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| 1 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 2 | Biological properties of recombinant chicken interferon-gamma 显示文摘 | Weining K C Schultz U Munster U | 1996 | Immanol1996，26，10： | 2 |
| 3 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 4 | Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates显示文摘 | Stief TW Jeske WP Walenga J Schultz C Kretschmer V Fareed J | 2001 | Clin Appl Thromb Hemost2001，7，3： | 1 |
| 5 | Yolk sac ab- sorption and initiation of growth m broilers显示文摘 | Chamblee T N Brake J D Schultz C D | 1992 | Poul Sci1992，71，： | 1 |
| 6 | Primary adenocarcinoma of the urinary bladder ,a clinicopathological and prognostic study 显示文摘 | Anderstrom C Joganssonn SL Von Schultz | 1983 | Cancer1983，52，： | 1 |
| 7 | Joint cartilage regeneration by tissueengineering显示文摘 | Sittinger M Perka C Schultz O | 1999 | Rheumato1999，58，3： | 1 |
| 8 | Point muta- tions in the S protein connect the sialic acid binding activity with the enteropathogenicity of transmissible gastroenteritis coronavirus 显示文摘 | Krempl C Schultze B Laude H Herrler G | 1997 | J Virol1997，71，4： | 1 |
| 9 | Adding new chemistries to the genetic code显示文摘 | Liu C C Schultz P G | 2010 | Annu Rev Biochem2010，79，1： | 1 |
| 10 | Ketamine with and without midazolam for emergency department sedation in adults:a randomized controlled trial显示文摘 | Sener S Eken C Schultz CH | 2011 | Annals of Emergency Medicine2011，57，10： | 1 |
| 11 | Neural mecha-nisms of observational learning显示文摘 | Burke C J Tobler P N Baddeley M Schultz W | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 12 | Learning sequential decision rules using simulation models and competition显示文摘 | GREFENSTETTE J J RAMSEY C L SCHULTZ A C | 1990 | Machine Learning1990，5，： | 1 |
| 13 | Role of folic acid in modulating the toxicity and efficacy of the muhitargeted antifolate, LY231514 显示文摘 | Worzalla JF Shih C Schultz RM | 1998 | Anticancer Res1998，18，5： | 1 |
| 14 | Identification of a new class of small molecules that efficiently reactivate latent Epstein - Barr virus显示文摘 | Tikhmyanova N Schultz D C Lee T | 2014 | ACS chemical biology2014，9，3： | 1 |
| 15 | Maturatianal changes of lymphocyte surface antigens in human blood: comparison between fetuses, neonates and adults显示文摘 | Schultz C Reiss I Bucsky P | 2000 | Biol Neonate2000，78，： | 1 |
| 16 | Modeling and parametric study of torque in open clutch plates 显示文摘 | APHALE C R CHO J SCHULTZ W W | 2006 | Journal of Tribology2006，128，4： | 1 |
| 17 | Laparoscopic inguinal hernia repair显示文摘 | Schultz C Baca I Gotzen V | 2001 | Surg Endosc2001，15，6： | 1 |
| 18 | Demographics and diagnosis of pyridoxinedependent seizures显示文摘 | Ebinger M Schultze C K(o)nig S | | 0，，06： | 1 |
| 19 | Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10 deficient mice显示文摘 | SCHULTZ M VELTKAMP C DIELEMAN L A | | 0，，02： | 1 |
| 20 | The Spirituality Questi onnaire:Core Dimensions of Spirituality显示文摘 | Hardt J Schultz S Xander C | 2012 | Psychology2012，，3： | 1 |
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