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101篇 您的检索式:作者名="Scherman"
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1Functionalization of Single- and Multi-Walled Carbon Nanotubes with Cationic Amphiphiles for Plasmid DNA Complexation and Transfection显示文摘The possibility of delivering DNA effi ciently to cells represents a crucial issue for the treatment of both genetic and acquired diseases.However,even although the effi ciency of non-viral transfection systems has improved in the last decade,none have yet proven to be suffi ciently effective in vivo.We report herein our results on the functionalization of single-walled carbon nanotubes(SWNT)and multi-walled carbon nanotubes(MWNT)by two cationic amphiphiles(lipid RPR120535 and pyrenyl polyamine),their use for the complexation of plasmid DNA,and their efficiency in transfecting cells in vitro.The experiments have shown that the efficiency of transfection is higher when using SWNT instead of MWNT,and that transfection effi ciency is similar or slightly higher when using nanoplexes(SWNT/lipid RPR120535/DNA)instead of lipoplexes(lipid RPR120535/DNA)and several orders of magnitude higher than that of naked DNA.This study therefore shows both that the transfection is better when using SWNTs and that it is dependent on the nature of the amphiphilic molecules adsorbed on the nanotubes.Cyrille Richard Nathalie Mignet Céline Largeau Virginie Escriou Michel Bessodes Daniel Scherman 2009Nano Research2009,2,8:3
2Unique Mechanism of Action of the Thiourea Drug lsoxyl on Mycobacterium tuberculosis显示文摘Phetsuksiri B Jackson M Scherman H 2003J Biol Chem2003,278,53:1
3Design and evaluation of histidine-rich amphipathic peptides for siR- NA delivery显示文摘Langlet-Bertin B Leborgne C Scherman D 2010Pharm Res2010,27,7:1
4查看详情显示文摘Boussif O Lezoialc'h F Zanta M.A Mergny M.D Scherman D Demeneix B Behr J P 0,,:1
5Electrotransfer into skeletal muscle for protein expression显示文摘Trollet C Bloquel C Scherman D 2006Curr Gene Ther2006,6,5:1
6Polymorphismsat the innate immune receptor TLR2 are associated with Borreliainfection in a wild rodent population显示文摘Tschirren B Andersson M Scherman K 2013Proc Biol Sci2013,280,20:1
7NLS bioconjugates for targeting therapeutic genes to the nucleus显示文摘Virginie Escriou Marie Carrière Daniel Scherman Pierre Wils 2002Advanced Drug Delivery Reviews2002,,2:1
8Neural regeneration along longitudinal polyglactin sutures across short and extend defects in the rat sciatic nerve显示文摘Scherman P Lurdborg G Kanje M 0,,02:1
9Evaluation of nutritional practice in hospitalized cirrhotic patients显示文摘Bernard Campillo Jean-Philippe Richardet Elizabeth Scherman Phuong Nhi Bories 2003Nutrition2003,,6:1
10Anionic pH-sensitive pegylated lipoplexes to deliver DNA to tumors显示文摘Mignet N Richard C Scherman D 2008Int J Pharm2008,361,12:1
11Assessing Quality of Life in Patients with Head and Neck Cancer显示文摘SCHERMAN AC SIMONTON S ADAMS DC 2000Arch Otolaryngol Head Neck Surg(S0886-4470)2000,126,:1
12Assessing quality of life in patients with head and neck cancer 显示文摘Scherman AC Simonton S Adams DC 2000Arch Otolaryngol Head Neck Surg2000,126,:1
13Injectable living marrow stromal cel-based autologous tissue engineered heart valves:first experiences with a one-step intervention in primates显示文摘Weber B Scherman J Emmert MY 0,,22:1
14Development of a quantitative assay for Mycobacterial endogenous arabinase and ensuing studies of arabinase levels and arabinan metabolism in Mycobacterium smegmatis 显示文摘Dong Xu Bhamdi Suresh Scherman Michael 2006Applied and Environmental Microbiology2006,72,4:1
15Drug targeting Mycobacterium tuberculosis cellwall synthesis:genetics of dTDP rhamnose synthetic enzymes and development of a microtiter plate based screen for inhibitors of conversion of dTDP glucose to dTDP rhamnose显示文摘Ma Y Stern RJ Scherman MS 0,,:1
16Factors Influencing Adolescents' Decisions to Engage in Risk - Taking Behavior显示文摘Rolison M R Scherman A 2002Adolescence2002,37,147:1
17Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties 显示文摘North E J Scherman MS Bruhn DF 2013Bioorg Med Chem2013,21,:1
18Assessing quali- ty of life in patients with head and neck cancer 显示文摘Scherman AC Simonton S Adams DC 2000Arch Ototaryngology Head Neck Surg2000,126,:1
19Striatal dopamine deficiency in Parkinson's disease:role of aging显示文摘Scherman D Desnos C Darchen F 1989Ann Neurol1989,26,4:1
20Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis 显示文摘PHETSUKSIRI B JACKSON M SCHERMAN H 2003J Biol Chem2003,278,53:1
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