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| 1 | 脊髓神经干细胞的培养和鉴定显示文摘目的 研究脊髓源性神经干细胞的培养和体外分化情况 .方法 采用细胞培养技术结合间接免疫荧光细胞化学法 .结果 1在只有 EGF存在的情况下 ,没有干细胞团的生成 ;而在只有 b FGF存在的情况下 ,有少量干细胞团生成 ;在EGF和 b FGF同时存在时 ,有大量神经干细胞团生成 . 2体外存活时间越长 ,培养中的干细胞成分越多 ,分化后成分越少 . 3随诱导分化时间的加长 ,分化的细胞类型开始出现并增多 ,干细胞比率下降 .结论 脊髓神经干细胞的存活有赖于 EGF和 b FGF的共同作用 ,体外培养 4wk以上的细胞 ,所含的前体细胞的成分较少 。 | 孟晋宏 Udo Bartsch Melitta Schachner 鞠躬 | 2000 | 第四军医大学学报2000，21，8： | 20 |
| 2 | A Surgery Protocol for Adult Zebrafish Spinal Cord Injury显示文摘成年 zebrafish 有一个显著能力从针的绳索损害恢复,提供为学习 neuroregeneration 的一个优秀模型。这里,我们列出设备和试剂,并且为成年 zebrafish 的完全的横断给一个详细协议针的绳索。在这个协议,潜在的问题和他们的答案被描述以便 zebrafish 针的绳索损害模型能更容易并且 reproducibly 被执行。另外,二个评价被介绍监视外科和功能的恢复的成功:估计免费游泳能力的一测试和另外的测试到估计 neuroregeneration 的程度由在跟踪的 vivo anterograde axonal。在游泳行为测试,成功的完全的针的绳索横断被 zebrafish 的无能监视在针的绳索损害以后自由地游泳 1 个星期,在损害以后在 6 个星期以内由全部的运动能力的渐渐的获得列在后面。作为 morphometric 相互关联,跟踪的 anterograde axonal 允许调查者监视改革轴突的能力穿过损害地点并且逐渐地在损害以后与时间延续到灰色、白的事,证实功能的恢复。这个 zebrafish 模型从针的绳索损害为恢复提供一个范例,启用小径的鉴定和 neuroregeneration 的部件。 | Ping Fang Jin-Fei Lin Hong-Chao Pan Yan-Qin Shen Melitta Schachner | 2012 | Journal of Genetics and Genomics2012，39，9： | 7 |
| 3 | A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis显示文摘Oxidative stress contributes to the pathogenesis of neurodegenerative diseases.With the aim to find reagents that reduce oxidative stress,a phage display library was screened for peptides mimicking a2,6-sialyllactose(6'-SL),which is known to beneficially influence neural functions.Using Sambucus nigra lectin,which specifically binds to 6'-SL,we screened a phage display library and found a peptide comprising identical sequences of 12 amino acids.Mimetic peptide,reverse peptide and scrambled peptide were tested for inhibition of 6'-SL binding to the lectin.Indeed,lectin binding to 6'-SL was inhibited by the most frequently identified mimetic peptide,but not by the reverse or scrambled peptides,showing that this peptide mimics 6'-SL.Functionally,mimetic peptide,but not the reverse or scrambled peptides,increased viability and expression of neural cell adhesion molecule L1 in SK-N-SH human neuroblastoma cells,and promoted survival and neurite outgrowth of cultured mouse cerebellar granule neurons challenged by H_20_2-induced oxidative stress.The combined results indicate that the 6'-SL mimetic peptide promotes neuronal survival and neuritogenesis,thus raising hopes for the treatment of neurodegenerative diseases.This study was approved by the Medical Ethics Committee of Shantou University Medical College,China(approval No.SUMC 2014-004)on February 20,2014. | Shuang-Xi Chen Jia-Hui He Yong-Jian Mi Hui-Fan Shen Melitta Schachner Wei-Jiang Zhao | 2020 | Neural Regeneration Research2020，15，6： | 2 |
| 4 | Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvo- momlin, laminin, fibronectin, and a heparan sulfate proteo- glycan) in embryonic, adult, and denervated adult skeletal muscle显示文摘 | Sanes JR Schachner M Covault J | 1986 | J Cen Biol1986，102，2： | 1 |
| 5 | 'Mid-G'Re-gion sequences of the glycoprotein gene of Austrian infectious hematopoi-etic necrosis virus isolates form two lineages within European isolates andare distinct from American and Asian lineages显示文摘 | KOLODZIEJEK J SCHACHNER O DRRWALD R | 2008 | J Clin Microbiol2008，46，1： | 1 |
| 6 | Risk factors for late stroke after coronary artery bypass grafting显示文摘 | Schachner T Zimmer A Nagele G | 2005 | J Thorac Cardio- vasc Surg2005，130，2： | 1 |
| 7 | Giant aplasia cutis congenita without associated anomalies显示文摘 | Benjamin LT Trowers AB Schachner LA | 2004 | Pediatr Dermatol2004，21，2： | 1 |
| 8 | Effectiveness and safety of total endoscopic left internal mammary artery bypass graft to the left anterior descending artery显示文摘 | Bonatti J Schachner T Bonaros N | 2009 | Am J Cardiol2009，104，12： | 1 |
| 9 | Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state:role of reactive oxygen species (ROS),eNOS,and heme oxygenase (HO-1) levels显示文摘 | Heiss EH Schachner D Wemer ER Dirsch VM | | 0，，46： | 1 |
| 10 | One hour electrical stimulation accelerates functional recovery after femoral nerve repair 显示文摘 | Ahlborn P Schachner M Irintchev A | 2007 | Exp Neurol2007，208，1： | 1 |
| 11 | HMGB1 in development and diseases of the central nervous system显示文摘 | Fang P Schachner M Shen YQ | 2012 | Mol Neurobiol2012，45，3： | 1 |
| 12 | Perivaacular application of C-type natriuretic peptide attenuates neointimal hyperpla-sin in experimental vein grafts显示文摘 | Schachner T Zou Y | 2004 | Eur J Cardiothorac Surg2004，，25： | 1 |
| 13 | Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status显示文摘 | Ladurner A Schmitt CA Schachner D | 2012 | Free Radic Biol Med2012，52，10： | 1 |
| 14 | Abnormal renalphenotype in L1 knockout mice: a novel cause of CAKUT 显示文摘 | Debiec H Kutsche M Schachner M | 2002 | Nephrol Dial Transplant2002，17，9： | 1 |
| 15 | Robotically assisted totally endoscopic atrial septal defect repair: insights from operative times, learning curves, and clinical outcome 显示文摘 | Bonaros N Schachner T Oehlinger A | 2006 | Ann Thorac Surg2006，82，2： | 1 |
| 16 | Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin显示文摘 | Schachner M Bartsch U | 2000 | Glia2000，29，2： | 1 |
| 17 | Synthetic cryptolepine inhibits DNA binding of NF-kappaB 显示文摘 | OLAJIDE O A HEISS E H SCHACHNER D | 2007 | Bioorg Med Chem2007，15，1： | 1 |
| 18 | Neural recognition molecules of the immunoglobulin superfamily : signaling transducers of axon guidance and neuronal migration显示文摘 | Maness PF Schachner M | 2007 | Nat Neurosci2007，10，1： | 1 |
| 19 | Quality of life improvement after robotically assisted coronary artery bypass grafting显示文摘 | Bonaros N Schachner T Wiedemann D | 2009 | Cardiology2009，114，1： | 1 |
| 20 | Tenascin-C expression and axonal sprouting following injury to the spinal dorsal columns in the adult rat显示文摘 | Zhang Y Winterbottom J K Schachner M | 1998 | J Neurosci Res1998，49，4： | 1 |
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