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| 1 | Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules显示文摘Nerve diseases including acute injury such as peripheral nerve injury(PNI),spinal cord injury(SCI)and traumatic brain injury(TBI),and chronic disease like neurodegeneration disease can cause various function disorders of nervous system,such as those relating to memory and voluntary movement.These nerve diseases produce great burden for individual families and the society,for which a lot of efforts have been made.Axonal pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the tissue.Following a traumatic injury,the intricate architecture suffers disruption leading to inhibition of growth and loss of guidance.Due to limited capacity of the body to regenerate axonal pathways,it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue regeneration.And for central nervous system injury,one more extra precondition is compulsory:creating a less inhibitory surrounding for axonal growth.Electrospinning is a cost-effective and straightforward technique to fabricate extracellular matrix(ECM)-like nanofibrous structures,with various fibrous forms such as random fibers,aligned fibers,3D fibrous scaffold and core-shell fibers from a variety of polymers.The diversity and versatility of electrospinning technique,together with functionalizing cues such as neurotrophins,ECM-based proteins and conductive polymers,have gained considerable success for the nerve tissue applications.We are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases. | Lingling Tian Molamma P.Prabhakaran Seeram Ramakrishna | 2015 | Regenerative Biomaterials2015，2，1： | 17 |
| 2 | A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications显示文摘Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950 s.Due to the excellent mechanical tribological properties,corrosion resistance,biocompatibility,and antibacterial properties of titanium,it is getting much attention as a biomaterial for implants.Furthermore,titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site.These properties are crucial for producing high-strength metallic alloys for biomedical applications.Titanium alloys are manufactured into the three types ofα,β,andα+β.The scientific and clinical understanding of titanium and its potential applications,especially in the biomedical field,are still in the early stages.This review aims to establish a credible platform for the current and future roles of titanium in biomedicine.We first explore the developmental history of titanium.Then,we review the recent advancement of the utility of titanium in diverse biomedical areas,its functional properties,mechanisms of biocompatibility,host tissue responses,and various relevant antimicrobial strategies.Future research will be directed toward advanced manufacturing technologies,such as powder-based additive manufacturing,electron beam melting and laser melting deposition,as well as analyzing the effects of alloying elements on the biocompatibility,corrosion resistance,and mechanical properties of titanium.Moreover,the role of titania nanotubes in regenerative medicine and nanomedicine applications,such as localized drug delivery system,immunomodulatory agents,antibacterial agents,and hemocompatibility,is investigated,and the paper concludes with the future outlook of titanium alloys as biomaterials. | Masoud Sarraf Erfan Rezvani Ghomi Saeid Alipour Seeram Ramakrishna Nazatul Liana Sukiman | 2022 | Bio-Design and Manufacturing2022，5，2： | 8 |
| 3 | Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration显示文摘Peripheral nerves are fragile and easily damaged,usually resulting in nervous tissue loss,motor and sensory function loss.Advances in neuroscience and engineering have been significantly contributing to bridge the damage nerve and create permissive environment for axonal regrowth across lesions.We have successfully designed two self-assembling peptides by modifying RADA 16-I with two functional motifs IKVAV and RGD.Nanofiber hydrogel formed when combing the two neutral solutions together,defined as RADA 16-Mix that overcomes the main drawback of RADA16-I associated with low pH.In the present study,we transplanted the RADA 16-Mix hydrogel into the transected rat sciatic nerve gap and effect on axonal regeneration was examined and compared with the traditional RADA16-I hydrogel.The regenerated nerves were found to grow along the walls of the large cavities formed in the graft of RADA16-I hydrogel,while the nerves grew into the RADA 16-Mix hydrogel toward distal position.RADA 16-Mix hydrogel induced more axons regeneration and Schwann cells immigration than RADA16-I hydrogel,resulting in better functional recovery as determined by the gait-stance duration percentage and the formation of new neuromuscular junction structures.Therefore,our results indicated that the functional SAP RADA16-Mix nanofibrous hydrogel provided a better environment for peripheral nerve regeneration than RADA16-I hydrogel and could be potentially used in peripheral nerve injury repair. | Xiaoli Wu Liumin He Wen Li Heng Li Wai-Man Wong Seeram Ramakrishna Wutian Wu | 2017 | Regenerative Biomaterials2017，4，1： | 6 |
| 4 | Surface modification of magnesium alloys using thermal and solid-state cold spray processes:Challenges and latest progresses显示文摘Potential engineering applications of magnesium(Mg)and Mg-based alloys,as the lightest structural metal,have made them a popular subject of study.However,the inferior corrosion and wear characteristics significantly limit their application range.It is widely recognized that surface treatment is the most commonly utilized technique for remarkably improving a substrate’s surface characteristics.Numerous methods have been introduced for the surface treatment of Mg and Mg-based alloys to improve their corrosion behavior and tribological performance.Among these,thermal spray(TS)technology provides several methods for deposition of various functional metallic,ceramic,cermet,or other coatings tailored to particular conditions.Recent researches have shown the tremendous potential for thermal spray coated Mg alloys for biomedical and industrial applications.In this context,the cold spray(CS)method,as a comparatively new TS coating technique,can generate the coating layer using kinetic energy rather than combined thermal and kinetic energies,like the high-velocity oxy-fuel(HVOF)spray method.Moreover,the CS process,as a revolutionary method,is able to repair and refurbish with a faster turnaround time;it also provides solutions that do not require dealing with the thermal stresses that are part of the other repair processes,such as welding or other TS processes using a high-temperature flame.In this review paper,the recently designed coatings that are specifically applied to Mg alloys(primarily for industrial applications)employing various coating processes are reviewed.Because of the increased utilization of CS technology for both 3D printed(additively manufactured)coatings and repair of structurally critical components,the most recent CS methods for the surface treatment,repair,and refurbishment of Mg alloys as well as their benefits and restrictions are then discussed and reviewed in detail.Lastly,the prospects of this field of study are briefly discussed,along with a summary of the presented work. | Mohammadreza Daroonparvar Hamid Reza Bakhsheshi-Rad Abbas Saberi Mahmood Razzaghi Ashish K Kasar Seeram Ramakrishna Pradeep L.Menezes Manoranjan Misra Ahmad Fauzi Ismail Safian Sharif Filippo Berto | 2022 | Journal of Magnesium and Alloys2022，10，8： | 4 |
| 5 | Emerging design principles,materials,and applications for moisture-enabled electric generation显示文摘Smart generators that collect energy from the ambient environment are a new approach for meeting growing global energy needs.Moisture is one of the most abundant resources in the ambient environment,and using it to generate electricity has aroused great interest in recent years.In this review,we first summarize the emerging design principles of moisture power generation,including ion diffusion,streaming potential,and charged surface potential.Then,based on these fundamental principles,we systematically summarize the materials thus far known to be suitable for moisture power generation.Finally,we highlight the application of moisture energy generators in various fields,such as thermoelectricity,solar thermal evaporation,capacitors,strain sensors,and information storage,and discuss current challenges and future prospects for the development of moisture energy generators. | Zhaoyang Sun Xian Wen Liming Wang Dongxiao Ji Xiaohong Qin Jianyong Yu Seeram Ramakrishna | 2022 | eScience2022，2，1： | 4 |
| 6 | Effects of nanotopography on stem cell phenotypes显示文摘Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues.In the stem cell niche,stem cell-extracellular matrix(ECM)interactions are crucial for different cellular functions,such as adhesion,proliferation,and differentiation.Recently, in addition to chemical surface modifications,the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs.This review describes the influence of nanotopography on stem cell phenotypes. | Rajeswari Ravichandran Clarisse CH Ng Casey K Chan Michael Raghunath Seeram Ramakrishna | 2009 | World Journal of Stem Cells2009，1，1： | 3 |
| 7 | Nanocomposites for electronic applications that can be embedded for textiles and wearables显示文摘In the present review, we have selected advances in electrospinning nanofibers that we envision to be embedded in textiles and wearables. These nanofibers have been proven to be excellent options for applications such as power generation, sensing, and communication. Their similitude with already known woven meshes makes these fibers perfect for electronically active textiles.These fibers offer well known characteristics such as mechanical flexibility, high surface area-to-volume ratio, light weight and can be tuned by carefully selecting the active materials in the precursor solution. Here we will discuss polymers with electroactive, piezoelectric, triboelectric and their composites that have been used in fiber structures by using the electrospinning technique. | SERRANO-GARCIA William JAYATHILAKA Wanasinghe Arachchige Dumith Madushanka CHINNAPPAN Amutha TRAN Thang Quyet BASKAR Chinnappan THOMAS Sylvia Wilson RAMAKRISHNA Seeram | 2019 | Science China(Technological Sciences)2019，62，6： | 3 |
| 8 | Perovskite Solar Fibers:Current Status,Issues and Challenges显示文摘Perovskite-based solar cells with high power conversion efficiencies(PCEs)are currently being demonstrated in solid-state device designs.Their elevated performances can possibly be attained with different non-standard geometries,for example,the fiber-shaped perovskite solar cells,in the light of careful design and engineering.Fiber-shaped solar cells are promising in smart textiles energy harvesting towards next-generation electronic applications and devices.They can be made with facile process and at low cost.Recently,fiber-shaped perovskite solar devices have been reported,particularly with the focus on the proof-of-concept in such non-traditional architectures.In this line,there are so many technical aspects which need to be addressed,if these photovoltaic(PV)cells are to be industrialized and produced massively.Herein,a well-organized and comprehensive discussion about the reported devices in this arena is presented.The challenges that need to be addressed,the possible solutions and the probable applications of these PV cells are also discussed.More still,the perovskite fiber-shaped PV cells with other fiber PV devices reported in literature in terms of their scope,characteristic designs,performances,and other technical considerations have been summarised. | Andrew Balilonda Qian Li Mike Tebyetekerwa Rogers Tusiime Hui Zhang Rajan Jose Fatemeh Zabihi Shengyuan Yang Seeram Ramakrishna Meifang Zhu | 2019 | Advanced Fiber Materials2019，1，2： | 3 |
| 9 | Advanced Electrospun Nanofibrous Materials for Efficient Oil/Water Separation显示文摘The frequent occurrence of crude oil leakage accidents and the massive discharge of industrial oily wastewater not only caused huge damage and pollution to the ecosystem but also wasted a lot of precious resources.Therefore,it is urgent to solve the worldwide problem of oil/water separation.As a leader in advanced fiber materials,nanofibrous materials prepared by electrospinning have the advantages of high permeability,high separation efficiency,large specific surface area,adjustable wettability,simple preparation process,and low cost,making it attracted more attention of researchers in oil/water separation.This article mainly reviews the recent progress of various electrospun nanofibrous materials for oil/water separation field.The preparation and synthesis of nanofibrous adsorbents,nanofibrous membranes,and nanofibrous aerogels in recent years based on different applications,design principles,and separation approaches are systematically summarized.Finally,this review discusses the challenges and future development directions in oil/water separation. | Ying Su Tingting Fan Wenying Cui Yanan Li Seeram Ramakrishna Yunze Long | 2022 | Advanced Fiber Materials2022，4，5： | 3 |
| 10 | Electrospun Nanofibers-Based Face Masks显示文摘Textiles have proved to be very important materials to human beings since the time immemorial.And,fibers are the basic building units of these materials.In this perspective we substantiate the uniqueness and capability of nanofibers as active layers in face masks,to protect people against the novel coronavirus disease(COVID-19).This time-sensitive letter introduces the mechanisms based on which their active filters function,the uniqueness of electrospun nanofibers in face masks and do-it-yourself(DIY)steps to realize a fully functional face mask at home. | Mike Tebyetekerwa Zhen Xu Shengyuan Yang Seeram Ramakrishna | 2020 | Advanced Fiber Materials2020，2，3： | 3 |
| 11 | Tailoring the structure of silicon-based materials for lithium-ion batteries via electrospinning technology显示文摘Silicon(Si)is one of the most promising anode materials for the next generation of lithium-ion battery(LIB)due to its high specific capacity,low lithiation potential,and natural abundance.However,the huge variation in volume during the storage of lithium,along with the low conductivity of element,are the main factors hindering its commercial application.Designing micro-nano structures as well as composites of heterogeneous materials have proven to be effective strategies to overcome these issues.Electrospinning technology is an affordable and scalablemethod for easily constructing a unique hierarchical micro-nano structurewhile realizing composites of heterogeneousmaterials.So far,many efforts have been made to solve the problems of Si-based anodes with general electrospinning.This review considers the technical fundamental and design strategies for electrospun Si-based nanofibers,including preparation processes,structural engineering,and lithiumstorage performance.The structure-performance relationship of various materials and the effects of compositing with heterogeneous materials are explored in detail.Finally,the remaining challenges are discussed,along with directions for future research.This review will provide inspiration for researchers in the design and manufacture of electrospun Si-based nanofibers for LIBs. | Aoming Huang Yanchen Ma Jian Peng Linlin Li Shu-lei Chou Seeram Ramakrishna Shengjie Peng | 2021 | eScience2021，1，2： | 3 |
| 12 | Rapid large scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry显示文摘 | N. Seeram R. Lee M. Hardy D. Heber | 2004 | Separation and Purification Technology2004，，1： | 2 |
| 13 | 功能化纤维素:PET纤维沸石分子筛复合材料对神经毒剂的解毒性研究(英文)显示文摘Presently activated carbon is used as an adsorptive material for chemical and biological warfare agents. It possess excellent surface properties such as large surface area, fire-resistance and plenty availability, but has disadvantages such as its heavy weight, low breathability (after adsorption of moisture) and disposal. In this paper, we propose to utilize novel electrospun polymeric nanostructures having zeolites as catalyst materials. In this respective, the electrospun polymer nanofibers would serve as the best possible substitutes to activated carbon based protective clothing applications. This is the first in the literature that reports the integration of these types of catalysts with nanofiberous membranes. Electrospinning of cellulose/polyethylene terephthalate (PET) blend nanofibers has been carried out. Zeolite catalysts (Linde Type A and Mordenite) for the detoxification of nerve agent stimulant-paraoxon, were prepared due to their relative simplicity of synthesis. The catalysts were then coated onto nanofiber membranes and their morphology was confirmed using SEM. This is the first report on the coating of nanofibers with zeolites and their successful demonstration against nerve agent stimulant. The UV absorption spectra clearly show the detoxification ability of the functionalized fibers and their potential to be used in textiles for protection and decontamination. | Agarwal Satya R Sundarrajan Subramanian Ramakrishna Seeram | 2012 | 无机材料学报2012，27，3： | 2 |
| 14 | Prospects for 3D bioprinting of organoids显示文摘Three-dimensional(3D)organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative therapies.However,lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies.3D bioprinting of organoids has recently emerged to address some of these impediments.In this review,we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and organoids.We also summarize the use of several vascularization strategies for the bioprinted organoids,that are critical for a complex tissue organization.To fully realize the translational applications of organoids in disease modeling and regenerative medicine,these areas in 3D bioprinting need to be appropriately harnessed and channelized. | Preety Rawal Dinesh M.Tripathi Seeram Ramakrishna Savneet Kaur | 2021 | Bio-Design and Manufacturing2021，4，3： | 2 |
| 15 | Cardiogenic differentiation of mesenchymal stem cells on elastomeric poly (glycerol sebacate)/collagen core/shell fibers显示文摘AIM: To facilitate engineering of suitable biomaterials to meet the challenges associated with myocardial infarction. METHODS: Poly (glycerol sebacate)/collagen (PGS/ collagen) core/shell fibers were fabricated by core/ shell electrospinning technique, with core as PGS and shell as collagen polymer; and the scaffolds were characterized by scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), contact angle and tensile testing for cardiac tissue engineering. Collagen nanofibers were also fabricated by electrospinning for comparison with core/shell fibers. Studies on cell-scaffold interaction were carriedout using cardiac cells and mesenchymal stem cells (MSCs) co-culture system with cardiac cells and MSCs separately serving as positive and negative controls respectively. The co-culture system was characterized for cell proliferation and differentiation of MSCs into cardiomyogenic lineage in the co-culture environment using dual immunocytochemistry. The co-culture cells were stained with cardiac specific marker proteins like actinin and troponin and MSC specific marker protein CD 105 for proving the cardiogenic differentiation of MSCs. Further the morphology of cells was analyzed using SEM.RESULTS: PGS/collagen core/shell fibers, core is PGS polymer having an elastic modulus related to that of cardiac fibers and shell as collagen, providing natural environment for cellular activities like cell adhesion, proliferation and differentiation. SEM micrographs of electrospun fibrous scaffolds revealed porous, beadless, uniform fibers with a fiber diameter in the range of 380 ± 77 nm and 1192 ± 277 nm for collagen fibers and PGS/collagen core/shell fibers respectively. The obtained PGS/collagen core/shell fibrous scaffolds were hydrophilic having a water contact angle of 17.9 ± 4.6° compared to collagen nanofibers which had a contact angle value of 30 ± 3.2°. The PGS/collagen core/shell fibers had mechanical properties comparable to that of native heart muscle with a young's modulus of 4.24 ± 0.7 MPa, while that of collagen nanofibers was comparatively higher around 30.11 ± 1.68 MPa. FTIR spectrum was performed to confirm the functional groups present in the electrospun scaffolds. Amide Ⅰ and amide Ⅱ of collagen were detected at 1638.95 cm -1 and 1551.64 cm -1 in the electrospun collagen fibers and at 1646.22 cm -1 and 1540.73 cm -1 for PGS/collagen core/shell fibers respectively. Cell culture studies performed using MSCs and cardiac cells co-culture environment, indicated that the cellproliferation significantly increased on PGS/collagen core/shell scaffolds compared to collagen fibers and the cardiac marker proteins actinin and troponin were expressed more on PGS/collagen core/shell scaffolds compared to collagen fibers alone. Dual immunofluorescent staining was performed to further confirm the cardiogenic differentiation of MSCs by employing MSC specific marker protein, CD 105 and cardiac specific marker protein, actinin. SEM observations of cardiac cells showed normal morphology on PGS/collagen fibers and providing adequate tensile strength for the regeneration of myocardial infarction. CONCLUSION: Combination of PGS/collagen fibers and cardiac cells/MSCs co-culture system providing natural microenvironments to improve cell survival and differentiation, could bring cardiac tissue engineering to clinical application. | Rajeswari Ravichandran Jayarama Reddy Venugopal Subramanian Sundarrajan Shayanti Mukherjee Seeram Ramakrishna | 2013 | World Journal of Cardiology2013，5，3： | 2 |
| 16 | On investigating the soda-lime shot blasting of AZ31 alloy:Effects on surface roughness,material removal rate,corrosion resistance,and bioactivity显示文摘In the present study,a novel method of surface finish improvement is proposed using shot blasting of soda lime(SBSL)beads on the Mg-AZ31 alloy.The effect of the soda blasting process parameters,such as blast pressure,stand-off distance,and blast duration,have been studied in-response of material removal rate(MRR)and surface roughness(SR)and corresponding statistical models have been obtained.The multi-objective optimization has also been performed to obtain parameters for maximum MRR and minimum SR.The corrosion behavior of the treated specimens has been performed to study their in-vitro biodegradability in simulated body fluid(SBF)for 1,3,7,10,15,and 21 days.The wettability study of the SBSL treated samples has been investigated using sessile drop methodology.Further,cell adhesion test has also been performed to study the biocompatibility characteristics of the SBSL treated samples using Huh7 liver cell lines.Based on obtained quantitative data as well as scanning electron microscopy analysis of treated samples,the SBSL treatment of the AZ31 alloy has been found highly useful in producing biocompatibility surfaces along with desirable morphological features. | Gurmider Singh Sunpreet Singh Chander Prakash Seeram Ramakrishna | 2021 | Journal of Magnesium and Alloys2021，9，4： | 2 |
| 17 | 超疏水亲油PDMS@mSiO_(2)-PP非织造布的制备及其油水分离性能显示文摘为了制备一种超疏水亲油的材料,通过硅烷偶联剂KH560对纳米二氧化硅进行改性,再将改性纳米二氧化硅(mSiO_(2))和低表面能的聚二甲基硅氧烷(PDMS)后处理聚丙烯(PP)熔喷非织造布,制备了一种绿色无污染超疏水亲油材料,并采用扫描电子显微镜、红外光谱仪、马尔文激光粒度仪、接触角测试仪、万能拉伸仪和油水分离等对超疏水亲油材料的结构及性能进行表征。结果表明:制得的超疏水亲油PDMS@mSiO_(2)-PP材料具有良好的力学性能;同时该材料的静态接触角最高达155.89°,对食用油、机油和石蜡油的最大吸油倍率分别为40.21 g/g、33.96 g/g和33.68 g/g,能够快速分离油水混合物,具备优异的超疏水性亲油性能。 | 刘延波 陈倩 杨波 RAMAKRISHNA Seeram | 2022 | 天津工业大学学报2022，41，6： | 2 |
| 18 | Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries显示文摘 | N.P. Seeram R.A. Momin M.G. Nair L.D. Bourquin | 2001 | Phytomedicine2001，，5： | 2 |
| 19 | Nanofibrous filtering media: Filtration problems and solutions from tiny materials显示文摘 | R.S. Barhate Seeram Ramakrishna | 2007 | Journal of Membrane Science2007，，1： | 2 |
| 20 | In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice显示文摘 | Navindra P. Seeram Lynn S. Adams Susanne M. Henning Yantao Niu Yanjun Zhang Muraleedharan G. Nair David Heber | 2005 | The Journal of Nutritional Biochemistry2005，，6： | 2 |
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