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| 1 | Geochronology of middle Neoproterozoic volcanic deposits in Yangtze Craton interior of South China and its implications to tectonic settings显示文摘Here we report new SHRIMP dating results of the crystal tuff in Ejiaao Formation of middle Banxi Group in northern Guizhou. The results indicate that the volcanic deposition occurred at ~780 Ma. We also suggests that the igneous activities across Yangtze Craton with diabase dyke swarms and basal volcanic rocks during middle Banxi time are indicative of the episodic, extensive and vigorous great bimodal igneous events during middle Neoproterozoic (825-720 Ma) in South China. The characteristics of the igneous series are contrary to the model claiming they are of island-arc origin, but suggest that they are the records of rifting process and may be related to the episodic plume activities leading to the break-up of Rodinia. | WANG ZhengJiang1, WANG Jian1, DUAN TaiZhong2, XIE Yuan1, ZHUO JieWen1,3 & YANG Ping1 1 Chengdu Institute of Geology and Mineral Resources, Ministry of Land and Resources, Chengdu 610082, China 2 Marathon Oil UK Ltd., Aberdeen, Scotland, AB15 6FZ, UK 3 Graduate Department, Chinese Academy of Geological Sciences, Beijing 100037, China | 2010 | Science China Earth Sciences2010，53，9： | 20 |
| 2 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 3 | Detection and differentiation of gene for toxin co-regulated pili(tcpA) in Vibrio cholerae non-O1using the polymerase chain reaction显示文摘 | Said B Smith HR Scotland SM | 1995 | FEMS Microbiol Lett1995，125，23： | 1 |
| 4 | Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response显示文摘 | Sesen J Dahan P Scotland SJ | 2015 | PLoS One2015，10，01： | 1 |
| 5 | Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-I double-knockout mice:key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo显示文摘 | Scotland RS Madhani M Chauhan S | 2005 | Circulation2005，111，6： | 1 |
| 6 | C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression 显示文摘 | Scotland R S Cohen M Foster P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 7 | The kelvin-helmholtz instability for a viscous interface显示文摘 | Lindsay K A Glasgow Scotland | 1984 | Acta mechanica1984，52，： | 1 |
| 8 | Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia显示文摘 | Shepherd J cobbe SM Ford T Iskes CG For the west of Scotland coronary prevention study Group | 1995 | N Eng J Med1995，333，： | 1 |
| 9 | Targeted theralies in bonesarcomas显示文摘 | Scotland K Picci P Kovar H | 2009 | Curr Cancer Drug Targets2009，9，7： | 1 |
| 10 | Aldosterone: cardiovascular assault显示文摘 | STRUTHERS AD SCOTLAND D | 2002 | Am Heart J2002，144，51： | 1 |
| 11 | The androgen receptor and stem cell pathways in prostate and bladder cancers (review) 显示文摘 | Marcinkiewicz K Scotland KB Boorjian SA | 2012 | Int J Oncol2012，40，1： | 1 |
| 12 | Denosumab for theprevention of osteoporotic fractures in post-menopausal women : aNICE single technology appraisal 显示文摘 | Scotland G Waugh N Royle P | 2011 | Pharmacoeconomics2011，29，11： | 1 |
| 13 | Higher-level systematics of Acanthaceae determined by chloropladt DNA sequences 显示文摘 | Scotland R W Sweere J A Reeves P A | 1995 | Amer J Bot1995，82，： | 1 |
| 14 | The androgen re- ceptor and stem cell pathways in prostate and bladder cancers(review) 显示文摘 | Marcinkiewcz K Scotland KB Booriian SA | 2012 | IntJ Oncol2012，40，1： | 1 |
| 15 | Properties of Vero cytotoxin-producing Escherichia coli of human origin of O serogroups other than O157显示文摘 | Willshaw GA Scotland SM Smith HR | 1992 | J Infect Dis1992，166，4： | 1 |
| 16 | Influence of pravastatin plasma lipids on clinical events in the west of Scotland coronary prevention study (woscops) 显示文摘 | The west of Scotland coronary prevention study Group | 1998 | Circulation1998，97，： | 1 |
| 17 | A coronary primary prevention study of Scottish men aged 45 -64 years: Trial design显示文摘 | The West of Scotland Coronary Prevention Study Group | 1992 | J Clin Epidemiol1992，45，8： | 1 |
| 18 | Influence of pravastatin and plasma lipids on clinical events in the west of Scotland coronary prevention study (WOSCOPS)显示文摘 | West of Scotland Coronary Prevention Study Group | 1998 | Circulation1998，97，： | 1 |
| 19 | C-type natriuretic peptide in vascular physiology and disease显示文摘 | Scotland RS Ahluwalia A Hobbs AJ | 2005 | Pharma Thera2005，105，： | 1 |
| 20 | Influence of pravastatin and plasma lipids on clinical events in the west of Scotland coronary prevention study (WOSCOPS)显示文摘 | West of Scotland coronary prevention study group | 1998 | Circulation1998，97，15： | 1 |
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