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626篇 您的检索式:作者名="Seitz M"
    题名 作者 年代 出处 被引量
1Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy.Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz 2010World Journal of Gastroenterology2010,16,8:10
2Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik 2008Ultraschall in Med2008,,05:2
3显示文摘Wilbright T E Jaskolski S V Seitz M A 1970Proceeding of the IEEE1970,,58:1
4An individual based model for the conservation of the endangered Large Blue Butterfly, Maculinea arion显示文摘Griebeler E M Seitz A 2002Ecological Modelling2002,156,:1
5Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutro- phils显示文摘Seitz DH Perl M Marigold S 2008Shock2008,30,5:1
63' -fluoro-3' -deoxythymidine (- FLT) as positron emission tomography in a murine B-cell lymphoma model and in the human disease显示文摘Wagner M Seitz U Buck A 2003Cancer Res2003,63,10:1
7Cleaning, milling and baking tests with hard red winter wheat containing deoxynivalenol 显示文摘Seitz L M Eustace W D Mohr H E 1986Cereal Chemistry1986,63,:1
8Inducible expression of tissue factor in small-cell lung cancer: impact on morphology and matrix metalloproteinase secretion 显示文摘Hahn N Heiden M Seitz R 2012J Cancer Res Clin Oncol2012,138,4:1
9Underestimation of intraocular lens power for cataract sur- gery after myopic photorefractive keratectomy 显示文摘SEITZ B LANGENBUCHER A NGUYEN NX KUS MM KUCHI M 1999Ophthal- mology1999,106,4:1
10Enhanced in vitro induced production of interleukin 10 by peripheral blood mononuelear cells in rheumatoid arthritis is associated with clinical respense to methotrexate treatment显示文摘 Zwicker M Wider B 2001J Bheumatology2001,28,:1
11The proapoptotic Fas-associated factor 1 is specifically reduced in human gastric carcinomas显示文摘Bjφrling-Poulsen M Seitz G Guerra B 2003Int J Oncol2003,23,4:1
12Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes显示文摘Loetscher P Seitz M Baggiolini M 1996J Exv Med1996,184,:1
13single-columone purification and bio-characterization of recombinant human parathyroid hor mone-related protein (1~139)显示文摘Wu C Seitz PK Falzon M 2000Mol Cell Endocrinol2000,170,12:1
14Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors显示文摘BAS S PERNEGER T V SEITZ M 2002Rheumatology2002,41,7:1
15The distribution of lithium in peridotitic and pyroxenitic mantle lithologies: An indicator of magmatic and metasomatic processes显示文摘Seitz H M Woodland A B 2000Chemical Geology2000,166,1:1
16Photo tourism: exploring photo collections in 3D显示文摘SNAVELY N SEITZ S M SZELISKI R 2006ACM Trans on Graphics2006,25,3:1
17Endoscopic ultrasonography for assessment of the response to combined radiation therapy and chemotherapy in patients with esophageal cancer显示文摘Giovannini M Seitz JF Thomas P 1997Endoscopy1997,29,:1
18The use of markovian metapopulation models: a comparison of three methodsreducing the dimensionality of transition matrices 显示文摘Griebeler E M Seitz A 2001Theoretical Population Biology2001,60,:1
19Characterization of a hepati- tis B and hepatitis delta virus receptor binding site 显示文摘Engelke M Mills K Seitz S 2006Hepatol- ogy2006,43,:1
20A theory of shape by space carving显示文摘 S M Seitz 2000International Journal of Computer Vision2000,38,3:1
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