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| 1 | Narrow-band imaging with magnifying endoscopy for the evaluation of gastrointestinal lesions显示文摘Narrow band imaging(NBI) endoscopy is an optical image enhancing technology that allows a detailed inspection of vascular and mucosal patterns, providing the ability to predict histology during real-time endoscopy. By combining NBI with magnification endoscopy(NBI-ME), the accurate assessment of lesions in the gastrointestinal tract can be achieved, as well as the early detection of neoplasia by emphasizing neovascularization. Promising results of the method in the diagnosis of premalignant and malignant lesions of gastrointestinal tract have been reported in clinical studies. The usefulness of NBI-ME as an adjunct to endoscopic therapy in clinical practice, the potential to improve diagnostic accuracy, surveillance strategies and cost-saving strategies based on this method are summarized in this review. Various classification systems of mucosal and vascular patterns used to differentiate preneoplastic and neoplastic lesions have been reviewed. We concluded that the clinical applicability of NBI-ME has increased, but standardization of endoscopic criteria and classification systems, validation in randomized multicenter trials and training programs to improve the diagnostic performance are all needed before the widespread acceptance of the method in routine practice. However, published data regarding the usefulness of NBI endoscopy are relevant in order to recommend the method as a reliable tool in diagnostic and therapy, even for less experienced endoscopists. | Alina Boeriu Cristian Boeriu Silvia Drasovean Ofelia Pascarenco Simona Mocan Mircea Stoian Daniela Dobru | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，2： | 11 |
| 2 | Viscoelastic tests in liver disease: where do we stand now?显示文摘Hemostasis is a complex physiological process based on the balance between procoagulant and anticoagulant systems to avoid pathological bleeding or thrombosis.The changes in standard coagulation tests in liver disease were assumed to reflect an acquired bleeding disorder,and cirrhotic patients were considered naturally anticoagulated.In the light of the new evidence,the theory of rebalanced hemostasis replaced the old concept.According to this model,the hemostatic alteration leads to a unique balance between pro-coagulant,anticoagulant,and fibrinolytic systems.But the balance is fragile and may prone to bleeding or thrombosis depending on various risk factors.The standard coagulation tests[INR(international normalized ratio),platelet count and fibrinogen]only explore parts of the hemostasis,not offering an entire image of the process.Rotational thromboelastometry(ROTEM)and thromboelastography(TEG)are both point of care viscoelastic tests(VET)that provide real-time and dynamic information about the entire hemostasis process,including clot initiation(thrombin generation),clot kinetics,clot strength,and clot stability(lysis).Despite prolonged PT/INR(international normalized ratio of prothrombin time)and low platelet counts,VET is within the normal range in many patients with both acute and chronic liver disease.However,bleeding remains the dominant clinical issue in patients with liver diseases,especially when invasive interventions are required.VET has been shown to asses more appropriately the risk of bleeding than conventional laboratory tests,leading to decrial use of blood products transfusion.Inappropriate clotting is common but often subtle and may be challenging to predict even with the help of VET.Although VET has shown its benefit,more studies are needed to establish cut-off values for TEG and ROTEM in these populations and standardization of transfusion guidelines before invasive interventions in cirrhotic patients/orthotopic liver transplantation. | Alina Buliarca Adelina Horhat Tudor Mocan Rares Craciun Bogdan Procopet Zeno Sparchez | 2021 | World Journal of Gastroenterology2021，27，23： | 3 |
| 3 | Clinical and impression cytology findings of amniotic membrane and oral mucosal membrane transplantation for the management of socket contracture显示文摘AIM:To investigate and compare the cytopathological and clinical effects of amniotic membrane transplantation(AMT)and oral mucosal membrane transplantation(OMMT)in socket contraction.METHODS:Twelve patients who could not be fitted with ocular prosthesis due to socket contracture were included in this study.Seven patients underwent AMT and 5 patients underwent OMMT.Thirteen patients who had healthy sockets were included as control group.Depth of inferior fornix,degree of inflammation,extent of the socket contracture and socket volume were measured in the preoperative period and at sixth and twelfth weeks postoperatively.Impression cytology of conjunctival fornices and tear transforming growth factor beta-1(TGFβ1)levels were determined.RESULTS:In the AMT group,socket volume and lower fornix depth values were significantly higher(P=0.030and P=0.004 respectively)and inflammation levels and impression cytology stages(P=0.037 and P=0.022respectively)were significantly lower in postoperative period compared to preoperative period.In the OMMT group,no statistical differences were found in terms of clinical parameters,inflammation levels and impression cytology stages of preoperative versus postoperative values.Preoperative tear TGFβ1 levels were higher in AMT and OMMT groups compared to the control group(25.5 ng/mL,26.3 ng/mL and 21.7 ng/mL respectively).Decreased tear TGFβ1 levels were observed in both the AMT and OMMT groups postoperatively(median decrease value=2.1 ng/mL and 2.7 ng/mL respectively).CONCLUSION:AMT is associated with postoperative improvement in inferior fornix depth,socket volume,inflammation and impression cytology levels and may bea more proper alternative method than OMMT in the management of socket contracture. | Bengi Ece Kurtul Ugur Erdener Mehmet Cem Mocan Murat Irkec Mehmet Orhan | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 3 |
| 4 | Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?显示文摘Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy. | Tudor Mocan Adelina Horhat Emil Mois Florin Graur Cristian Tefas Rares Craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 5 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 6 | Quantitative endoskopische kontrastverst?rkte harmonische Sonografie zur Differenzierung solider Pankreastumoren显示文摘 | A. Seicean R. Badea R. Stan-Iuga T. Mocan I. Gulei O. Pascu | 2010 | Ultraschall in Med2010，，06： | 1 |
| 7 | Hyaluronic acid coated poly-epsilon-eaprolaetonenauospheres deliver high concentrations of cyelosporine A into the cornea显示文摘 | Yenice I Mocan MC Palaska E | 2008 | Exp Eye Res2008，87，3： | 1 |
| 8 | Elevated intravitreal interleukin-6 levels in patients with proliferative diabetic retinopathy显示文摘 | MOCAN M C KADAYIFCILAR S ELDEM B | 2006 | Can J Ophthalmol2006，41，： | 1 |
| 9 | Accuracy and rationality of state general fund revenue forecasts:evidence from panel data显示文摘 | MOCAN H N AZAD S | 1995 | International Journal of Forecasting1995，，11： | 1 |
| 10 | What Determines Corruption? International Evidence from Micro Data 显示文摘 | Mocan N | 2004 | Economic Inquiry2004，46，4： | 1 |
| 11 | Kasabach-Merrit syndrome in infants 显示文摘 | Sarihan H Mocan H Abeys M | 1998 | Panminerva Med1998，40，2： | 1 |
| 12 | Structural unemployment, cyclical unemployment, and income inequality 显示文摘 | Mocan N H | 1999 | Review of E- conomics and Statistics1999，81，1： | 1 |
| 13 | Delayed tear clearance in patients with conjunctive chalasis is associated with punctal occlusion显示文摘 | Erdogan-Poyraz C Mocan MC Irkec M | 2007 | Cornea2007，26，3： | 1 |
| 14 | The determinants of the will- ingness to donate an organ among young aduhs: evidence from the United States and the European Union 显示文摘 | Mocan N Tekin E | 2007 | Soe Sci Med2007，65，12： | 1 |
| 15 | Novel approaches in search for biomarkers of cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA)arises from the ductular epithelium of the biliary tree,either within the liver(intrahepatic CCA)or more commonly from the extrahepatic bile ducts(extrahepatic CCA).This disease has a poor prognosis and a growing worldwide prevalence.The poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging,especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA,or distal CCA and pancreatic head adenocarcinoma.Most patients present with an advanced disease,unresectable disease,and there is a lack in non-surgical therapeutic modalities.Not least,there is an acute lack of prognostic biomarkers which further complicates disease management.Therefore,there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result,either singlehandedly or combined with other methods.In the'-omics'era,this goal can be attained by various means,as it has been successfully demonstrated in other primary tumors.Numerous variants can reach a biomarker status ranging from circulating nucleic acids to proteins,metabolites,extracellular vesicles,and ultimately circulating tumor cells.However,given the relatively heterogeneous data,extracting clinical meaning from the inconsequential noise might become a tall task.The current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research. | Lavinia-Patricia Mocan Maria Ilieș Carmen Stanca Melincovici Mihaela Spârchez RareșCrăciun Iuliana Nenu Adelina Horhat Cristian Tefas Zeno Spârchez Cristina Adela Iuga Tudor Mocan Carmen Mihaela Mihu | 2022 | World Journal of Gastroenterology2022，28，15： | 1 |
| 16 | A new treatment with bleomycin for complicated cutaneous hemangioma in children显示文摘 | Sarihan H Mocan H Yildiz K | 1997 | Eur J Pediatr Surg1997，7，3： | 1 |
| 17 | Solving semantic interoperability conflicts in cross-border e-government services显示文摘 | Mocan A | 2009 | International Journal on Semantic Web and Information Systems2009，5，1： | 1 |
| 18 | Kala-azar in Trabzon (Eastern black sea) region of Turkey显示文摘 | H. Mocan Y. Gedik A. Okten E. Erduran N. Gacar | 1993 | The Indian Journal of Pediatrics1993，，6： | 1 |
| 19 | A new treatment with bleomycin for complicated cutaneous hemangioma in children 显示文摘 | Sarihan H Mocan H Yildiz K | 1997 | Eur J Pediatr Surg1997，79，3： | 1 |
| 20 | Plasma homocysteine and the severity of heart failure in patients with previous myocardial infarction 显示文摘 | Agoston - Coldea L Mocan T Gatfosse M | 2011 | Cardiol J2011，18，1： | 1 |
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