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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Modal Testing, Finite Element Model Updating and Dynamic Analysis of an Arch Type Steel Foot- bridge显示文摘 | BAYRAKTAR A ALTUNISIK A C SEVIM B | 2009 | Journal of Performance of Constructed Fa- cilities2009，23，2： | 1 |
| 3 | Finite Element Model Updating of Komurhan Highway Bridge Based on Experimental Measure- ments显示文摘 | BAYRAKTAR A ALTUNISIK A C SEVIM B | 2010 | Journal of Smart Structures and Systems2010，6，4： | 1 |
| 4 | Effect of Abdominal Obesity on Insulin Resistance and the Components of the Metabolic Syndrome: Evidence Supporting Obesity as the Central Feature显示文摘 | ?avlan Türkoglu MD Belgin Süsleyici Duman PhD Demet Günay PhD Penbe ?agatay PhD Remzi ?zcan MD A Sevim Büyükdevrim MD | 2003 | Obesity Surgery2003，，5： | 1 |
| 5 | Side Effects Associated with the Treatment of Muhidrug-Resistant Tuberculosis 显示文摘 | Torun T Gungor G Ozmen I Bolukbasi Y Maden E Bicakci B Atac G Sevim T Tahaoglu K | 2005 | Int J Tubere Lung Dis2005，9，12： | 1 |
| 6 | Practical development of an Eclipse-based software fault prediction tool using Naive Bayes algorithm显示文摘 | Catal C Sevim U Diri B | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 7 | Fabrication and characteriza- tion of anhydrous polymer electrolyte membranes based on sulfonat- ed poly(vinyl alcohol) and benzimidazole显示文摘 | Mehtap SB Sevim UC Ayhan B | 2012 | Polymer Science Series A2012，54，3： | 1 |
| 8 | Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children显示文摘 | Agirbasli M Tanrikulu A Acar Sevim B | 2015 | J Clin Lipidol2015，9，2： | 1 |
| 9 | Effect of fracture toughness on abrasive wear resistance of steels显示文摘 | Sevim I Eryurek I B | 2006 | Materials&design2006，27，10： | 1 |
| 10 | Effect of fracture toughness on ab- rasive wear resistance of steels 显示文摘 | Sevim I Eryurek I B | 2005 | Materials and De- sign2005，27，10： | 1 |
| 11 | Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis显示文摘 | Hachmann A B Sevim E Gaballa A | 2011 | Antimicrob Agents Chemother2011，55，9： | 1 |
| 12 | Corneal endothelial cell loss inpost-penetrating keratoplasty,patients after cataract surgery:phacoemulsification versus planned extracapsular cataract extrac tion显示文摘 | Acar B T Buttanri I B Sevim M S | 2011 | Journal of Cataract and Refractive Surgery2011，37，29： | 1 |
| 13 | A study on recovery of gold from decopperized anode slime显示文摘 | DONMEZ B SEVIM F COLAK S | 2001 | Chemical Engineering & Technology2001，24，： | 1 |
| 14 | Effect of abrasive particle size on wear resistance in steels 显示文摘 | Sevim I Eryurek I B | 2006 | Materials and Design2006，27，3： | 1 |
| 15 | A study on recovery of gold from decopperized anode slime 显示文摘 | Donmez B Sevim F Colak S | 2001 | Chemical Engineering & Technology2001，24，： | 1 |
| 16 | A study on recovery of goldfrom decopperized anode slime显示文摘 | Donmez B Sevim F Colak S | 2001 | Chemical Engineering &Techology2001，24，1： | 1 |
| 17 | Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey显示文摘 | Ozgumus O B Sandalli C Sevim A | 2009 | J Microbiol2009，47，1： | 1 |
| 18 | A study on recovery of gold from decopperized anode slime 显示文摘 | Donmez B Sevim F Colak S | 2001 | Chemical Engineer-ing & Technology2001，24，： | 1 |
| 19 | Study on recovery of gold from decopperized anode slime显示文摘 | DONMEZ B SEVIM F COLAK S | 2001 | Chemical Engineering & Technology2001，24，1： | 1 |
| 20 | Genetic variations of the apolipoprotein B gene in Turkish patients with coronary artery disease显示文摘 | Belgin S. Duman ? avlan Tü rko&gbreve lu Belhhan Akpinar Mustafa Gü den Anastassia Vertii Penbe ? a&gbreve atay Demet Gü nay A. Sevim Bü yü kdevrim | 2005 | Annals of Human Biology2005，，5： | 1 |
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