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| 1 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 2 | p21 and p27 immunoexpression in gastric well differentiated endocrine tumors(ECL-cell carcinoids)显示文摘AIM: To investigate the expression of cyclin-dependent kinase inhibitors p21 and p27 in gastric well differenti- ated endocrine tumors (GWDET) (ECL-cell carcinoids). METHODS: The expressions of p21 and p27 were ex- amined immunhistochemically in endoscopic biopsy specimens from 16 patients matching the diagnostic criteria of GWDET. Percentage of positive nuclear stain- ing either weak or strong was noted. The association of immunoexpressions with age, gender, tumor localization, multifocality and accompanying chronic atrophic gastritis, neuroendocrine cell hyperplasia (NEH), neuroendocrine dysplasia (NED), intestinal metaplasia (IM), Ki-67 prolif- eration index and clinical outcome were also evaluated. RESULTS: All cases expressed p27 with a mean expres- sion score of 43.6%, while 31.3% of the cases showed any p21 expression. p21 and p27 immunoexpressions were significantly correlated with each other (P < 0.01), and the p21-expressing group had higher p27 expres- sion scores (68% vs 22%). p21 and p27 expressions were lower in women, in non-atrophic mucosa and cases whose tumors were located somewhere other than fun- dus without submucosal extension. On contrary, p21 and p27 expressions were higher in males and the patients with submucosal extension and atrophic gastritis. Cases presenting lower p27 scores had solitary tumors showing neither NEH-NED nor IM. Despite, cases with lower p21 expression presented multifocal tumors accompanied by NEH-NED. However, no correlation of p21 and p27 expres- sions was found with age and Ki-67 expression. CONCLUSION: p27 is widely expressed in GWDETs, while p21 expression is sparse and observed in two thirds of the cases. Loss of p21 and p27 expressions may be cor- related with different carcinoid tumor subtypes; however,m ore studies are needed to assess the role of these pro- spective markers in gastrointestinal endocrine tumors. | Basak Doganavsargil Banu Sarsik Fatma Secil Kirdok Ahmet Musoglu Muge Tuncyurek | 2006 | World Journal of Gastroenterology2006，12，39： | 2 |
| 3 | Congenital seminal vesicle cyst accompanying ipsilateral renal agenesis and rudimentary ureter显示文摘 | Cihanl A Cimen S Secil M | 2006 | Int Urol Nephrol2006，38，1： | 1 |
| 4 | Combined Segmental and Focal Adenomyomatosis Involving the Body of the Gallbladder显示文摘 | Secil M Karasu S Sago IO | 2005 | J Clin Ultrasound2005，33，5： | 1 |
| 5 | Echo contrast-enhanced pow- er Doppler uhrasonography for assessment of angiogenesis in renal cell carcinoma 显示文摘 | Kabakci N Igei E Secil M | 2005 | J Ultrasound Med2005，24，： | 1 |
| 6 | Combined Segmental and Focal Adenomyomatosis Involving the Body of the Gallbladder显示文摘 | Secil M Karasu S Sagol O | 2005 | J Clin Ultrasound2005，33，5： | 1 |
| 7 | A new method for the evaluation of erectile dysfunction:sildenafil plus Doppler ultrasonography显示文摘 | Arslan D Esen A Secil M | 2001 | J Urol2001，166，： | 1 |
| 8 | Effect of fatigue on biaxial flexural strength of bilayered porcelain/zirconia (Y-TZP) dental ceramics显示文摘 | Handan Yilmaza Secil Karakoca Nemlia | 2011 | Dental Materials2011，27，8： | 1 |
| 9 | Cone-beam CT evaluation of morphology, location, and courseof mandibular incisive canal: considerations for implant treatment显示文摘 | Kaan Orhan Murat Icen Secil Aksoy | 2014 | Oral Radiol2014，30，1： | 1 |
| 10 | Various radiological appearances of angiomyolipomas in the same kidney显示文摘 | Obuz F Karabay N Secil M | 2000 | Eur Radiol2000，10，6： | 1 |
| 11 | Serum cardiac markers in patients with acute myocardial infarction:oxidative stress,C-reactive protein and N-terminal probrain natriuretic peptide显示文摘 | Secil K Aymelek G Derya E | 2007 | J Clin Biochem2007，41，1： | 1 |
| 12 | Various radiological appearances of angiomyolipomas in the same kidney显示文摘 | Obuz F Karabay N Secil M | 2000 | Eur Radiol2000，10，3： | 1 |
| 13 | Echo contrast - enhanced powe Doppler ultrasonography for assessment of angiogenesis in renal cell carcinoma 显示文摘 | Kabakci N Igci E Secil M | 2005 | J Ultrasound Med2005，24，6： | 1 |
| 14 | A new method for the evaluation of erectile dysfunction:sildenafil plus Doppler ultrasonography显示文摘 | Arslan D Esen AA Secil M | 2001 | J Urol2001，166，： | 1 |
| 15 | Prospective evaluation of tumor size and hormonal status in adrenal incidentalomas显示文摘 | Yener S Ertilav S Secil M | 2010 | Journal of Endocrinological Investigation2010，33，1： | 1 |
| 16 | Various radiological appearanees of angiomyolipomas in the same kidney 显示文摘 | Obuz F Karabay N Secil M | 2000 | Eur Radiol2000，10，6： | 1 |
| 17 | Prediction of fracture behavior of steel beam-to-column connections with weld defect using the SINTAP 显示文摘 | BINNUR G K SECIL E | 2005 | Engineering Structures2005，27，： | 1 |
| 18 | Various radiological ap pearanees of angiomyolipomas in the same kidney 显示文摘 | Obuz F Karabay N Secil M | 2000 | Eur Radiol2000，10，6： | 1 |
| 19 | Pharyngocutaneous fistula following total laryngectomy: multivariate analysis of risk factors显示文摘 | Mehmet Ali Erdag Secil Arslanoglu Kazim Onal Murat Songu Abdurrahman Onur Tuylu | 2013 | European Archives of Oto-Rhino-Laryngology2013，，： | 1 |
| 20 | Ligandless cloud point extraction of Cr(III) , Pb (It) , Cu (II) , Ni (II) , Bi (III ) , and Cd (II) i- ons in environmental samples with Tween 80 and flame atomic absorption spectrometric determination显示文摘 | Secil Candir Ibrahim Narin Mustafa Soylak | 2008 | Talanta2008，77，： | 1 |
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