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| 1 | First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil显示文摘Corynespora cassiicola is the causal agent of Corynespora Leaf Fall(CLF)disease.CLF is one of the most important fungal diseases of rubber trees in Asia and Africa but disease outbreaks have not been reported in South America.Cassiicolin,a small cysteine-rich glycoprotein secreted by the pathogenic C.cassiicola isolate CCP,was previously identified as a potential disease effector in rubber tree.Recently,the cassiicolin-encoding gene(Cas1)was characterized and shown to be expressed in the early phase of infection.In this study,we investigated whether previously undetected strains of C.cassiicola are present in South American rubber plantations by examining the fungal endophyte population found in asymptomatic rubber tree leaves.Four isolates were identified as C.cassiicola.Genes encoding new forms of the cassiicolin precursor protein(Cas3 and Cas4)were identified from these isolates.Three of four isolates were able to induce symptoms on the cultivar they were isolated from in a detached leaf assay,with different kinetics and intensities.One isolate had the same pathogenicity profile as the pathogenic isolate CCP;the other two isolates developed symptoms late during the course of infection,suggesting saprotrophic capabilities.However,no Cas3 or Cas4 transcripts could be detected upon inoculation with the endophytic isolates,whereas the reference gene Cas1 was expressed upon inoculation with the CCP isolate.This work demonstrated that C.cassiicola is present in South America in an endophytic form and that it may evolve from an endophytic to a saprophytic or even potentially pathogenic life style. | Marine Déon Ana Scomparin Aude Tixier Carlos R.R.Mattos Thierry Leroy Marc Seguin Patricia Roeckel-Drevet Valérie Pujade-Renaud | 2012 | Fungal Diversity2012，，3： | 2 |
| 2 | Quality of life in chronic venous insufficiency : an Italian pilot study of the Triveneto region 显示文摘 | Andreozzi GM Cordova RM Scomparin A | 2005 | Int Angiol2005，24，： | 1 |
| 3 | Auto- nomic activity and glycemic homeostasis are maintained by pre- cocious and low intensity training exercises in MSG-pro- grammed obese mice显示文摘 | SCOMPARIN D X GOMES R M GRASSIOLLI S | 2009 | Endocrine2009，36，3： | 1 |
| 4 | Administration, distribution, metabolism and elimination of polymer therapeutics显示文摘 | Ela Markovsky Hemda Baabur-Cohen Anat Eldar-Boock Liora Omer Galia Tiram Shiran Ferber Paula Ofek Dina Polyak Anna Scomparin Ronit Satchi-Fainaro | 2011 | Journal of Controlled Release2011，，2： | 1 |
| 5 | Nov-el folated and non-folated pullulan bioconjugates for anticancerdrug delivery显示文摘 | Anna Scomparin Stefano Salmaso Sara Bersani | 2011 | European Journal of Pharmaceutical Sc-iences2011，42，5： | 1 |
| 6 | Nano-sized polymers and liposomes designed to deliver combination therapy for cancer 显示文摘 | Eldar-Booek A Polyak D Scomparin A | 2013 | Curr Opin Biotech2013，24，4： | 1 |
| 7 | Low-Intensity swimming training after weaning improves glucose and lipid homeostasis in MSG hypothalamic obese mice 显示文摘 | Scomparin DX Grassiolli S Gomes RM et at | 2011 | Endocr Res2011，36，： | 1 |
| 8 | Low-Intensity swimming training after weaning improves glucose and lipid homeostasis in MSG hypothalamic obese mice显示文摘 | Scomparin DX Grassiolli S Gomes RM | 2011 | Endocr Res2011，36，2： | 1 |
| 9 | Tailored PEG for rh-G-CSF analogue site-specific conjugation 显示文摘 | Salmaso S Bersani S Scomparin A | 2009 | Bioconj Chem2009，20，： | 1 |
| 10 | Nano- sized polymers and liposomes designed to deliver com- bination therapy for cancer显示文摘 | Eldar-Boock A Polyak D Scomparin A | 2013 | Curr Opin Biotechnol2013，24，4： | 1 |
| 11 | Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center显示文摘Objective: Probe-based confocal laser endomicroscopy(pCLE) technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution in vivo images at the cellular and microvascular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric lesions.Methods: Twenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Diagnostic pCLE was followed by biopsies or endoscopic resection of suspected lesions. A senior pathologist evaluated the specimens and was blinded to the pCLE results.Results: Patients' mean age was 68.3(range, 42-83) years and six were men. Thirteen suspicious flat or elevated lesions(classified as 0-Is, 0-IIa or 0-IIa + IIc) and seven pre-malignant lesions(atrophy and intestinal metaplasia)were evaluated. One patient was studied during his long-term follow-up after partial gastrectomy and presented severe atrophy, intestinal metaplasia, and xanthomas at the stump mucosa. The location of gastric lesions was in the body(n=10 lesions), the antrum(n=9) and the incisura angularis(n=1). All neoplastic lesions and all but one benign lesion were properly diagnosed by pCLE. pCLE incorrectly diagnosed one small antrum lesion as adenoma,however the final diagnosis was intestinal metaplasia. The final histological diagnosis was neoplastic in 9 and benign lesions in 11. In this small case series, pCLE accuracy was 95%(19/20 lesions).Conclusions: pCLE is accurate for real time histology of gastric lesions. pCLE may change the management of patients with gastric mucosal lesions, guiding biopsies and endoscopic resection, and avoiding further diagnostic workup or unnecessary therapy. | adriana vaz safatle-ribeiro elisa ryoka baba rodrigo corsato scomparin sheila friedrich faraj marcelo simas de lima luciano lenz bruno costa martins carla gusmon fábio shiguehissa kawaguti caterina pennacchi bruno zilberstein ulysses ribeiro jr. fauze maluf-filho | 2018 | Chinese Journal of Cancer Research2018，30，5： | 0 |
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