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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Small for gestationalage births among South Indian women : Temporal trend and riskfactors from 1996 to 2010 显示文摘 | Sebastian T Yadav B Jeyaseelan L | 2015 | BMC Pregnancy Childbirth2015，15，1： | 1 |
| 3 | Microbes and mucosal immune responses in asthma显示文摘 | Trevor T Hansel Sebastian L Johnston Peter J Openshaw | 2013 | The Lancet2013，，： | 1 |
| 4 | Superconductivity up to 29 K inSrFe2As2 and BaFe2As2 at high pressures显示文摘 | Patricia L Alireza Y T Chris Ko Jack Gillett Chiara M Petrone Jacqueline M Cole Gilbert G Lonzarich Suchitra E Sebastian | 2009 | Journal of Physics: Condensed Matter2009，，1： | 1 |
| 5 | Effect of non-magnetic inclusions in magnetic specimens on defect detec- tion sensitivity using active infrared thermography显示文摘 | Lahiri B B Bagavathiappan S Sebastian L T | 2014 | Infrared Physics and Technology2014，68，： | 1 |
| 6 | Combination of Tumor Site-Located CTL-Associated Antigen-4 Blockade and Systemic Regulatory T-Cell Depletion Induces Tumor-Destructive Immune Responses 显示文摘 | Sebastian T Bing-Mae C Ying L | 2007 | Cancer Res2007，67，12： | 1 |
| 7 | Low loss dielectrics in theCa(B'1/2Nb1/2)O3system显示文摘 | Khalam L A Sebastian M T | 2007 | Journal ofthe American Ceramics Society2007，90，5： | 1 |
| 8 | Optimal Replication and the Importance of Experimental Design for Gel-based Quantitative Proteomics显示文摘 | HUNT S M N THOMAS M R SEBASTIAN L T | 2005 | Journal of Proteome Research2005，4，3： | 1 |
| 9 | Structural evolution of the Piqiang Fault Zone,NW Tarim Basin,China显示文摘 | Sebastian A T Jian G L John W C | 2011 | Journal of Asian Earth Sciences2011，40，： | 1 |
| 10 | New birth weight reference standards customised to birth order and sex of babies from South India 显示文摘 | Kumar VS Jeyaseelan L Sebastian T | 2013 | BMC Pregnancy Childbirth2013，13，： | 1 |
| 11 | Co-sintered PZT Ceramics for the Piezoelectric Transformers显示文摘 | Sebastian T Kozielski L Erhart J | 2015 | Ceramics International2015，41，8： | 1 |
| 12 | Preparation, Characterization and Dielectric Properties of Ba3Ln3Ti5Nb5O30 (Ln=La, Nb) Ceramics显示文摘 | Koshy P Kumari L P Sebastian M T | 1998 | Journal of Materials Science: Materials in Electronics1998，9，1： | 1 |
| 13 | Genetic transformation of Diaporthe phaseolorurn, an endophytic fungus found in mangrove forests, mediated by Agrobacterium tumefaciens 显示文摘 | Sebastianes F L S Lacava P T Ftvaro L C L | 2012 | Current Genetics2012，58，1： | 1 |
| 14 | Advances in field emission displays phosphors显示文摘 | Holloway P H Trottier T A Abrams B Kondoleon C Jones S L Sebastian J S Thomes W J | | 0，，： | 1 |
| 15 | The novel structure of a cytosolic M14 metallocarboxypeptida-se(CCP)from Pseudomonas aeruginosa:a model for mammalian CCPs显示文摘 | ANABEL O MNICA R D L V SEBASTIAN T | 2012 | FASEB J2012，26，9： | 1 |
| 16 | Right ventricular apex versus right ventricular outflow tract pacing: prospective, randomised, long-term clinical and echocardiographic evaluation 显示文摘 | Ewa L N Alicja D K Sebastian T | 2006 | Cardiologia Polska2006，64，10： | 1 |
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