|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide显示文摘Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases.The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women. | Antonio Braga Paulo Mora Andréia Cristina de Melo Angélica Nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl | 2019 | World Journal of Clinical Oncology2019，10，2： | 15 |
| 2 | 家族性复发性葡萄胎存在遗传异质性显示文摘目的确定家族性复发性葡萄胎(familial recurrent hydatidiform mole ,FRHM)的染色体亲源性,并进行基因定位。方法对葡萄胎组织进行病理分析,并通过激光捕获显微切割(laser capture microdissec-tion,LCM)技术从蜡块组织切片中纯化葡萄胎组织,应用聚合酶链反应扩增微卫星标记,确定FRHM的染色体亲源性;用19q13 .4区域的25个微卫星标记进行单倍型检测,确定这两个家系中致病基因是否为已报道的基因座。结果两个FRHM均为双亲来源的完全性葡萄胎(biparental complete hydatidiform mole ,BiCHM) ,两个家系中的患者在19q13 .4区域中的大多数遗传标记位点上表现为杂合。结论 FRHM常常与BiCHM相关,这两例家系的致病基因不在19q13 .4区域,FRHM存在遗传异质性。 | 赵峻 向阳 黄尚志 万希润 崔全才 Seckl MJ Fisher RA | 2006 | 中华医学遗传学杂志2006，23，5： | 3 |
| 3 | Gestatianal trophoblastic neoplasia mangement:an update显示文摘 | Michael J Seckl | 2007 | Cur Opin Oncol2007，19，： | 1 |
| 4 | The impact of molecular genetic diagnosis on the management of women with hCG-producing malignancies显示文摘 | Rosemary A. Fisher Philip M. Savage Caitriona MacDermott Jane Hook Neil J. Sebire Iain Lindsay Michael J. Seckl | 2007 | Gynecologic Oncology2007，，3： | 1 |
| 5 | A Novel Requirement for Janus Kinases as Mediators of Drug Resistance Induced by Fi- broblast Growth Factor-2 in Human Cancer Cells显示文摘 | Carmo CR Lyons Lewis J Seckl MJ | 2011 | PLoS One2011，6，19： | 1 |
| 6 | Glucocorticoids and the ageing hippocampus显示文摘 | Hibberd C Yau JL Seckl JR | 2000 | J Anat2000，，1974： | 1 |
| 7 | Gestational trophoblastic disease显示文摘 | Seckl MJ Sebire N J Berkowitz RS | 2010 | Lancet2010，376，9742： | 1 |
| 8 | Gestational tropho- blastic disease 显示文摘 | Seckl M J Sebire N J Berkowitz R S | 2010 | Lancet2010，376，9742： | 1 |
| 9 | Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats显示文摘 | DRAKE A J WALKER B R SECKL J R | 2005 | American Journal of Physiology:Regulatory Integrative and Comparative Physiology2005，288，1： | 1 |
| 10 | Gestational trophoblastic disease 显示文摘 | Seckl MJ Sebire NJ | 2010 | Lancet2010，376，9742： | 1 |
| 11 | Altered vas- cular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure 显示文摘 | Hadoke PW Lindsay RS Seckl JR | 2006 | J Endocrinol2006，188，3： | 1 |
| 12 | Update on the diagnosis and management of gestational trophoblastic disease显示文摘 | Ngan HY Seckl MJ Berkowitz RS | 2015 | Int J Gynaecol Obstet2015，1312，： | 1 |
| 13 | Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells显示文摘 | Seckl MJ Schwam E | 2002 | Br J Cancer2002，86，7： | 1 |
| 14 | Embolization of bleeding residual uterine vascular malformations in patients with treated gestational trophoblastic tumors 显示文摘 | Lim AK Agarwal R Seckl M J | 2002 | Radiology2002，222，3： | 1 |
| 15 | Minireview : 11 beta - hydroxysteroid dehydrogenase type 1 - a tissue - specific amplifier of glucocorticoid action显示文摘 | Seckl JR Walker BR | 2001 | Endocrinology2001，142，4： | 1 |
| 16 | Minireview : 11 beta - hydroxysteroid dehydrogenase type 1 - a tissue - specific amplifie of glucocorticoid action 显示文摘 | Seckl JR Walker BR | 2001 | Endocrinology2001，142，4： | 1 |
| 17 | Gestational trophoblastic neoplasia management : an update 显示文摘 | Ngan S Seckl MJ | 2007 | Curt' Opion Oncol2007，19，5： | 1 |
| 18 | Prenatal stress,glucocorticoids and the programming of the brain显示文摘 | WELBERG LA SECKL JR | 2001 | J Neuroendocrinol2001，13，： | 1 |
| 19 | Glucocorticoids, feto-placental 11 beta-hydroxys- teroid dehydrogenase type 2, and the early life origins of a- dult disease 显示文摘 | Seckl JR | 1997 | Steroids1997，62，1： | 1 |
| 20 | Embolization of bleeding residual uterine vascular malformations in patients with treated gestational trophoblastic tumors显示文摘 | Lim AK Agarwal R Seckl MJ | 2002 | Radiology2002，222，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员