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| 1 | Geochemistry and regional distribution of ophiolites and associated volcanics in Mianlüe suture, Qinling-Dabie Mountains显示文摘Systematic studies of the ophiolites and associated volcanics stretching more than 1500 km from the Derni-Nanping-Pipasi-Kangxian area in the west to the Qingshuihe area of the south Dabie Mountains in the east indicate the existence of a suture zone (the Mianl黣 suture) and a vanished paleo-ocean basin (the Mianl黣 paleo-ocean basin) in the region. From west to east, ophiolitic mlange associations distribute discontinuously along the suture. Rock assem-blages include ophiolite, island arc and oceanic island rock series. The Mianl黣 paleo-ocean basin experienced its major formation and expending episode during the Carboniferous-Permian period. The finding of the suture zone and the paleo-ocean basin is tectonically significant in timing the collision between the North China-Qinling and Yangtze blocks and determining the formation and evolution of the Qinling orogenic belt. | LAI Shaocong, ZHANG Guowei, DONG Yunpeng, PEI Xianzhi & CHEN Liang Key Laboratory of Continental Dynamics, Ministry of Education and Department of Geology, Northwest University, Xian 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 25 |
| 2 | U-Pb Zircon Age, Geochemical, and Sr-Nd-Pb Isotopic Constraints on the Age and Origin of Mafic Dykes from Eastern Shandong Province, Eastern China显示文摘U-Pb 锆石年龄, geochemical,和从东方山东省的 mafic 女同性恋的 Sr-Nd-Pb 同位素的数据,东方中国此处被报导。激光脱离诱导地联合了从调查 mafic 女同性恋的二件样品的 U-Pb 锆石分析产出一致年龄从 121.9 妈的血浆团 spectrometry (LA-ICP-MS )?????? 猠潨桳湯瑩捩吗? | LIU Shen HU Ruizhong FENG Caixia GAO Shan FENG Guangying LAI Shaocong QI Youqiang Ian M. COULSON YANG Yuhong YANG Chaogui TANG Liang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 7 |
| 3 | Inhibitory Effects of Propolis Water Extract on the Proliferation of Cervical Cancer Cells显示文摘[Objectives]To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment.[Methods]The effects of propolis on inflammation,and proliferation were analyzed based on the levels of DNA transcriptional regulation and mRNA and protein expression levels.[Results]Propolis water extract(PWE)could inhibit the cell proliferation and production of DNA damage in a dosedependent manner.Moreover,the propolis water extract could significantly downregulate the expression of iNOS-Luc,PTGS-2-Luc,and IL-8-Luc,and that it was related to the expression of the NF-κB family protein.After the induction of HeLa cells by propolis,the expression of the cell cycle inhibitor gene p21 was increased,while that of the cell proliferation gene Ki67 was decreased.[Conclusions]Propolis water extract could significantly inhibit the cell proliferation and production of DNA damage,suggesting propolis as a potential candidate for the development of adjunctive therapy against cervical cancer. | Wenbin XU Yimeng GAO Nailong LIANG Ling ZHANG Shuang XING Wensong HAO Shaocong LI | 2023 | Medicinal Plant2023，14，2： | 0 |
| 4 | Super-resolution microscopy based on parallel detection显示文摘Image scanning microscopy based on pixel reassignment can improve the confocal resolution limit without losing the image signal-to-noise ratio(SNR)greatly[C.J.R.Sheppard,'Super resolution in confocal imaging,'Optik 80(2)53-54(1988).C.B.Miller,E.Jorg,'Image scanning microscopy,'Phys.Reu.Lett.104(19)198101(2010).C.J.R.Sheppard,s.B.Mehta,R Heintzmann,'Superresolution by image scanning microscopy using pixel reassignment,'Opt.Lett.38(15)28892892(2013)].Here,we use a tailor-made optical fiber and 19 avalanche pho-todiodes(APDs)as parallel detectors to upgrade our existing confocal microscopy,termed as parallel-detection super resolution(PDSR)microscopy.In order to obtain the correct shift value,we use the normalized 2D cross correlation to calculate the shifting value of each image.We characterized our system performance by imaging fuorescence beads and applied this system to observing the 3D structure of biological specimen. | Zhimin Zhang Shaocong Liu Liang Xu Yubing Han Cuifang Kuang Yong Liu Xiang Hao Hongqin Yang Xu Liu | 2019 | Journal of Innovative Optical Health Sciences2019，，6： | 0 |
| 5 | 骨髓造血细胞来源的半乳糖苷凝集素导致细胞和系统胰岛素抵抗显示文摘肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Ga13)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Ga13水平明显增加。 | 李平平 Shuainan Liu Min Lu Gautum Bandyopadhyay Dayoung Oh Takeshi Imamura Andrew M.F.Johnson Dorothy Sears Zhufang Shen Bing Cui Lijuan Kong Shaocong Hou Xiao Liang Salvatore Iovino Steven M.Watkins Wei Ying Olivia Osborn Joshua Wollam Martin Brenner Jerrold M.Olefsky | 2017 | 科学新闻2017，19，4： | 0 |
| 6 | Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer显示文摘Programmed death ligand 1(PD-L1)immune checkpoint inhibitors are promising therapeutic agents for treating cancers but the response rate is<20%.Some chemotherapeutic drugs could also activate an anticancer immune response to kill cancer cells,apart from their direct cytotoxicity.Our study investigated the combination of chemotherapeutic drugs with PD-L1 antibody to enhance the response rate of PD-L1 blockade.Non-small cell lung cancer(NSCLC)cells were pre-treated with mitomycin C(MMC)and then co-cultured with peripheral blood mononuclear cells(PBMCs)to investigate the effect of the combination of MMC with PD-L1 antibody.The drug combination was also evaluated in vivo in Lewis lung cancer(LLC)cells-bearing C57BL/6 mice.MMC increased the expressions of PD-L1 and MHC-I in NSCLC cells in vitro and in vivo and enhanced the cytotoxic effect of lymphocytes on NSCLC in vitro.In LLC-bearing mouse model,the combination of MMC and PD-L1 antibody was found to be more effective in retarding tumor growth and prolonging overall survival than either single treatment alone,which was associated with increased lymphocyte infiltration and granzyme B release.Mechanistically,MMC activated the ERK pathway,which subsequently enhanced the binding of c-JUN to the PD-L1 promoter and recruited its co-factor STAT3 to increase PD-L1 expression.The upregulated ERK pathway was shown to activate p65 to increase the MHC-I expression.MMC was shown to enhance the efficacy of PD-L1 blockade in NSCLC cells.Further study is warranted to translate the findings to clinical application. | Min Luo Fang Wang Hong Zhang Kenneth KWTo Shaocong Wu Zhen Chen Shaobo Liang Liwu Fu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 7 | Mutually testing source-device-independent quantum random number generator显示文摘Quantum random numbers have an incomparable advantage over pseudo-random numbers since randomness originates from intrinsic property of quantum mechanics.The generation rate and the security of quantum random numbers are two significant indicators of a quantum random number generator(QRNG)for practical applications.Here we propose a mutually testing source-device-independent QRNG by simultaneously measuring a pair of conjugate quadratures from two separate parts of an untrusted continuous-variable quantum state.The amounts of randomness of the quadratures can be mutually estimated by each other via entropic uncertainty principle.Instead of randomly toggling between the conjugate quadratures of one state for collecting different types of data,two quadratures can generate check data and raw bits simultaneously and continuously in this mutually testing manner,which enhances the equivalent generation rate of private random bits to around 6 Gbit/s with a 7.5 mW laser beam.Moreover,the overall security is also improved by adjusting the conditional min-entropy in real time according to the continually monitored fluctuations of the local oscillator and the randomly measured electronic noise of homodyne detectors. | Jialin Cheng Jiliang Qin Shaocong Liang Jiatong Li Zhihui Yan Xiaojun Jia Kunchi Peng | 2022 | Photonics Research2022，10，3： | 0 |
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