mitigating the instability of the surrounding rock masses during step excavations. | Dingping Xu Xiang Huang Quan Jiang Shaojun Li Hong Zheng Shili Qiu Huaisheng Xu Yonghong Li Zhiguo Li Xingdong Ma | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 6 |
| 10 | Establishment and application of distant hybridization technology in fish显示文摘Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated and obtained the main rules regarding inheritance and reproduction related to fish distant hybridization. Furthermore, we established one-step and multistep breeding technologies that were suitable for interspecific hybridization and intraspecific hybridization. Simultaneously, we used these two breeding technologies to produce a batch of diploid fish lineages and tetraploid fish lineages and improved fishes. In addition, we widely discuss the methods, technologies and results of hybridization breeding, referring to the domestic and foreign literature on fish hybridization. We hope that this paper will be beneficial for the research and application of fish hybrid breeding. | Shi Wang Chenchen Tang Min Tao Qinbo Qin Chun Zhang Kaikun Luo Rurong Zhao Jing Wang Li Ren Jun Xiao Fangzhou Hu Rong Zhou Wei Duan Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 11 | The chimeric genes in the hybrid lineage of Carassius auratus cuvieri(♀)×Carassius auratus red var.(♂)显示文摘Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids(WR-F1 and WR-F2) derived from the intraspecific hybridization of white crucian carp(Carassius auratus cuvieri, WCC, ♀) and red crucian carp(Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories(chimera, mutant, and biparental origin genes).The results revealed 19.04%, 4.17% chimeric genes and 6.90%, 5.05% mutations of orthologous genes in WR-F1 and WR-F2 respectively. Seventeen of twenty-three characterized genes(77%) were confirmed to be the chimeras at the genomic DNA level.The GO classification discovered that some chimeric and mutant genes were related to metabolic process, immune system and developmental process in WR-F1. Our results provide the new evidence that hybridization can combine the parental genomes,leading to changes in the genotype of the resultant hybrids. This is the first report on the formation of chimeric genes from fish intraspecific hybridization, which is potentially interesting from the context of both evolution and the genetic breeding of fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Xiujuan Xu Fangzhou Hu Jing Wang Jun Xiao Shi Wang Wuhui Li Min Tao Qinbo Qin Rurong Zhao Zhanzhou Yao Shaojun Liu | 2018 | Science China(Life Sciences)2018，61，9： | 6 |
| 12 | Co-doped IT-M0S2 nanosheets embedded in N,S-doped carbon nanobowls for high-rate and ultra-stable sodium-ion batteries显示文摘Despite various 2H-MoS/carbon hybrid nanostructures have been constructed and committed to improve the performance for sodium-ion batteries(SIBs),they still show the limited cycle stability due to the relatively large volumetric expansion during the charge-discharge process Herein,we report the construction of cobalt-doped few-layered 1T-MoS2 nanosheets embedded in N,S-doped carbon(CMS/NSC)nanobowls derived from metal-organic framework(MOF)precursor via a simple in situ sulfurization process.This unique hierarchical structure enables the uniformly dispersed Co-doped 1T-MoS2 nanosheets intimately couple with the highly conductive carbon nanobowls,thus efficiently preventing the aggregation.In particular,the Co-doping plays a crucial role in maintaining the integrity of structure for MoS2 during cycling tests,confirmed by first-principles calculations.Compared with pristine MoS2,the volume deformation of Co-doped MoS2 can be shrunk by a prominent value of 52%during cycling.Furthermore,the few-layered MoS2 nanosheets with 1T metalic phase endow higher conductivity,and thus can surpass its counterpart 2H semiconducting phase in battery performance.By virtue of the synergistic effect of stable structure,appropriate doping and high conductivity,the resulting CMS/NSC hybrid shows superior rate capability and cycle stability.The capacity of CMS/NSC can still be 235.9 mAh·g^-1 even at 25 A·g^-1,which is 51.3%of the capacity at 0.2 A·g^-1.Moreover,the capacity can still remain 218.6 mAh·g^-1 even over 8,240 cycles at 5 Ag·g^-1 with a low decay of 0.0044%per cycle,one of the best performances among the reportec MoS2-based anode materials for SIBs. | Peihao Li Yong Yang Sheng Gong Fan Lv Wei Wang Yiju Li Mingchuan Luo Yi Xing Qian Wang Shaojun Guo | 2019 | Nano Research2019，12，9： | 6 |
| 13 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 14 | Probabilistic analysis of tunnel displacements based on correlative recognition of rock mass parameters显示文摘Displacement is vital in the evaluations of tunnel excavation processes,as well as in determining the postexcavation stability of surrounding rock masses.The prediction of tunnel displacement is a complex problem because of the uncertainties of rock mass properties.Meanwhile,the variation and the correlation relationship of geotechnical material properties have been gradually recognized by researchers in recent years.In this paper,a novel probabilistic method is proposed to estimate the uncertainties of rock mass properties and tunnel displacement,which integrated multivariate distribution function and a relevance vector machine(RVM).The multivariate distribution function is used to establish the probability model of related random variables.RVM is coupled with the numerical simulation methods to construct the nonlinear relationship between tunnel displacements and rock mass parameters,which avoided a large number of numerical simulations.Also,the residual rock mass parameters are taken into account to reflect the brittleness of deeply buried rock mass.Then,based on the proposed method,the uncertainty of displacement in a deep tunnel of CJPL-II laboratory are analyzed and compared with the in-situ measurements.It is found that the predicted tunnel displacements by the RVM model closely match with the measured ones.The correlations of parameters have significant impacts on the uncertainty results.The uncertainty of tunnel displacement decreases while the reliability of the tunnel increases with the increases of the negative correlations among rock mass parameters.When compared to the deterministic method,the proposed approach is more rational and scientific,and also conformed to rock engineering practices. | Minzong Zheng Shaojun Li Hongbo Zhao Xiang Huang Shili Qiu | 2021 | Geoscience Frontiers2021，12，4： | 6 |
| 15 | Boudouard reaction driven by thermal plasma for efficient CO2 conversion and energy storage显示文摘Conversion of CO2 into CO using plasma processing powered by renewable energy is a promising method to convert intermittent sustainable electricity into storable chemical energy.Despite extensive research efforts worldwide,there is currently no process that achieves economically viable values for both CO2 conversion fraction and energy recovery efficiency simultaneously.Here we demonstrate that a process that utilizes the Boudouard reaction,CO^2++C→2 CO,driven by a thermal plasma allows both 95%CO2 conversion to CO and energy recovery efficiency of 70%,values far higher than seen so far.By comparing the conversion process with and without CO2 excitation by a plasma and by using optical emission spectroscopy we show that the improved performance is due to a novel mode of operation where CO2 is pyrolyzed into an active mixture of CO,O and O2 by an arc discharge which is then introduced into a fixed bed to interact with carbon material.In this way,the free oxygen in the mixture combusts with carbon to form CO,and residual plasma excited CO2 is reduced by carbon.In the overall process,the endothermic Boudouard reaction is partially replaced by an exothermic reaction,and the excess electric energy to produce CO2 plasma is reused in the carbon bed. | Zhikai Li Tao Yang Shaojun Yuan Yongxiang Yin Edwin J.Devid Qiang Huang Daniel Auerbach Aart W.Kleyn | 2020 | Journal of Energy Chemistry2020，29，6： | 5 |
| 16 | MCM-36 zeolites tailored with acidic ionic liquid to regulate adsorption properties of isobutane and 1-butene显示文摘Adsorption properties of an adsorbent or a catalyst towards adsorbates are crucial in the process of adsorption separation or catalytic reaction. Surface morphology and structure of adsorbents have a significant impact on the adsorption properties. In this study, a novel acidic ionic liquid, 1-butyl-3-(triethoxysilylpropyl)imidazolium hydrogen sulfate(i.e., [BTPIm][HSO_4]), was synthesized and subsequently grafted onto the MCM-36 zeolite for the regulation of its adsorption properties towards isobutane and 1-butene. The resultant [BTPIm][HSO_4]-immobilized MCM-36(i.e., MCM-36-IL) was characterized by FT-IR, XPS, XRD, SEM, TG/DTG and N_2 adsorption–desorption measurement. It was found that the specific surface area, micropore volume and mesopore volume of the MCM-36 support underwent a reduction upon the immobilization of ionic liquid,while the surface density of acid increased from 0.0014 to 0.0035 mmol·m^(-2). The adsorption capacity of isobutane and 1-butene on the MCM-36-IL was determined by a static volumetric method. Results demonstrated that the interaction between isobutane and MCM-36-IL was enhanced and the interaction between 1-butene and MCM-36-IL was reduced. As a result, a tunable adsorption ratio of isobutane/1-butene on MCM-36 was achieved.With the increase in surface density of acid and the tunable adsorption ratio of isobutane and 1-butene on the functionalized MCM-36, the acidic ionic liquid-immobilized zeolites are beneficial to obtain an improved reaction yield and a prolonged catalyst life in the reactions catalyzed by solid acid. | Hongxia Li Tao Zhang Shaojun Yuan Shengwei Tang | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 5 |
| 17 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 18 | Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2显示文摘In contrast to the extensive research about viral protein–host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection,few studies have examined interactions between host factors and viral RNAs(vRNAs).Here,we profiled vRNA–host protein interactomes for three RNA virus pathogens(SARS-CoV-2,Zika,and Ebola viruses)using ChIRP-MS.Comparative interactome analyses discovered both common and virus-specific host responses and vRNA-associated proteins that variously promote or restrict viral infection.In particular,SARS-CoV-2 binds and hijacks the host factor IGF2BP1 to stabilize vRNA and augment viral translation.Our interactome-informed drug repurposing efforts identified several FDA-approved drugs(e.g.,Cepharanthine)as broad-spectrum antivirals in cells and hACE2 transgenic mice.A co-treatment comprising Cepharanthine and Trifluoperazine was highly potent against the newly emerged SARS-CoV-2 B.1.351 variant.Thus,our study illustrates the scientific and medical discovery utility of adopting a comparative vRNA-host protein interactome perspective. | Shaojun Zhang Wenze Huang Lili Ren Xiaohui Ju Mingli Gong Jian Rao Lei Sun Pan Li Qiang Ding Jianwei Wang Qiangfeng Cliff Zhang | 2022 | Cell Research2022，32，1： | 5 |
| 19 | Responses of plant community to the linkages in plant-soil C:N:P stoichiometry during secondary succession of abandoned farmlands,China显示文摘Succession is one of the central themes of ecology;however,the relationship between aboveground plant communities and underground soils during secondary succession remains unclear.In this study,we investigated the composition of plant community,plant-soil C:N:P stoichiometry and their relationships during secondary succession after the abandonment of farmlands for 0,10,20,30,40 and 50 a in China,2016.Results showed that the composition of plant communities was most diverse in the farmlands after secondary succession for 20 and 50 a.Soil organic carbon and total nitrogen contents slightly decreased after secondary succession for 30 a,but both were significantly higher than those of control farmland(31.21%-139.10%and 24.24%-121.21%,respectively).Moreover,C:N ratios of soil and microbe greatly contributed to the changes in plant community composition during secondary succession of abandoned farmlands,explaining 35.70%of the total variation.Particularly,soil C:N ratio was significantly and positively related with the Shannon-Wiener index.This study provides the evidence of synchronous evolution between plant community and soil during secondary succession and C:N ratio is an important linkage between them. | LIU Weichao FU Shuyue YAN Shengji REN Chengjie WU Shaojun DENG Jian LI Boyong HAN Xinhui YANG Gaihe | 2020 | Journal of Arid Land2020，12，2： | 5 |
| 20 | In-situ observations of damage-fracture evolution in surrounding rock upon unloading in 2400-m-deep tunnels显示文摘The damage-fracture evolution of deep rock mass has obvious particularity,which is revealed in 2400-mdeep tunnels by field tests.The evolution of the excavation damaged zone depth is consistent with that of the fractured zone depth.The ratio of the excavation damaged zone depth to the excavation fractured zone depth is greater than 2.0 in a rock mass with both high strength and good integrity,but less than1.5 in a rock mass with lower strength or poor integrity.Zonal disintegration in a rock mass with high strength and fair integrity is more likely to occur when it contains more than two groups of primary fractures in damaged zones.Fractures develop outward in zonal disintegration but are totally different from the single-zone fracture,in which the fractures develop inward,and it is the starting position of the fractured zone when the excavation surface of the middle pilot is 7–9 m close to the pre-set borehole and it stops after the excavation surface of the baseplate is 11–14 m away.The most intense evolution occurs around 2–4 m from the pre-set borehole in the sidewall expansion stage.The research results provide a reference for the monitoring scheme and support design of CJPL-Ⅲin its future construction. | Haosen Guo Qiancheng Sun Guangliang Feng Shaojun Li Yaxun Xiao | 2023 | International Journal of Mining Science and Technology2023，33，4： | 5 |
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