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| 1 | Early radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy显示文摘AIM To report early imaging assessment of ablated area post electrochemotherapy(ECT) in patients with locally advanced pancreatic cancer(LAPC). METHODS ECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase Ⅰ/Ⅱ study. Before and after ECT, 18 patients underwent computed tomography(CT) scan, 11 patients underwent morphological and functional magnetic resonance(MR) scan(dynamic contrast enhanced-MRI) calculating wash-in slope(WIS) and wash-out slope(WOS); diffusion weighted imaging calculating pseudo-diffusivity(Dp), perfusion fraction(fp) and tissue diffusivity(Dt); 10 patients underwentpositron emission tomography(PET). Response evaluation criteria in solid tumour(RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors(PERCIST) on PET and functional parameters on MR were used to evaluate treatment response.RESULTS For each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18(100.0%) patients. According PERCIST criteria 6/10(60.0%) patients showed a partial response, 3/10(30.0%) stable disease and 1/10(10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11(81.8%) patients exhibited a partial response and 2/11(18.2%) stable disease; 8/11(72.7%) patients were considered in partial response by ΔDp evaluation and 3/11(27.3%) in stable disease; according ΔDt 7/11(63.6%) patients showed a partial response, 1/11(9.1%) showed progression of disease and 3/11(27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ2 test was observed. A good correlation was reported between ΔHounsfield unit and Δmaximum standardized uptake value and between Δfp and ΔWOS, with a significant statistically difference(P < 0.05) using Spearman correlation coefficient.CONCLUSION Perfusion and diffusion MR derived parameters, Choi, PERCIST criteria are more performant than morphological MR and CT criteria to assess ECT treatment response. | Vincenza Granata Roberta Fusco Sergio Venanzio Setola Mauro Piccirillo Maddalena Leongito Raffaele Palaia Francesco Granata Secondo Lastoria Francesco Izzo Antonella Petrillo | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 2 | Insulin resistance and vitaminB12therapy in patients with metabolic syndrome:relationship be-tween homocysteine levels and hyperinsulinemia显示文摘 | Setola E Monti LD Galluccio E | 2004 | Eur J En-docrinol2004，15，11： | 1 |
| 3 | A sliding manifold approach for vibration reduction of flexible systems显示文摘 | Cavallo A de Maria G Setola R | 1999 | Automatica1999，35，10： | 1 |
| 4 | Increased insulin-stimulated endothelin-1 release is a distinct vascular phenotype distinguishing Cushing's disease from metabolic syndrome显示文摘 | Setola E Losa M Lanzi R | 2007 | Clin Endocrinol (Oxf)2007，66，4： | 1 |
| 5 | Metabolic and endothelial effects of trimetazidine on foream skeletal muscle in patients with type 2diabetes and ischemic cardiomyopathy显示文摘 | Monti LD Setola E Fragasso G | 2006 | American Journal of Physiology Endocrinology and Metabolism2006，01，12： | 1 |
| 6 | Subcellular localization and axonal transport of the survival motor neuron(SMN)protein in the developing rat spinal cord显示文摘 | Pagliardini S Giavazzi A Setola V | | 0，，01： | 1 |
| 7 | Insulin resistance and vitamin B12 therapy in patients with metabolic syndrome:relationship between homocysteine levels and hyperinsulinemia显示文摘 | Monrti LD Galhccio E | 2004 | Ear J Endocrinol2004，151，4： | 1 |
| 8 | Effects of chronic elevation of atrial natriuretic peptide and free fatty acid levels in the induction of type 2 dia- betes mellitus and insulin resistance in patients with mitral valve disease显示文摘 | MONTI L D LUCOTTI P SETOLA E | 2012 | Nutrition Metabolism and Cardiovascular Diseases2012，22，1： | 1 |
| 9 | Metabolic and en- dothelial effects of trimetazidine on forearm skeletal mus- cle in patients with type 2 diabetes and ischemie car-diomyopathy显示文摘 | Monti LD Setola E Fragasso G | 2006 | Am J Physiol Endocrinol Metab2006，290，1： | 1 |
| 10 | Predicting new molecular tar- gets for known drugs显示文摘 | Keiser M J Setola V Irwin J J | 2009 | Nature2009，462，7270： | 1 |
| 11 | Predicting new molecular targets for known drugs显示文摘 | Keiser MJ Setola V Irwin JJ Laggner C Abbas AI Hufeisen SJ | | 0，，7270： | 1 |
| 12 | Con- trast-enhanced sonography of the kidney显示文摘 | Setola SV Catalano O Sandomenico F | 2007 | Abdom Imaging2007，32，： | 1 |
| 13 | An integrated ap- proach for simulating interdependencies 显示文摘 | SETOLA R BOLOGNA S CASALICCHIO E | 2009 | Critical Infrastructure Protection Ⅱ The International Federation for Information Pro- cessing2009，290，： | 1 |
| 14 | Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass显示文摘 | Lucotti P Monti L Setola E | 2009 | Metabolism2009，58，9： | 1 |
| 15 | Contrast enhanced sonography of the kidney显示文摘 | Setola SV Catalano 0 Sandomenico F etal | 2007 | Abdom lmaging2007，32，： | 1 |
| 16 | Contrast-enhanced sonography of the kidney显示文摘 | Setola SV Catalano O Sandomenico F | 2007 | Abdom Imaging2007，32，1： | 1 |
| 17 | Insulin resistaneta ce and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: rela tionship between homocysteine levels and hyperinsu-linemia 显示文摘 | Setola E Monti L D Galluccio E | 2004 | Eur J Endocrinol2004，151，4： | 1 |
| 18 | Sclerosing hemangioma of the lung mimicking pulmonary metastasis显示文摘 | De LG Martucci N Setola S | 2015 | Lung2015，193，3： | 1 |
| 19 | A sliding manifold approach for vibration reduction of flexible systems显示文摘 | Cavallo A Maria G De Setola R | 1999 | Automatica1999，，35： | 1 |
| 20 | Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies显示文摘 | Davies MA Setola V Strachan RT | | 0，，01： | 1 |
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