|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B and liver transplantation: Molecular and clinical features that influence recurrence and outcome显示文摘Hepatitis B virus(HBV) continues to be a major cause of morbidity and mortality worldwide. It is estimated that about 350 million people throughout the world are chronically infected with HBV. Some of these people will develop hepatic cirrhosis with decompensation and/or hepatocellular carcinoma. For such patients, liver transplantation may be the only hope for cure or real improvement in quality and quantity of life. Formerly, due to rapidity of recurrence of HBV infection after liver transplantation, usually rapidly progressive, liver transplantation was considered to be contraindicated. This changed dramatically following the demonstration that hepatitis B immune globulin(HBIG), could prevent recurrent HBV infection. HBIG has been the standard of care for the past two decades or so. Recently, with the advent of highly active inhibitors of the ribose nucleic acid polymerase of HBV(entecavir, tenofovir), there has been growing evidence that HBIG needs to be given for shorter lengths of time; indeed, it may no longer be necessary at all. In this review, we describe genetic variants of HBV and past, present, and future prophylaxis of HBV infection during and after liver transplantation. We have reviewed the extant medical literature on the subject of infection with the HBV, placing particular emphasis upon the prevention and treatment of recurrent HBV during and after liver transplantation. For the review, we searched PubMed for all papers on the subject of 'hepatitis B virus AND liver transplantation'. We describe some of the more clinically relevant and important genetic variations in the HBV. We also describe current practices at our medical centers, provide a summary and analysis of comparative costs for alternative strategies for prevention of recurrent HBV, and pose important still unanswered questions that are in need of answers during the next decade or two. We conclude that it is now rational and cost-effective to decrease and, perhaps, cease altogether, the routine use of HBIG during and following liver transplantation for HBV infection. Here we propose an individualized prophylaxis regimen, based on an integrated approach and risk-assessment. | Tahereh Ghaziani Hossein Sendi Saeid Shahraz Philippe Zamor Herbert L Bonkovsky | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 2 | Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis 显示文摘 | Mokdad A A Lopez A D Shahraz S | 2014 | Bmc Medicine2014，12，1： | 1 |
| 3 | Liver,spleen,pancreas and kidney involvement by human fascioliasis:imaging findings显示文摘 | Zali MR Ghaziani T Shahraz S | 2004 | BMC Gastroentero2004，4，： | 1 |
| 4 | Building national estimates of the burden of road traffic injuries in developing countries from all available data sources:Iran显示文摘 | Bhalla K Naghavi M Shahraz S | | 0，，03： | 1 |
| 5 | Liver cirrhosis mortality in 187 countries between 1980 and 2010:a systematic analysis显示文摘 | Mokdad AA Lopez AD Shahraz S | 2014 | BMC Med2014，12，1： | 1 |
| 6 | A fuzzy sliding mode control approach for nonlinear chemical processes 显示文摘 | Shahraz A Bozorgmehry Boozarjomehry R | 2009 | Control Engineering Practice2009，17，5： | 1 |
| 7 | Liver cirrhosis mortality in 187 countries between 1980 and 2010:a systematic analysis显示文摘 | Mokdad AA Lopez AD Shahraz S | 2014 | BMC Med2014，12，1： | 1 |
| 8 | CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA显示文摘 | Sendi H Mehrab-Mohseni M Shahraz S | 2009 | J Clin Virol2009，46，3： | 1 |
| 9 | A fuzzy sliding model control approach for nonlinear chemical process显示文摘 | Shahraz A Boozarjomehry R Bozorgmehry | 2009 | Control Engineering Practice2009，17，5： | 1 |
| 10 | A fuzzy sliding model control approach for nonlinear chemical process 显示文摘 | Shahraz A Boozarjomehry R Bozorgmehry | 2009 | Control Engineering Practice2009，17，5： | 1 |
| 11 | CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA显示文摘 | Hossein Sendi Marjan Mehrab-Mohseni Saeid Shahraz Helene Norder Seyed-Moayed Alavian Babak Noorinayer Mohammad R. Zali Paul Pumpens Herbert L. Bonkovsky Lars O. Magnius | 2009 | Journal of Clinical Virology2009，，3： | 1 |
| 12 | Availability and quality of cause-of-death data for estimating the global burden of injuries显示文摘 | Bhalla K Harrison JE Shahraz S | | 0，，11： | 1 |
| 13 | Wetting on physically patterned solid surfaces:the relevance of molecular dynamics simulations to macroscopic systems显示文摘 | SHAHRAZ A BORHAN A FICHTHORN K A | 2013 | Langmuir52013，29，11： | 1 |
| 14 | A fuzzy sliding mode eontrol approach for nonlinear chemical processes 显示文摘 | SHAHRAZ A BOOZARJOMEHRY R B | 2009 | Control Engineering Practice2009，17，5： | 1 |
| 15 | A fuzzy sliding mode control approach for nonlinear chemical processes 显示文摘 | Shahraz R Bozorgmehry Boozarjomehry | 2009 | Control Engineering Practice2009，17，： | 1 |
| 16 | A fuzzy sliding mode control approach for nonlinear chemical processes显示文摘 | Shahraz A Bozorgmehry B R | 2009 | Control Engineering Practice2009，17，5： | 1 |
| 17 | Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental factors.Ecological studies previously suggested a link between climatological factors and COVID-19 fatality rates.However,individual-level impact of these factors has not been thoroughly evaluated yet.AIM To study the association of climatological factors related to patient location with unfavorable outcomes in patients.METHODS In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital stay.Adjusting for baseline parameters and admission date,multivariable regression modeling was utilized.Generalized estimating equations were used to fit the models.RESULTS Twenty-two thousand one hundred eight patients from over 20 countries were evaluated.The median age was 62(interquartile range:49-74)years,and 54%of the included patients were males.The median age increased with increasing latitude as well as the frequency of comorbidities.Contrarily,the percentage of comorbidities was lower in elevated altitudes.Mortality within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 d.Despite the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality within 28 d of hospital admission(aOR=0.96(0.62,1.47),1.04(0.92,1.19),0.49(0.22,0.90),and 0.51(0.27,0.98),for the altitude points of 75 MASL,125 MASL,400 MASL,and 600 MASL,in comparison to the reference altitude of 148 m.a.s.l,respectively.P=0.001).We detected an association between latitude and 28-day mortality as well as hospital-free days in this worldwide study.When the baseline features were taken into account,however,this did not stay significant.CONCLUSION Our findings suggest that differences observed in previous epidemiological studies may be due to ecological fallacy rather than implying a causal relationship at the patient level. | Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie Syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group | 2022 | World Journal of Critical Care Medicine2022，11，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员