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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | The mechanism of enzyme in the collagen extracting 显示文摘 | MILLER E J RHODES R K | 1982 | Methods in enzymology1982，82，： | 2 |
| 3 | Animal and temporal effects on ovarian follicular dynamics in Brahman heifers显示文摘 | Rhodes J M de Ath G Entwisfle K W | 1995 | Anita Reprod Sci1995，38，： | 1 |
| 4 | Predicion of incompressible flow in a labyrinth seal 显示文摘 | RHODE D L DEMKO J A TRAEGNER U K | 1986 | ASME Journal of Fluids Engineering1986，108，： | 1 |
| 5 | Worldwide Refining:Distillation Capacity Excceeds 76 Mb/d,Hydrotreating Surges显示文摘 | Rhodes A K | 1996 | Oil Gas J1996，94，52： | 1 |
| 6 | Analysis of the major flavonol glycoside present in four varieties of onion and changes in composition resulting from autolysis 显示文摘 | Price K R Rhodes M J C | 1997 | J Sci Food Ag- rlc1997，74，： | 1 |
| 7 | Study of Geldart's Group A behaviour using the discrete element method simulation 显示文摘 | Pandit J K Wang X S Rhodes M J | 2005 | Powder Technology2005，160，1： | 1 |
| 8 | The impact of U-238 resonance elastic scattering approxima- tions on thermal reactor Doppler reactivity显示文摘 | LEE D SMITH K RHODES J | 2009 | Annals of Nuclear Energy2009，36，3： | 1 |
| 9 | Erkl positively regulatesosteoclast differentiation and bone resorptive activity 显示文摘 | He Y Staser K Rhodes SD etal | 2011 | PLoS One2011，6，24： | 1 |
| 10 | Genetic structure of camouflage grouper, Epinephelus polyphekadion(Pisces:Serranidae), in the western central Pacific显示文摘 | Rhodes K L Lewis R I Chapman RW Sadovy Y | 2003 | Marine Biology2003，142，4： | 1 |
| 11 | Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor显示文摘 | West B E Parker G E Savage J J Kiratipranon P Toomey K S Beach L R Colvin S C Sloop KW Rhodes S J | | 0，，： | 1 |
| 12 | Septic arthritis in children显示文摘 | MORREY B F BIANCO A J Jr RHODES K H | 1975 | Orthop Clin Noah Am1975，6，4： | 1 |
| 13 | gammadeltaT ceil-media- ted regulation of chemokine producing macrophages during Liste- ria monocytagenes infection-induced inflammation 显示文摘 | Tramonti D Rhodes K Martin N | 2008 | J Pathol2008，216，2： | 1 |
| 14 | Collecting behavioural data using the world wide web:considerations for researchers显示文摘 | Rhodes S Bowie D Hergenrather K | 2003 | Journal of Epidemiology and Community Health2003，57，： | 1 |
| 15 | Albumin micrespheres for study of the reticuloendothial system显示文摘 | Scheffel U Rhodes B A Natarazan T K | 1973 | J Nucl Med1973，13，： | 1 |
| 16 | Examining medication errors in a tertiary hospital显示文摘 | Maricle K Whitebead L Rhodes M | 2007 | J Nurs Care Qual2007，22，1： | 1 |
| 17 | The injury response of oligodendrocyte precursor cells is induced by platelets,macrophages and inflammation-associated cytokines显示文摘 | Rhodes K E Raivich G Fawcett J W | 2006 | Neuroscience2006，140，： | 1 |
| 18 | The surface chemistry of zinc dialkydithiophophate, an antiwear additive, on oxidized iron and steel foils显示文摘 | Rhodes K L Stair P C | 1988 | Journal Vacuum Science Technology1988，6，： | 1 |
| 19 | Characterization of the pharmacokinetics of human recombinant erythropoietin in blood and brain when administered immediately after lateral fluid percussion brain injury and its pharmacodynamic effects on IL-1beta and MIP-2 in rats显示文摘 | Lieutaud T Andrews P J Rhodes J K | 2008 | J Neurotrauma2008，25，10： | 1 |
| 20 | Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarc-tion and improves neurological outcome in a rat model of focal cere-bral ischemia显示文摘 | Wang Y Zhang Z G Rhodes K | 2007 | Br J Pharmacol2007，151，8： | 1 |
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