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| 1 | Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection显示文摘AIM:To evaluate the effects of tenofovir disoproxil fumarate(TDF)use during late pregnancy to reduce hepatitis B virus(HBV)transmission in highly viremic mothers.METHODS:This retrospective study included 45 pregnant patients with hepatitis B e antigen(+)chronic hepatitis B and HBV DNA levels>107copies/mL who received TDF 300 mg/d from week 18 to 27 of gestation(n=21).Untreated pregnant patients served as controls(n =24).All infants received 200 IU of hepatitis B immune globulin(HBIG)within 24 h postpartum and 20μg of recombinant HBV vaccine at 4,8,and 24 wk.Perinatal transmission rate was determined by hepatitis B surface antigen and HBV DNA results in infants at week 28.RESULTS:At week 28,none of the infants of TDFtreated mothers had immunoprophylaxis failure,whereas2(8.3%)of the infants of control mothers had immunoprophylaxis failure(P=0.022).There were no differences between the groups in terms of adverse events in mothers or congenital deformities,gestational age,height,or weight in infants.At postpartum week 28,significantly more TDF-treated mothers had levels of HBV DNA<250 copies/mL and normalized alanine aminotransferase compared with controls(62%vs none,P<0.001;82%vs 61%,P=0.012,respectively).CONCLUSION:TDF therapy during the second or third trimester reduced perinatal transmission rates of HBV and no adverse events were observed in mothers or infants. | Mustafa Kemal Celen Duygu Mert Müzeyyen Ay Tuba Dal Safak Kaya Necmettin Yildirim Serda Gulsun Tunga Barcin Sevgi Kalkanli Mehmet Sinan Dal Celal Ayaz | 2013 | World Journal of Gastroenterology2013，19，48： | 26 |
| 2 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 3 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 4 | Topical antimicrobialsfor burn infections-an update 显示文摘 | Sevgi M Toklu A Vecchio D | 2013 | Recent Pat AntiinfectDrug Discov2013，8，3： | 1 |
| 5 | Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoeh - Sch6nlein purpura显示文摘 | Yilmaz T Sevgi M Afig B | 2012 | Rheumatology International2012，32，4： | 1 |
| 6 | An experiment on the con-sistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | EuropeanJournal of Operational Research2006，171，1： | 1 |
| 7 | An integrated maritime sur- veillance system based on high-frequency surface-wave radars op- erational status and system performance显示文摘 | Ponsford A M Sevgi L Chan H C | 2001 | Antennas and Propagation Magazine2001，43，5： | 1 |
| 8 | An experiment on the consistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 9 | An experiment on the consistency of aggregated comparison matrices in AHP 显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 10 | Paradoxical air microembolism induces cerebral bioelectrical abnormalities and occasionally headache in patent foramen ovale patients with migraine 显示文摘 | Sevgi EB Erdener SE Demirci M | 2012 | J Am Heart Assoc2012，1，00： | 1 |
| 11 | Radar cross section (RCS) model- ing and simulation: Part II-A novel FDTD-based RCS prediction virtual tool 显示文摘 | Caklr G Caklr M Sevgi L | 2008 | IEEE Antennas and Propagation Magazine2008，50，2： | 1 |
| 12 | Therapeutic drug monitoring in Turkey:experiences form Istanbul显示文摘 | OZEK M SEVGI S | 2000 | Ther Drug Monit2000，22，5： | 1 |
| 13 | A green vehicle routing problem显示文摘 | Sevgi E Elise M H | 2012 | Transportation Research: Part E2012，48，1： | 1 |
| 14 | Modeling with fractional difference equations显示文摘 | FERHAN M ATICI SEVGI Seng/il | 2010 | J Math Anal Appl2010，369，1： | 1 |
| 15 | An experiment on the consistency of aggregated compareson matrices in AHP显示文摘 | RHONDA A H SEVGI E JOSHUA M | | 0，，01： | 1 |
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