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| 1 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 2 | Peptide transport by the multidrug resistance protein MRP1 显示文摘 | de Jong M C Slootstra J W Scheffer G L | 2001 | Cancer Res2001，61，6： | 1 |
| 3 | Abnormal corneal ep- ithelial wound healing inpartial-thichness removal of lim- bal epithelium 显示文摘 | JAMES J Y C SCHEFFER C G T | 1991 | Invest Ophthalmol Vis Sci1991，32，1： | 1 |
| 4 | The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines 显示文摘 | SCHROEIJERS A B SIVA A C SCHEFFER G L | 2000 | Cancer Res2000，60，4： | 1 |
| 5 | Right ventricular outflow and apical pacing comparably worsen the echocardiographic normal left ventricle显示文摘 | TEN C T SCHEFFER M G SUTHERLAND G R | 2008 | Eur J Echocardiogr2008，9，： | 1 |
| 6 | The Solubility of naphthalene in supercritical ethylene 显示文摘 | Diepen G A M Scheffer F E C | 1948 | JACS1948，70，12： | 1 |
| 7 | Induced nitric oxide impairs relaxation but not contraction in endotoxinexposed rat pulmonary arteries 显示文摘 | Boer C Groeneveld A B Scheffer G J | 2005 | J Surg Res2005，127，2： | 1 |
| 8 | Decolorizing and detoxifying textile wastewater,containing both soluble and insoluble dyes,in a full scale combined anaerobic/ aerobic system显示文摘 | Frijters C T M J Vos R H Scheffer G | 2006 | Water Res2006，40，6： | 1 |
| 9 | Decolorizing and detoxifying textile wastewater, containing both soluble and insoluble dyes, in a full scale combined anaerobic/ aerobic system 显示文摘 | Ftijters C T Vos R H Scheffer G | 2006 | Water Research2006，40，： | 1 |
| 10 | Conjunctivochalasis:Literature Review and possible pathophsiology显示文摘 | Dniel meller Scheffer C G Tseng | 1998 | Survey of phthalmology1998，43，3： | 1 |
| 11 | Conjunctivochala- sis: Literature Review and possible pathophsiology 显示文摘 | Dniel meller Scheffer C G Tseng | 1998 | Survey of phthalmology1998，43，3： | 1 |
| 12 | Multidrug resistance related molecules in human and murine lung 显示文摘 | SCHEFFER G L PIJNENBORG A C SMITE F | 2002 | J Clin Pathol2002，55，5： | 1 |
| 13 | Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier显示文摘 | WIJNHOLDS J DE LANGE E C SCHEFFER G L | 2000 | J Clin Invest2000，105，3： | 1 |
| 14 | Comparison of experimen- tal chest compression data to a theoretical model for the mechanics of constant peak displacement cardiopulmonary resus- citation显示文摘 | Cloete G Dellimore KH Scheffer C | 2011 | AcadEmergMed2011，18，11： | 1 |
| 15 | Amniotic membrane transplantation for persistent corneal epithelial defence显示文摘 | Scheffer C Tseng G | 2001 | Br J Ophthalmol2001，85，5： | 1 |
| 16 | 查看详情显示文摘 | Gnaccarini C Peter S Scheffer U Vonhoff S Klussmann S G?bel M W | | 0，，： | 1 |
| 17 | Contribution of the FtsQ transmembrane segment to localization to the cell division site显示文摘 | Scheffers D J Robichon C Haan G J | 2007 | Journal of Bacteriology2007，189，20： | 1 |
| 18 | Conjuctivochalasis: literature review and possible pathophysiology 显示文摘 | Meller D Scheffer C Tseng G | 1998 | Survey of Ophthalmology1998，43，3： | 1 |
| 19 | Decolorizingand detoxifying textile wastewater,containing oth solubleand insoluble dyes,in a full scale combined anaerobic/aerobic system显示文摘 | Frijters C T Vos R H Scheffer G | 2006 | Water Res2006，40，6： | 1 |
| 20 | Decolorizing and detoxifying textile wastewater, containing both soluble and insoluble dyes, in a full scale combined anaerobic/aerobic system显示文摘 | Ftijters C T M J Vos R H Scheffer G | 2006 | Water Research2006，40，： | 1 |
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