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| 1 | Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers显示文摘Insulin-like growth factor-bindin g proteins (IGFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IGF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IGFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IGF (IGF-dependent effects) and sometimes not (IGF-independent effects). The functional role of IGFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IGFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IGFBP5 in different types of cancers. | Gökçe Güllü Sevgi Karabulut Mustafa Akkiprik | 2012 | Chinese Journal of Cancer2012，31，6： | 8 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | e-Government adoption model based on the theory of planned behavior:Empirical val- idation显示文摘 | Sevgi O Irfan E K | 2011 | Government Information Quarterly2011，16，8： | 1 |
| 4 | An experiment on the con-sistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | EuropeanJournal of Operational Research2006，171，1： | 1 |
| 5 | Bilateral multiple tumor like endobronchial tuberculosis, iagnosed with bronchoscopic examina- tion显示文摘 | Saygideger Y Oktay B Sevgi E | 2011 | Tuberk Toraks2011，59，3： | 1 |
| 6 | An experiment on the consistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 7 | An experiment on the consistency of aggregated comparison matrices in AHP 显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 8 | A green vehicle routing problem显示文摘 | Sevgi E Elise M H | 2012 | Transportation Research: Part E2012，48，1： | 1 |
| 9 | C-Jun N-terminal kina- ses (JNKs) and the cytoskeleton-functions beyond neurode- generation 显示文摘 | Mathias G Sevgie E Thomas H | 2004 | International Journal of Developmental Neu- roscience2004，22，7： | 1 |
| 10 | Comparison of health-related quality of life and exercise capacity according to stages in patients with nonsmall cell lung cancer显示文摘 | Elvan Y Sevgi O Hasan E | 2013 | Tuberk Toraks2013，61，2： | 1 |
| 11 | An experiment on the consistency of aggregated compareson matrices in AHP显示文摘 | RHONDA A H SEVGI E JOSHUA M | | 0，，01： | 1 |
| 12 | Bilateral multiple tumor-like endobronchial tuberculosis, diagnosed with bronchoscopic examination 显示文摘 | Saygideger Y Oktay B Sevgi E | 2011 | Ttiberktiloz ve Toraks Dergisi2011，59，： | 1 |
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