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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region:a mechanism for functional single-nucleotide polymorphisms related to phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 3 | Anti-apoptotic func- tion of a microRNA encoded by the HSV-1 latency-asso- ciated transcript 显示文摘 | Gppta A Gartner J J Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 4 | Human microRNA- 155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | AmJ Hum Genet2007，81，2： | 1 |
| 5 | Anti-apoptotic function of a microRNA encoded by the HSV-I latency-associated transcript显示文摘 | Gupta A Gartner JJ Sethupathy P | | 0，，7098： | 1 |
| 6 | Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisrns related to phenotypes 显示文摘 | Sethupathy P Borel C Gagnebin M et ai | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 7 | Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript显示文摘 | Gupta A Gartner JJ Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 8 | miR-182 and miR- 10a are key regulators of Treg specialisation and stability during schistosome and Leishmania-associated inflammation 显示文摘 | Kelada S Sethupathy P Okoye IS | 2013 | PLoS Pathog2013，9，10： | 1 |
| 9 | miRGen:A database for the study of animal microRNA genomic organization and function显示文摘 | Megraw M Sethupathy P Corda B Hatzigeorgiou A G | | 0，，： | 1 |
| 10 | Redirection ofsilencing targets by adenosine-to-inosine editing of miRNAs显示文摘 | Kawahara Y Zinshteyn B Sethupathy P | 2007 | Science2007，315，58： | 1 |
| 11 | Induction of an HPV 6bL1-specific mucosal IgA response by DNA immunization显示文摘 | Schreckenberger C Sethupathi P Kanjanahaluethai A | 2000 | Vaccine2000，19，： | 1 |
| 12 | Anti-apoptotic function of a microRNAencoded by the HSV-1 latency-associatedtranscript 显示文摘 | Gupta A Gartner JJ Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 13 | TarBase: a compre- hensive database of experimentally supported animal miRNA targets显示文摘 | Sethupathy P Corda B Artemis G | 2006 | RNA2006，12，2： | 1 |
| 14 | Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire显示文摘 | Rhee KJ Sethupathi P Driks A | 2004 | J Immunol2004，172，2： | 1 |
| 15 | Human micro RNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functionai single-nucleotide polymorphisms re latedto phenotypes显示文摘 | Sethupathy P Borel C Gagnebin M | 2007 | Am J Hum Genet2007，81，2： | 1 |
| 16 | A guide throughpresent computational approaches for the identification ofmammalian microRNA targets 显示文摘 | Sethupathy P Megraw M Hatzigeorgiou A G | 2006 | Nat Methods2006，3，11： | 1 |
| 17 | Anti-apoptotic function of a microRNA encoded by the HSV- 1 latency-associated transcript显示文摘 | Gupta A Gartner J J Sethupathy P | 2006 | Nature2006，442，7098： | 1 |
| 18 | Potential etiologic and functional implications of genome-wide association loci for hu- man diseases and traits显示文摘 | Hindorff LA Sethupathy P Junkins HA | 2009 | Proc Natl Acad Sei USA2009，106，23： | 1 |
| 19 | miR-182 and miR- 10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation 显示文摘 | Kelada S Sethupathy P Okoye IS | 2013 | PLoS Pathog2013，9，10： | 1 |
| 20 | Poten- tial etiologic and functional implications of genome-wide association loci for human diseases and traits 显示文摘 | Hindorff L A Sethupathy P Junkins H A | 2009 | Proc Natl Acad Sei U S A2009，106，23： | 1 |
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