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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Electrospinning of curcumin loaded chitosan/poly (lactic acid) nanofilm and evaluation of its medicinal characteristics显示文摘curcumin 装载了 chitosan/poly (乳的酸)(PLA ) nanofibers 用 electrospinning 被生产。BoxBehnken 试验性的设计被用于变量的优化(1, 0, + 1 编码水平) 相似 chitosan/PLA 力量(% w/v ) , curcumin 力量(% w/v ) 和应用电压(kV ) 到获得一致纤维直径。nanofibers 的形态学被 SEM 显示出。分子的相互作用和 curcumin 的各化学的化合物的存在装载了 chitosan/PLA 纤维被 FTIR 和 EDX 分析描绘。抗氧化剂,药版本并且在 vitro cytotoxicity,测试被执行评估将被用于创伤愈合的 nanofibers 的适用性。在愈合弯屈在切除和切口上学习的 vivo,创伤在给创伤区域的重要减小看是否的老鼠模型上创造了与相比未经治疗。更好愈合的效率能被归因于 curcumin 和 chitosan 的存在。 | Bhaarathi DHURAI Nachimuthu SARASWATHY Ramasamy MAHESWARAN Ponnusamy SETHUPATHI Palanisamy VANITHA Sukumar VIGNESHWARAN~, and Venugopal RAMESHBABU | 2013 | Frontiers of Materials Science2013，7，4： | 2 |
| 3 | Magnetic and magnetotransport properties of Ce doped LaMnO3 显示文摘 | Krishnamoorthy C Sethupathi K Sankaranarayanan V | 2007 | Journal of Alloys and Compounds2007，438，： | 1 |
| 4 | Colossalmagnetoresistance in the double perovskite oxide La(2)CoMnO(6)显示文摘 | Mahato R N Sethupathi K Sankaranarayanan V | 2010 | J Appl Phys2010，107，09： | 1 |
| 5 | Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region:a mechanism for functional single-nucleotide polymorphisms related to phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 6 | Anti-apoptotic func- tion of a microRNA encoded by the HSV-1 latency-asso- ciated transcript 显示文摘 | Gppta A Gartner J J Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 7 | Human microRNA- 155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | AmJ Hum Genet2007，81，2： | 1 |
| 8 | Anti-apoptotic function of a microRNA encoded by the HSV-I latency-associated transcript显示文摘 | Gupta A Gartner JJ Sethupathy P | | 0，，7098： | 1 |
| 9 | Association of angiotensin converting enzyme gene insertion/deletion polymorphism with essential hypertension in south Indian population显示文摘Genetic,environmental and demographic factors contribute to the development of essential hypertension.Genetic polymorphism of Rennin-angiotensin-aldosterone system(RAAS)has been extensively studied to determine the genetic susceptibility to hypertension.The insertion/deletion(I/D)angiotensin converting enzyme(ACE)polymorphism has been established as a cardiovascular risk factor in some population,but its association with essential hypertension is controversial.This study sought to determine the association of I/D polymorphism of the ACE gene in south Indian essential hypertensive subjects.A total of 208 clinically diagnosed essential hypertensive patients without any associated diseases and 220 healthy control subjects were included in this study.Distribution and allelic frequency of Insertion(I)and Deletion(D)polymorphism at the 287 base pair Alu repeat sequence in the intron 16 of ACE gene were analyzed.The distribution of II,ID,DD genotypes of ACE gene was 28.3%,32.6%and 38.9%respectively in essential hypertensive patients and to 53.6%,26.3%and 20%in controls.The allele frequency for D allele is 0.58 in essential hypertension as compared to 0.34 of control subjects.The genotype and allele frequency of ACE gene polymorphism is significantly differed in patients when compared to controls.In conclusion,the I/D polymorphism of ACE gene is associated with Indian essential hypertension. | Ramalingam Krishnan Durairaj Sekar Santha karunanithy Sethupathy Subramanium | 2016 | Genes & Diseases2016，3，2： | 1 |
| 10 | Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisrns related to phenotypes 显示文摘 | Sethupathy P Borel C Gagnebin M et ai | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 11 | Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript显示文摘 | Gupta A Gartner JJ Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 12 | miR-182 and miR- 10a are key regulators of Treg specialisation and stability during schistosome and Leishmania-associated inflammation 显示文摘 | Kelada S Sethupathy P Okoye IS | 2013 | PLoS Pathog2013，9，10： | 1 |
| 13 | Selective catalytic reduction of nitric oxide over cerium-doped activated carbons 显示文摘 | Athappan A Sattler M L Sethupathi S | 2015 | J EnvironChem Eng2015，3，4： | 1 |
| 14 | miRGen:A database for the study of animal microRNA genomic organization and function显示文摘 | Megraw M Sethupathy P Corda B Hatzigeorgiou A G | | 0，，： | 1 |
| 15 | Redirection ofsilencing targets by adenosine-to-inosine editing of miRNAs显示文摘 | Kawahara Y Zinshteyn B Sethupathy P | 2007 | Science2007，315，58： | 1 |
| 16 | Induction of an HPV 6bL1-specific mucosal IgA response by DNA immunization显示文摘 | Schreckenberger C Sethupathi P Kanjanahaluethai A | 2000 | Vaccine2000，19，： | 1 |
| 17 | Anti-apoptotic function of a microRNAencoded by the HSV-1 latency-associatedtranscript 显示文摘 | Gupta A Gartner JJ Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 18 | TarBase: a compre- hensive database of experimentally supported animal miRNA targets显示文摘 | Sethupathy P Corda B Artemis G | 2006 | RNA2006，12，2： | 1 |
| 19 | Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire显示文摘 | Rhee KJ Sethupathi P Driks A | 2004 | J Immunol2004，172，2： | 1 |
| 20 | Human micro RNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functionai single-nucleotide polymorphisms re latedto phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | Am J Hum Genet2007，81，2： | 1 |
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