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| 1 | Probiotics and prebiotics in chronic inflammatory bowel diseases显示文摘The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn’s disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefi ts conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A signifi cant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD. | Julia B Ewaschuk Levinus A Dieleman | 2006 | World Journal of Gastroenterology2006，12，37： | 41 |
| 2 | Helizarin~EVO P-100涂料型数码印花墨水显示文摘用于纺织品的涂料型墨水溶液的开发是一个很复杂的领域,在这个领域中目前使用的系统都是根据不同的喷墨印花喷头所采用的技术而度身定制的。其中用于涂料型墨水的新型高分子分散剂,能使纺织品的涂料型墨水具有低粘度的特性,从而适用于压电式喷墨印花喷头。使用新型的纺织品用涂料型喷墨印花墨水(HelizarinEVOP100inks)生产的喷射印花产品效果可与传统的纺织品涂料网印印花媲美。 | John Provost Cedric Dieleman Mike Freche Michael Kluge Juergen Weiser | 2005 | 印染2005，31，10： | 9 |
| 3 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 4 | 螺内酯与上消化道出血事件的风险:人群为基础的病例对照研究显示文摘目的确认并量化螺内酯与上消化道出血和溃疡之间的联系。设计人群为基础的病例对照研究。背景环境荷兰的初级保健信息数据库。参加者数据库中从1996年1月1日至2003年9月30日,所有年龄大于等于18岁的人。排除曾有酒精中毒或消化道肿瘤病史的患者。每个胃十二指肠溃疡或上消化道出血的病例配比十个对照,按年龄(出生年)、性别和索引日期进行匹配。主要结果评价使用条件 Logistic 回归分析,根据潜在的混杂因子对上消化道事件(出血或穿孔)的发生做出校正。结果在源人群中的306645位患者中,确认523个胃十二指肠溃疡或上消化道出血病例,与5230个对照进行配比。正在应用螺内酯治疗与消化道事件风险胜增加2.7倍相关联(95%可信区间1.2~6.0)。结论胃十二指肠溃疡或上消化道出血发生风险在使用螺内酯的患者中明显增加。 | Katia Verhamme Georgio Mosis Jeanne Dieleman Bruno Stricker Miriam Sturkenboom 史济华 | 2007 | 英国医学杂志中文版2007，10，1： | 2 |
| 5 | Urban Form and TravelBehavior: Micro-level Household Attributes and Residential Context 显示文摘 | Dieleman F Dijst M Burghouwt G | 2002 | Urban Studies2002，39，3： | 1 |
| 6 | Genetic and QTL analyses of yield and a set of physiological traits in pepper 显示文摘 | Alimi N A Bink M Dieleman J A | 2013 | Euphytica2013，190，2： | 1 |
| 7 | Policies for Urban Form and Their Impact on Travel: The Netherlands Experience 显示文摘 | Schwanen T Dijst M Dieleman F | 2004 | Urban Studies2004，41，3： | 1 |
| 8 | Cumulus cell gene expression following the LH surge in bovine preovulatory follicles:potential early markers of oocyte competence 显示文摘 | Assidi M Dieleman SJ Sirard MA | 2010 | Reproduction2010，140，： | 1 |
| 9 | Impact of apre-emptive multimodal analgesia plus femoral nerve blockadeprotocol on rehabilitation, hospital length of stay, and post-operative analgesia after primary total kneearthroplasty: acontrolled clinical pilot study 显示文摘 | Beaupre LA Johnston DB Dieleman S | 2012 | Scientific World J2012，，： | 1 |
| 10 | Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10 deficient mice显示文摘 | SCHULTZ M VELTKAMP C DIELEMAN L A | | 0，，02： | 1 |
| 11 | Inci-dence of facial pain in the general population显示文摘 | 1Koopman JSHA Dieleman JP Huygen FJ | 2009 | Pain2009，147，： | 1 |
| 12 | Adherence to gastropretection and the risk of NSAID - related upper gastrointestinal ulcers and haemorrhage 显示文摘 | Van Soest EM Sturkenboom MC Dieleman JP | 2007 | Aliment Pharmacol Ther2007，26，2： | 1 |
| 13 | Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterizedby Thl and Th2 cytokines 显示文摘 | Dieleman L A Palmen M J | 1998 | Clin Exp Immunol1998，114，3： | 1 |
| 14 | Incidence of facial pain in the general population显示文摘 | Koopman J S Dieleman J P Huygen F J | 2009 | Pain2009，147，13： | 1 |
| 15 | Yield of embryos in PMSG-superovulated cows treated with anti-PMSG six or 18 hours after the peak of luteinis-ing hormone显示文摘 | Bevers M M Dieleman S J Gielen J T | 1993 | Vet Rec1993，132，8： | 1 |
| 16 | Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Thl and Th2 cytokines 显示文摘 | Dieleman LA Palmen MJ Akol H Bloemena E Pena AS Meuwissen SG Van Rees EP | 1998 | Clin Exp Immunol1998，114，： | 1 |
| 17 | Incidence rates and treatment of neuropathic pain conditions in the general population 显示文摘 | Dieleman JP Kerklaan J Huygen FJ | 2008 | Pain2008，137，： | 1 |
| 18 | Cytokinins in rose bybridain relation to bud break显示文摘 | DIELEMAN J A VERSTAPPEN F W Nicand B | 1997 | Physiologia Plantarum1997，99，3： | 1 |
| 19 | Chronic experi- mental colitis induced by dextran sulphate sodium (DSS) is characterized by Thl and Th2 cytokines 显示文摘 | Dieleman LA Pahnen M J Akol H | 1998 | Clin Exp Immunol1998，114，： | 1 |
| 20 | Domperidone and ventricular arrhythmia or sudden cardiac death:a population-based case-control study in the Netherlands显示文摘 | van Noord C Dieleman JP van Herpen G | 2010 | Drug Saf2010，33，11： | 1 |
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