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1篇 您的检索式：作者名="Kenneth KWTo"

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		题名	作者	年代	出处	被引量
	1	Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer显示文摘Programmed death ligand 1(PD-L1)immune checkpoint inhibitors are promising therapeutic agents for treating cancers but the response rate is<20%.Some chemotherapeutic drugs could also activate an anticancer immune response to kill cancer cells,apart from their direct cytotoxicity.Our study investigated the combination of chemotherapeutic drugs with PD-L1 antibody to enhance the response rate of PD-L1 blockade.Non-small cell lung cancer(NSCLC)cells were pre-treated with mitomycin C(MMC)and then co-cultured with peripheral blood mononuclear cells(PBMCs)to investigate the effect of the combination of MMC with PD-L1 antibody.The drug combination was also evaluated in vivo in Lewis lung cancer(LLC)cells-bearing C57BL/6 mice.MMC increased the expressions of PD-L1 and MHC-I in NSCLC cells in vitro and in vivo and enhanced the cytotoxic effect of lymphocytes on NSCLC in vitro.In LLC-bearing mouse model,the combination of MMC and PD-L1 antibody was found to be more effective in retarding tumor growth and prolonging overall survival than either single treatment alone,which was associated with increased lymphocyte infiltration and granzyme B release.Mechanistically,MMC activated the ERK pathway,which subsequently enhanced the binding of c-JUN to the PD-L1 promoter and recruited its co-factor STAT3 to increase PD-L1 expression.The upregulated ERK pathway was shown to activate p65 to increase the MHC-I expression.MMC was shown to enhance the efficacy of PD-L1 blockade in NSCLC cells.Further study is warranted to translate the findings to clinical application.	Min Luo Fang Wang Hong Zhang Kenneth KWTo Shaocong Wu Zhen Chen Shaobo Liang Liwu Fu	2020	Signal Transduction and Targeted Therapy2020，5，1：	0

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