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| 1 | Analyses of oligodontia phenotypes and genetic etiologies显示文摘Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis.Many genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical presentation.The purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia patients.An online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic records.Additionally,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence analyses.We identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRP6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with oligodontia.For each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were calculated.Genotype–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations. | Mengqi Zhou Hong Zhang Heather Camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-Wook Kim Hera Kim-Berman Ninna M.R.Yuson Paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu James P.Simmer Jan C-C.Hu | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 2 | Elderly at Greater Risk for Root Caries: A Look at the Multifactorial Risks with Emphasis on Genetics Susceptibility显示文摘 | Daniel Gati Alexandre R. Vieira Figen Seymen | 2011 | International Journal of Dentistry2011，，： | 1 |
| 3 | Effect of Ringer-Lactate and isotonic saline so-lutions on mucociliary clearance of tracheal epithelium:an experimental study in rats显示文摘 | Unal M Seymen HO | 2002 | J Laryngol Otol2002，116，7： | 1 |
| 4 | Effects of beta-adrebergic receptor blockers on cardiac function:a comparative study in male versus femalerats显示文摘 | Tuncay E Seymen AA Sam P | 2009 | Can J Physiol Pharmacol2009，87，4： | 1 |
| 5 | Fused teeth: A re- view of the treatment options 显示文摘 | Tuna EB Yildirim M Seymen F | 2009 | J Dent Child ( Chic)2009，76，2： | 1 |
| 6 | MMP20 hemopexin domain mu- tation in amelogenesis imperfecta显示文摘 | Lee SK Seymen F Kang HY | 2010 | Dent Res2010，89，1： | 1 |
| 7 | Novel WDR72 mutation and cyto- plasmic localization显示文摘 | Lee SK Seymen F Lee KE | 2010 | Dent Res2010，89，12： | 1 |
| 8 | RUNX2 mutations in cleidocranial dysplasia显示文摘 | Lee KE Seymen F Ko J | 2013 | Genet Mol Res2013，12，4： | 1 |
| 9 | Candidate gene strategy reveals ENAM mutations显示文摘 | Kang HY Seymen F Lee SK | 2009 | J Dent Res2009，88，3： | 1 |
| 10 | ENAM mutations in autosomal-dominant amelogenesis imperfecta显示文摘 | Kim JW Seymen F Lin BP | 2005 | J Dent Res2005，84，3： | 1 |
| 11 | ENAM mutations with incomplete penetranee 显示文摘 | Seymen F Lee KE Koruyucu M | 2014 | J Dent Res2014，93，10： | 1 |
| 12 | Antioxidants but not doxycycline treatments restore depressed beta-adrenergic responses of the heart in diabetic rats显示文摘 | Bilginoglu A Seymen A Tuncay E | 2009 | Cardiovasc Toxicol2009，9，1： | 1 |
| 13 | Flavone C-glycosides from Scleranthus uncinatus 显示文摘 | Yayli N Seymen H Baltaci C | 2001 | Phytochemistry2001，58，4： | 1 |
| 14 | Novel WDR72 Muta- tion and Cytoplasmic Localization显示文摘 | Lee S K Seymen F Lee K E | 2010 | Journal of Dental Research2010，89，12： | 1 |
| 15 | Prosthetic repair of acutely incarcerated groin hernias: a prospective clinical observational cohort study显示文摘 | Koray Atila Sanem Guler Abdullah Inal Selman Sokmen Sedat Karademir Seymen Bora | 2010 | Langenbeck’s Archives of Surgery2010，，5： | 1 |
| 16 | Effects of iluprost on visual evoked potentials and brain tissue oxidative stress after bilateral common carotid artery occlusion 显示文摘 | Aytac E Seymen HO Uzun H | 2006 | Prostagl Leukot Essent Fatty Acids2006，74，6： | 1 |
| 17 | ENAM mutation autosomaldominane amelogenesis imperfecta显示文摘 | Kim JW Seymen F Lin BP | 2005 | J Dent Res2005，84，3： | 1 |
| 18 | Effects of beta-adren- ergic receptor on cardiac function:a comparative study in male versus female 显示文摘 | Tyncay E Seymen AA Sam P | 2009 | Can J Physical Pharmacology2009，87，4： | 1 |
| 19 | RUNX2 mutations in cleidocranial dysplasia显示文摘 | Lee KE Seymen F Ko J' | 2013 | Genet Mol Res2013，12，4： | 1 |
| 20 | Effects of beta-adrebergic receptor blockers on cardiac function:a comparative study in male versus femalerats显示文摘 | Tuncay E Seymen AA Sam P | 2009 | Can J Physiol Pharmacol2009，87，： | 1 |
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