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	题名	作者	年代	出处	被引量
1	Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery.	Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen	2008	World Journal of Gastroenterology2008，14，45：	4
2	Peptide transport by the multidrug resistance protein MRP1 显示文摘	de Jong M C Slootstra J W Scheffer G L	2001	Cancer Res2001，61，6：	1
3	Cytokines and biotrauma in ventilator - induced lung injury : a critical review of the literature显示文摘	Halbertsma F J Vanekker M Scheffer G J	2005	Neth J Med2005，63，10：	1
4	Associations of metabolic variables with arterial stiffness in type 2 diabeies mellitus: focus on insulin sensitivity and postprandial triglyceridaemia显示文摘	van Dijk R A Bakker S J Scheffer P G	2003	Eur J Clin Invest2003，33，4：	1
5	Importance of nutrient competition and allelopathic effects in suppression of the green alga Scenedesmus obliquus by the macrophytes Chara,Elodea and Myriophyllum 显示文摘	Lurling M Geest G V Scheffer M	2006	Hydrobiologia2006，556，1：	1
6	Best Practice Guidelines for Molecular Analysis in Spinal Muscular Atrophy显示文摘	Scheffer H Cobben J M Matthijs G	2001	European Journal of Human Genetics2001，9，7：	1
7	Bacterial cell wall synthesis: newinsights from localization studies 显示文摘	Scheffers D J Pinho M G	2005	Microbiol Mol Biol Rev2005，69，4：	1
8	Abnormal corneal ep- ithelial wound healing inpartial-thichness removal of lim- bal epithelium 显示文摘	JAMES J Y C SCHEFFER C G T	1991	Invest Ophthalmol Vis Sci1991，32，1：	1
9	No effect of atorvastatin and simvastatin on oxidative stress in patients at high risk for cardiovascular disease显示文摘	SCHEFFER P G SCHINDHELM R K VAN VERS-CHUER V M	2013	Neth J Med2013，71，：	1
10	A prospective randomised controlled trial of ultrasound guided versus nerve stimulation guided distal sciatic nerve block at the popliteal fossa显示文摘	van Geffen G J van den Broek E Braak G J J Giele J L P Gielen M J Scheffer G J	2009	Anaesthesia and Intensive Care2009，，：	1
11	The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines 显示文摘	SCHROEIJERS A B SIVA A C SCHEFFER G L	2000	Cancer Res2000，60，4：	1
12	A consensus statement on critical thinking in nursing显示文摘	Scheffer B K Ruhenfeld M G	2000	J Nurs Educ2000，39，8：	1
13	Right ventricular outflow and outflow and apical pacing comparably worsen the echocardiographic normal left ventricle 显示文摘	TEN CATE T J SCHEFFER M G SUTHERLANG G R	2008	Eur Echocargiogr2008，9，5：	1
14	Cytokines and biotrauma in ventilator-induced lung injury:a critical review of the literature显示文摘	HALBERTSMA F J VANEKER M SCHEFFER G J	2005	Neth J Med2005，63，10：	1
15	Right ventricular outflow and apical pacing comparably worsen the echocardiographic normal left ventricle显示文摘	TEN C T SCHEFFER M G SUTHERLAND G R	2008	Eur J Echocardiogr2008，9，：	1
16	The drug resistance- related protein LRP is the human major vault protein 显示文摘	Scheffer G L wijngaard P L Flens M J	1995	Nat Med1995，1，6：	1
17	Analysis of expression of eMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance associated protein gene (MRP1) in human cancer cell lines显示文摘	Kool M de Haas M Scheffer G L	1997	Cancer Res1997，57，：	1
18	Critical thinking: A tool in search of a job显示文摘	Scheffer B K Rubenfeld M G	2006	J Nurs Educ2006，45，6：	1
19	Drug resistance molecules: lessons from oncology显示文摘	Scheper R J	2002	Novartis Found Symp2002，243，：	1
20	Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy显示文摘	Leggas M Adachi M Scheffer G L	2004	Molecular and Cellular Biology2004，24，17：	1

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