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| 1 | Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells显示文摘瞄准:调查在增长,迁居,和老鼠骨髓的生肌的、脂肪形成的的区别上发信号的无翼相关的 MMTV 集成地点 3A (Wnt3a ) 的效果间充质的干细胞(rMSC ) 。方法:主要 MSC 被孤立并且从 Sprague-Dawley 老鼠有教养、由流动血细胞计数描绘。老鼠 L 房间是有 Wnt3a cDNA 的 transfected,并且调节了包含活跃 Wnt3a 蛋白质的媒介被准备。房间增长被房间计数和 5-bromodeoxyuridine 加入试金评估。rMSC 的迁居被使用 transwell 迁居和创伤愈合试金执行。在 rMSC 的生肌的、脂肪形成的的区别被轻显微镜学,免疫荧光,和 RT-PCR 在生肌的或脂肪形成的介绍以后在不同时间点检验。结果:发信号的 Wnt3a 导致了 beta-catenin 原子易位并且在 rMSC 激活 Wnt 小径。面对 Wnt3a, rMSC 比控制房间更快增殖了,使他们的区别潜在。而且,发信号的 Wnt3a 在在生肌的是有教养的以后导致了表示 rMSC 的 desmin 和肌浆球蛋白重链中的 2.62% 个和 3.76% 中等。生肌的区别基因,包括的 Pax7, MyoD, Myf5, Myf4,和肌浆蛋白在,在 Wnt3a 处理以后被激活。在另一方面, Wnt3a 在 rMSC 禁止了脂肪形成的区别通过下面 CCAAT/enhancer-binding 蛋白质高山的调整表示哈(C/EBPalpha ) 并且 peroxisome 激活 proliferator 的受体鲸鱼群妈(PPARgamma ) 。而且, Wnt3a 支持了 rMSC 的迁居能力。结论:结果显示在 rMSC 表明罐头 induce 生肌的区别的那 Wnt3a。发信号的 Wnt3a 也涉及增长的规定和 rMSC 的移植。这些结果能在人为基于房间的织物修理提供一个合理基础。 | Yan-chang SHANG Shu-hui WANG Fu XIONG Cui-ping ZHAO Fu-ning PENG Shan-wei FENG Mei-shan LI YongLI Cheng ZHANG | 2007 | Acta Pharmacologica Sinica2007，28，11： | 34 |
| 2 | Temperature effect and thermal impact in lithium-ion batteries: A review显示文摘Lithium-ion batteries, with high energy density(up to 705 Wh/L) and power density(up to 10,000 W/L), exhibit high capacity and great working performance. As rechargeable batteries, lithium-ion batteries serve as power sources in various application systems. Temperature, as a critical factor, significantly impacts on the performance of lithium-ion batteries and also limits the application of lithium-ion batteries. Moreover, different temperature conditions result in different adverse effects. Accurate measurement of temperature inside lithiumion batteries and understanding the temperature effects are important for the proper battery management. In this review, we discuss the effects of temperature to lithium-ion batteries at both low and high temperature ranges.The current approaches in monitoring the internal temperature of lithium-ion batteries via both contact and contactless processes are also discussed in the review. | Shuai Ma Modi Jiang Peng Tao Chengyi Song Jianbo Wu Jun Wang Tao Deng Wen Shang | 2018 | Progress in Natural Science:Materials International2018，28，6： | 27 |
| 3 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 4 | Inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma cells in vitro显示文摘AIM: To study the inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma (HCC) cells in vitro.METHODS: Antisense RNA of HAb18G/CD147 vector PCIasHAb18G was constructed by reversely inserting HAb18G/CD147 cDNA to eukaryotic expression vector PCI-neo. The HCC cell line HHCC was transfected by PCI-asHAb18G via cation liposome. Expression of HAb18G/CD147 of transfected cells selected by G418 (geneticin) was observed by immunohistochemical SP staining and FACS (fluorescence activated cell sorting). Gelatin zymography was used to determine the effect of PCI-asHAb18G on reducing secretions of MMP2 and MMP-9 of the transfected cells. Boyden chamber was employed to test the invasion of HCC cells in vitro.RESULTS: The construction of antisense RNA vector PCIasHAb18G was verified correct by partial nucleotide sequencing and restricted endonuclease digestion. The expression of HAb18G/CD147 in transfected HHCC was inhibited by PCI-asHAb18G. Secretions of MMP-2 and MMP9 of transfected HHCC were reduced and the invasion of transfected HHCC was inhibited compared to HHCC,respectively.CONCLUSION: Invasion of HCC cells can be inhibited by antisense RNA of HAb18G/CD147. HAb18G/CD147 may be used as a potential target of drugs for anti-invasion and metastasis of HCC. | Yu Li Peng Shang Ai-Rong Qian Li Wang Yong Yang Zhi-Nan Chen, Department of Cell Biology, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China | 2003 | World Journal of Gastroenterology2003，9，10： | 22 |
| 5 | Hawthorn Leaves Flavonoids Decreases Inflammation Related to Acute Myocardial Ischemia/Reperfusion in Anesthetized Dogs显示文摘调查山楂的效果和机制的目的在 anesthetized 狗把 flavonoids (HLF ) 留在尖锐心肌的 ischemia/reperfusion。尖锐局部缺血模型被绑扎准备的方法留给前面下降(男孩) 为 60 min 的动脉。合格 15 条雄的狗随机在每个组与 5 被划分成 3 个组:空白的控制(与正常对待盐 3 mL/kg ) 组,组和高剂量(10 mg/kg ) 组织的 HLF 低剂量(5 mg/kg ) ,与一一次通过一根大腿骨的静脉的注射在灌注前的 5 min。Epicardial 心电图被采用测量心肌的局部缺血的范围和度。同时,在梗塞(Inf ) 的嗜中性的渗入和心肌的织物的遥远的地点(RS ) 被 myeloperoxidase (军邮局) 测量活动试金。浆液 interleukin-1 (IL-1 ) 和肿瘤坏死因素(TNF-) 满足被放射性免疫测定确定。而且, G 联合蛋白质的受体 kinase 的表示 2 (GRK2 ) 并且在 Inf 和 RS 织物的原子因素 B (NF-B ) 被西方的弄污检测技术。结果局部缺血和灌注增加了 MPO 活动和 IL-1 和 TNF- 内容。HLF (10 和 5 mg/kg ) 能显著地减少心肌的局部缺血的度和范围;显著地禁止军邮局活动,和心肌的局部缺血 / 梗塞导致的 IL-1 和 TNF- 内容的增加。而且, HLF 增加了 GRK2 表示并且在 Inf 织物禁止了 NF-B 表示。结论 HLF 能改进尖锐心肌的局部缺血的状况并且在 anesthetized 狗禁止发炎,它可能由于它 GRK2 和 NF-B 表情上的增加的效果。 | Jian-hua Fu 付建华 (11250) Yong-qiu Zheng 郑咏秋 (11250) Peng Li 李 鹏 (11250) Xin-zhi Li 李欣志 (11250) Xiao-hong Shang 尚晓泓 (11250) Jian-xun Liu 刘建勋 (11250) | 2013 | Chinese Journal of Integrative Medicine2013，，8： | 20 |
| 6 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 7 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 8 | PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells显示文摘Phenethyl isothiocyanate(PEITC)is an isothiocyanate that largely exists in cruciferous vegetables and exhibits chemopreventive and chemotherapeutic potential against various cancers.However,it is little known about the molecular mechanisms of its antitumor action against osteosarcoma,which is the second highest cause of cancer-related death in children and adolescents.In this study,we investigated the effects of PEITC on K7M2murine osteosarcoma both in vitro and in vivo.We found that treatment with PEITC dose-dependently inhibited the viability of K7M2 murine osteosarcoma cells with an lCso value of 33.49μM at 24h.PEITC(1,15,30μM)dose-dependently inhibited the cell proliferation,caused G/M cell cycle arrest,depleted glutathione(GSH)generated reactive oxygen species(ROS),altered iron metabolism,and triggered multiple forms of cell death,namely ferroptosis apoptosis,and autophagy in K7M2 cells.We further revealed that PEITC treatment activated MAPK signaling pathway,and ROS generation was a major cause ofPEITC-induced cell death.In a syngeneic orthotopic osteosarcoma mouse model,administration of PEITC(30,60 mg/kg every day,ig,for 24 days)significantly inhibited the tumor growth,but higher dose of PEITC(90 mg/kg every day)compromised its ant-osteosarcoma effect.Histological examination showed that multiple cell death processes were initiated,iron metabolism was altered and MAPK signaling pathway was activated in the tumor tissues.In conclusion,we demonstrate that PEITC induces ferroptosis,autophagy,and apoptosis in K7M2 osteosarcoma cell by activating the ROS-elated MAPK signaling pathway.PEITC has promising anti-osteosarcoma activity.This study sheds light on,the redox signaling-based chemotherapeutics for cancers. | Huan-huan Lv Chen-xiao Zhen Jun-yu Liu Peng Shang | 2020 | Acta Pharmacologica Sinica2020，41，8： | 12 |
| 9 | Zonal extraction technology and numerical simulation analysis in open pit coal mine显示文摘In order to enhance coal recovery ratio of open pit coal mines,a new extraction method called zonal mining system for residual coal around the end-walls is presented.The mining system can improve economic benefits by exploiting haulage and ventilation roadways from the exposed position of coal seams by utilizing the existing transportation systems.Moreover,the main mining parameters have also been discussed.The outcome shows that the load on coal seam roof is about 0.307 MPa and the drop step of the coal seam roof about 20.3 m when the thickness of cover and average volume weight are about 120 m and 0.023 MN/m 3 respectively.With the increase of mining height and width,the coal recovery ratio can be improved.However,when recovery ratio is more than 0.85,the average stress on the coal pillar will increase tempestuously,so the recovery ratio should also be controlled to make the coal seam roof safe.Based on the numerical simulation results,it is concluded that the ratio of coal pillar width to height should be more than 1.0 to make sure the coal pillars are steady,and there are only minor displacements on the end-walls. | Chen Yanlong Cai Qingxiang Shang Tao Peng Hongge Zhou Wei Chen Shuzhao | 2012 | International Journal of Mining Science and Technology2012，22，4： | 11 |
| 10 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 11 | cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment显示文摘为模仿减少的严肃环境的一个新奇基于地面的模型广泛地在许多地里被使用了的抗磁的悬浮。在这研究,一个专辑设计了超导的磁铁,它能生产三个明显的严肃层次(0, 1,和 2 g ) ,也就是高的磁电机重力的环境(HMGE ) ,被用来模仿空间严肃环境。造骨细胞基因表示侧面上的 HMGE 的效果被 microarray 调查。对抗磁的悬浮环境(0 g ) 敏感的基因,严肃变化,和高磁场变化根据典型房间功能被排序。作为细胞内部的忍受负担的结构,细胞骨架在严肃感觉起一个重要作用。因此, 13 细胞骨架相关的基因根据 microarray 分析的结果被选择,并且这些基因的表情被发现被即时 PCR 在 HMGE 下面改变。基于 PCR 结果, WASF2 的表情(是蛋白质家庭,成员 2 ) , WIPF1 (WAS/WASL 交往蛋白质家庭,成员 1 ) , paxillin,和 talin 1 被西方的污点试金进一步识别。结果显示了那 WASF2, WIPF1 对改变的严肃层次,和 talin 更敏感 1 并且 paxillin 对磁场和严肃变化敏感。我们的调查结果证明 HMGE 能影响造骨细胞基因表示侧面和细胞骨架相关的基因表示。mechanosensitive 基因的鉴定可以提高我们的理解到 microgravity 导致的骨头损失的机制并且可以为阻止并且对待骨头损失或骨质疏松症提供一些潜在的目标。 | Airong Qian Shengmeng Di Xiang Gao Wei Zhang Zongcheng Tian Jingbao Li Lifang Hu Pengfei Yang Dachuan Yin Peng Shang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 8 |
| 12 | Advances in research of the mid-deep South China Sea circulation显示文摘The South China Sea(SCS)is a large marginal sea connecting the Indian and Pacific oceans.Under the factors of monsoons,strait transport,and varied bathymetry,the SCS presents a three-layer structure and strong diapycnal mixing which is far greater than that in the open ocean.Theoretical analysis and observations reveal that internal tides,internal solitary waves,and strong winds are the sources of the strong mixing in the northern SCS.A major consequence of the strong mixing is an active mid-deep circulation system.This system promotes exchange of water between the SCS and adjacent oceans,and also regulates the upper layer of wind-driven circulation,making the 3 dimensional SCS circulation clearly different from that in other tropical and subtropical marginal seas.The mass transport capacity of the mid-deep circulation has a substantial impact on marine sedimentation,the biogeochemical cycle,and other processes in the SCS.This paper summarizes the recent advances in middeep sea circulation dynamics of the SCS,and discusses the opportunities and challenges in this area. | Dongxiao WANG Qiang WANG Shuqun CAI Xiaodong SHANG Shiqiu PENG Yeqiang SHU Jingen XIAO Xiaohui XIE Zhiwei ZHANG Zhiqiang LIU Jian LAN Dake CHEN Huijie XUE Guihua WANG Jianping GAN Xinong XIE Rui ZHANG Hui CHEN Qingxuan YANG | 2019 | Science China Earth Sciences2019，62，12： | 8 |
| 13 | Effect of vasectomy via inguinal canal on spermatogenesis in rabbits显示文摘瞄准:决定是否输精管切除术离开 epididymal 尾巴(经由腹股沟的运河) 能在精子发生上在兔子减少早手术后的效果。方法:29 只正常雄的日本白兔子(4 6 个月) 受到单方结束结束(常规) 或无限制(juxta-epididymal 管的切割结束推迟 ens 没绑扎) 经由腹股沟的运河的输精管切除术。在操作,睾丸, epididymides 和管以后的十天和 3 个月一个 defer 统一体被移开并且 methacrylate 准备的嵌入树脂的节。睾丸, epididymis 和管的组织学推迟 ens 在轻显微镜下面被检验,并且生精的小管的体积和直径是用立体声学习的份量上逻辑方法。结果:任何一个输精管切除术的方法都没与相反地侧面的假冒操作方面,而是 juxta-epididymal 管比较在 vasectomized 方面上导致明显的损坏到精子发生推迟 vasectomized 方面上的 ens 高度被扩张并且包含了众多的精子在操作以后的 3 个月。结论:离开尾 epididymis 的输精管切除术没在兔子在精子发生上有重要早手术后的效果。 | Bin Peng Ya-Ping Wang Yi Shang Yang Guo Zheng-Wei Yang | 2008 | Asian Journal of Andrology2008，10，3： | 8 |
| 14 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 15 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 16 | Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features显示文摘现在的学习的目的是在人的间充质的干细胞(hMSCs ) 上调查反常严肃的效果。强壮的磁场和磁场坡度产生那能增加或从重力的力量减去的磁性的力量。在这研究,这被定义为 high-magneto-gravitational 环境(HMGE ) 。HMGE 提供三个明显的严肃层次,即 hypogravity (g) , hypergravity (2g ) 和有强壮的磁场(1g ) 的正常严肃条件。在 hMSCs 为 12 h 服从于 HMGE 以后,增长,形态学,结构和 apoptosis 被调查。结果证明 hMSCs 的增长在 g 状况下面被禁止。反常严肃导致了 apoptosis 房间的词法特征,例如房间收缩,膜 blebbing,原子染色质冷凝作用和 margination,减少的房间生存能力,和增加的 caspase-3/7 活动。在 g 状况下面的 apoptosis 的率直到 56.95% 。F 肌动朊压力纤维和微导管在反常严肃状况下面被破坏。在 g 条件下面,在 mRNA 和蛋白质层次的 p53 的表示分别地多于 9- 和 6 褶层是起来调整的。Pifithrin- , p53 的一个特定的禁止者,禁止了 apoptosis 并且阻止了反常严肃导致的细胞骨架的混乱。这些结果暗示 hMSCs 对反常严肃敏感并且展出了经典 apoptotic 特征,它可能与 p53 发信号被联系。 | Rui Meng Hui-yun Xu Sheng-meng Di Dong-yan Shi Ai-rong Qian Jin-fu Wang Peng Shang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 7 |
| 17 | Morphometric measurement of the patella on 3D model reconstructed from CT scan images for the southern Chinese population显示文摘 | Shang Peng Zhang Linan Hou Zengtao Bai Xueling Ye Xin Xu Zhaobin Huang Xu | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 18 | Application of the sodium hyaluronate-CNTF scaffolds in repairing adult rat spinal cord injury and facilitating neural network formation显示文摘The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI. A planar multielectrode dish system (MED64) was used to test the electrophysiological characteristics of the regenerated neural network in the lesioned area. Electrophysiology and behavior evaluation were used to evaluate functional recovery of paraplegic rat hindlimbs. The Dil tracing and immunofluorescence results suggest that the sodium hyaluronate-CNTF scaffold could activate the NSCs originating from the spinal cord ependymal, and facilitate their migration to the lesion area and differentiation into mature neurons, which were capable of forming synaptic contact and receiving glutamatergic excitatory synaptic input. The MED64 results suggest that functional synapsis could be established among regenerated neurons as well as between regenerated neurons and the host tissue, which has been evidenced to be glutamatergic excitatory synapsis. The electrophysiology and behavior evaluation results indicate that the paraplegic rats’ sensory and motor functions were recovered in some degree. Collectively, this study may shed light on paraplegia treatment in clinics. | Yabin Xie Wei Song Wen Zhao Yudan Gao Junkui Shang Peng Hao Zhaoyang Yang Hongmei Duan Xiaoguang Li | 2018 | Science China(Life Sciences)2018，61，5： | 6 |
| 19 | Atmospheric HULIS and its ability to mediate the reactive oxygen species (ROS): A review显示文摘Atmospheric humic-like substances(HULIS) are not only an unresolved mixture of macroorganic compounds but also powerful chelating agents in atmospheric particulate matters(PMs); impacting on both the properties of aerosol particles and health effects by generating reactive oxygen species(ROS). Currently, the interests of HULIS are intensively shifting to the investigations of HULIS-metal synergic effects and kinetics modeling studies, as well as the development of HULIS quantification, findings of possible HULIS sources and generation of ROS from HULIS. In light of HULIS studies, we comprehensively review the current knowledge of isolation and physicochemical characterization of HULIS from atmospheric samples as well as HULIS properties(hygroscopic, surface activity, and colloidal) and possible sources of HULIS.This review mainly highlights the generation of reactive oxygen species(ROS) from PMs, HULIS and transition metals, especially iron. This review also summarized the mechanism of ironorganic complexation and recent findings of OH formation from HULIS-metal complexes. This review will be helpful to carry out the modeling studies that concern with HULIS-transition metals and for further studies in the generation of ROS from HULIS-metal complexes. | Myat Sandar Win Zhengyang Tian Hui Zhao Kai Xiao Jiaxian Peng Yu Shang Minghong Wu Guangli Xiu Senlin Lu Shinich Yonemochi Qingyue Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 6 |
| 20 | Current state and suggestions for mechanical harvesting of corn in China显示文摘Corn(Zea mays L.) accounts for the largest shares of planting area and total yield of grain crops in China.Corn production has played a significant role in the country’s development of agriculture and national economy.Harvesting requires the largest amount of manual labor in the entire corn production process,accounting for about 50–60% of the total labor input. | XIE Rui-zhi MING Bo GAO Shang WANG Ke-ru HOU Peng LI Shao-kun | 2022 | Journal of Integrative Agriculture2022，21，3： | 5 |
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