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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Hepatic 31P magnetic resonance spectroscopy:a hepatologist's user guide(Review)显示文摘 | Solga SF Horska A Clark JM | 2005 | Liver Int2005，25，3： | 1 |
| 3 | Cloning,ex-pressing,prification and functional characterizationof the oligomerization domain of Bcr-Abl oncopro-tein fused to the cytoplasmic transduction peptide显示文摘 | Huang SF Liu DB Zeng JM | 2009 | Protein Expr Purif2009，64，2： | 1 |
| 4 | Oral and dental manifestations in diabetic and nondiabetic uremic patients receiving hemodialysis显示文摘 | Sung JM Kuo SC | 2005 | Oral Surg Oral Med Oral Pathol Oral Redid Endod2005，99，6： | 1 |
| 5 | Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo显示文摘 | Previs SF Withers DJ Ren JM | 2000 | J Biol Chem2000，275，38： | 1 |
| 6 | Low-dose tryptophan depletion in recovered depressed women induces impair merits in autobiographical memory specificity显示文摘 | Haddad AD Williams JM McTavish SF | 2009 | Psychopharmacology (Berl)2009，207，3： | 1 |
| 7 | TAT transduction:the molecular mechanism and therapeutic prospects显示文摘 | Gump JM Dowdy SF | 2007 | Trends Mol Med2007，13，10： | 1 |
| 8 | Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens显示文摘 | SF Chin Liu W JM Storkson | 1992 | Food Composition and Analysis1992，，5： | 1 |
| 9 | Quantification of DNA in biologic scaffold materials显示文摘 | Gilbert TW Freund JM Badylak SF | | 0，，： | 1 |
| 10 | Conjugated inoleic acid is a growth factor for rats as shown by enhanced weight gain and im proved feed efficiency 显示文摘 | Chin SF Storkson JM Abright KJ | 1994 | J Nutr1994，124，： | 1 |
| 11 | TAT transduction: the molecular mechanism and therapeutic prospects 显示文摘 | Gump JM Dowdy SF | 2007 | Trends Mol Med2007，13，10： | 1 |
| 12 | Anticoagulation for cerebral venous sinus thrombosis 显示文摘 | Coutinho JM De Bruijn SF Deveber G | 2012 | Stroke2012，43，4： | 1 |
| 13 | Race and comorbid factors predict nonalcoholic fatty liver disease histopathology in severely obese patients显示文摘 | Solga SF Clark JM Alkhuraishi AR | 2010 | Surg Obe s Relat Dis2010，1，： | 1 |
| 14 | Per2 inhibits k562leukemia cell growth in vitro and in vivo through cell cycle ar-rest and apoptosis induction显示文摘 | Sun CM Huang SF Zeng JM | 2010 | Pathol Oncol Res2010，16，3： | 1 |
| 15 | Biocompatibility of a new semi-solid bioerodible poly (ortho ester) intended for ocular delivery of 5-fluorouracil显示文摘 | Bernatchez SF Merkli A Minh TL Tabatabay C Anderson JM Gurny R | 1994 | J Biomed Mater Res1994，28，9： | 1 |
| 16 | Determination of alpha - fetoprotein in human serum by a Quartz Crystal Microbalance-based Immunosensor显示文摘 | Chou SF Hsu WL Hwang JM | 2002 | Clin Chem2002，48，： | 1 |
| 17 | Arterio arterial vascular anastomoses in monochorionie placentas with and without twin twin transfusion syndrome显示文摘 | de Villiers SF Slaghekke F Middeldorp JM | 2012 | Placenta2012，33，8： | 1 |
| 18 | The effect of a probiotic on hepatic steatosis 显示文摘 | Solga SF Buckley G Clark JM Horska A Diehl AM | 2008 | J Clin Gastroenterol2008，42，10： | 1 |
| 19 | Arterio-arterial vascular anastomoses in monochorionic placentas with andwithout twin-twin transfusion syndrome 显示文摘 | de Villiers SF Slaghekke F Middeldorp JM | 2012 | Placenta2012，33，8： | 1 |
| 20 | Dynamics of hepatitis B virus clearance in chimpanzees 显示文摘 | Murray JM Wieland SF Purcell RH | 2005 | Proe Natl Acad Sci USA2005，102，17： | 1 |
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