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| 1 | Urine from patients with transitional - cell carcinoma stimulates migration of capillary endothelial cells 显示文摘 | Chodak G W Scheiner C J Zetter B R | 1981 | N Engl J Meal1981，305，15： | 1 |
| 2 | Root growth and phosphorus uptake in wide and narrow-row soybeans显示文摘 | Scheiner J D Gutierrez-Boom F H Lavado R S | 2000 | Journal of Plant Nutrition2000，23，9： | 1 |
| 3 | Activity of c GMPdependentprotein kinase(PKG)affects sucrose responsiveness and habituation in Drosophila melanogaster显示文摘 | SCHEINER R SOKOLOWSKI M B ERBER J | 2004 | Learn Mem2004，11，3： | 1 |
| 4 | PKG in honey bees:spatial expression,Amfor gene expression,sucrose responsiveness,and division of labor显示文摘 | THAMM M SCHEINER R | 2014 | J Comp Neurol2014，522，8： | 1 |
| 5 | Characterization of the 5HT 1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior显示文摘 | THAMM M BALFANZ S SCHEINER R | 2010 | Cellular and Molecular Life Sciences2010，67，14： | 1 |
| 6 | Behavioural pharmacology of octopamine, tyramine and dopamine in honey bees 显示文摘 | SCHEINER R PLUCKHAHN S | 2002 | Behavioural Brain Research2002，136，： | 1 |
| 7 | Evaluation of endocytoscopy in the surveillance of patients with Barrett’s esophagus显示文摘 | H. Pohl M. Koch A. Khalifa I. Papanikolaou K. Scheiner B. Wiedenmann T. R?sch | 2007 | Endoscopy2007，，06： | 1 |
| 8 | Nitric oxide synthase distribution in the cat superior collieulus and co-localization with choline acetyltransferase 显示文摘 | Scheiner C Arceneaux R Guido W | 2000 | J Chem Neuroanat2000，18，： | 1 |
| 9 | Mobility and Spatial use of the Ground Beetle species Elaphrus cupreus and Elaphrus uligirtosus (Coleoptera: Carabidae) 显示文摘 | Scheiner R Irmler U | 2010 | Entomol Gen2010，32，3： | 1 |
| 10 | Root growth and phosphorus uptake in wide and narrow - low soybeans 显示文摘 | Scheiner J D Gufierrez - Boem F H Lavado R S | 2000 | Journal of Plant Nutrition2000，23，9： | 1 |
| 11 | Effect of Tire Wear on Wear Rate显示文摘 | Brenner F C Scheiner S R Akira K | 1975 | Tire Science and Technology1975，3，4： | 1 |
| 12 | Adaptive phenotypic plasticity:consensus and controversy显示文摘 | Via S Gomulkiewicz R De Jong G Scheiner S.M Schlichting C.D and Van Tienderen P.H | | 0，，： | 1 |
| 13 | Characterization of the 5-HT1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototaetic behavior 显示文摘 | Thamm M Balfanz S Scheiner R | 2010 | Cellular and Molecular Life Sciences2010，67，14： | 1 |
| 14 | Cognitive aging is linked to social role in honey bees (Ap~ meZl- ifera) 显示文摘 | BEHRENDS A SCHEINER R BAKER N | 2007 | Exp Gerontol2007，42，： | 1 |
| 15 | The role of nitric oxide in development of the patch-cluster system and retinocollicular pathways in the rodent superior colliculus显示文摘 | Mize RR Wu HH Cork R J Scheiner CA | | 0，，： | 1 |
| 16 | Impaired tactile learning is related to social role in honeybees 显示文摘 | SCHEINER R AMDAM G V | 2009 | J Exp Biol2009，212，： | 1 |
| 17 | Root growth and phosphorus uptake in wide and narrow-row soybeans显示文摘 | Scheiner J D Gutierrez-Boem F H Lavado R S | 2000 | Journal of Plant Nutrition2000，23，9： | 1 |
| 18 | Mobility and Spatial use of the Ground Beetle species Elaphrus cupreus and Elaphrus uliginosus (Coleoptera: Carabidae) 显示文摘 | Scheiner R Irmler U | 2010 | Entomologia Generalis2010，32，3： | 1 |
| 19 | Root growth and phosphorus uptake in wide and narrow row soybeans 显示文摘 | Scheiner J D Gutierrez-Boem F H Lavado R S | 2003 | Journal of plant Nutrition2003，23，9： | 1 |
| 20 | Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma显示文摘BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs. | Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U Marron Anwaar Saeed Yi-Hsiang Huang Mahvish Muzaffar Matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani Musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida Yehia Ibrahim Mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter R Galle Anjana Pillai Ying-Hong Wan Alessio Cortellini Masatoshi Kudo Antonio D’Alessio Lorenza Rimassa David James Pinato Celina Ang | 2023 | World Journal of Gastrointestinal Oncology2023，15，11： | 0 |
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