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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Side Effects Associated with the Treatment of Muhidrug-Resistant Tuberculosis 显示文摘 | Torun T Gungor G Ozmen I Bolukbasi Y Maden E Bicakci B Atac G Sevim T Tahaoglu K | 2005 | Int J Tubere Lung Dis2005，9，12： | 1 |
| 3 | Lubricant basestocks from vegetable oils显示文摘 | Sevim Z E Svajus A | 2000 | Ind Crop Prod2000，，11： | 1 |
| 4 | Determination of the bacterial flora as a microbial control agent of Toxoptera aurantii ( Homoptera: Aphididae) 显示文摘 | Sevim E Celebi O Sevim A | 2012 | Biologia2012，67，2： | 1 |
| 5 | Soybean oil-based lubricants : a search for synergistic antioxidants 显示文摘 | Brajendra K S Joseph M P Sevim Z E | 2007 | Energy Fuels2007，21，4： | 1 |
| 6 | Treatment adherence of 717 patients with tuberculosis in a social security system hospital in Istanbul,Turkey显示文摘 | Sevim T Aksoy E Atac G | 2002 | Int J Tuberc Lung Dis2002，6，1： | 1 |
| 7 | Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis显示文摘 | Hachmann A B Sevim E Gaballa A | 2011 | Antimicrob Agents Chemother2011，55，9： | 1 |
| 8 | The effect of two different methods of pe- ripheralvenous blood collection on pain reduction in neonates 显示文摘 | Emine E Sevim S | 2007 | Agri2007，19，2： | 1 |
| 9 | Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2, 5-disubstituted-l, 3, 4- oxadiazolines 显示文摘 | Sevim R Nehir G Habibe E | 2002 | Il Farmaco2002，57，： | 1 |
| 10 | Synthesis of carbonated fatty methyl ester using surpercritical carbon dioxid显示文摘 | Kenneth M D Sevim Z E | 2005 | Journal ofAgricultural and Food Chemistry2005，53，： | 1 |
| 11 | Exercise-induced apoptosis of rat skeletal muscle and the effect of meloxicam显示文摘 | SULE A SEVIM E AYSEN S | 2003 | Rheumat Intl2003，21，4： | 1 |
| 12 | Soybean oil-basedlubricants : a search for synergistic antioxidants 显示文摘 | Brajendra K S Joseph M P Sevim Z E | 2007 | Energy &Fuels2007，21，： | 1 |
| 13 | Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines显示文摘 | Sevim R Nehir G Habibe E | 2002 | Il Farmaco2002，57，： | 1 |
| 14 | Treatment adhe-rence of 717 pa- tients with tuberculosis in a social security system hospital in Istanhul,Turkey显示文摘 | Sevim T Aksoy E Atac G | 2002 | Int J Tuberc Lung Dis2002，6，1： | 1 |
| 15 | Exercise-induced apoptosis of rats keletal muscle and the effect of meloxicam显示文摘 | SULE A SEVIM E AYSEN S | 2003 | Rheumatology Int2003，21，4： | 1 |
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