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| 1 | Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies显示文摘Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast Asia.Although T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at diagnosis.In fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam radiotherapy.This treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy alone.Several trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or chemo-radiotherapy.Platinum compounds,anthracyclines and taxanes are among the chemotherapy agents employed.This review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach. | Francesco Perri Davide Bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati | 2011 | World Journal of Clinical Oncology2011，2，12： | 24 |
| 2 | Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas显示文摘AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined. | Francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Longo Paolo Muto Concetta Schiavone Fabio Sandomenico Francesco Caponigro | 2013 | World Journal of Clinical Oncology2013，4，2： | 22 |
| 3 | Optimal management of a patient with recurrent nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma is rare in western countries, accounting for less than 1% of all malignancies. Despite prognosis is satisfactory for newly diagnosed, non-metastatic disease, management of recurrent disease is challenging, with a survival expectancy of approximately 6 mo with the use of chemotherapy as the sole salvage treatment. We report a case of recurrent nasopharyngeal carcinoma treated with a combination of chemotherapy, radiotherapy and surgery in the context of a multidisciplinary approach. A durable complete response was achieved. | Francesco Perri Italo Dell’Oca Paolo Muto Concetta Schiavone Corrado Aversa Franco Fulciniti Raffaele Solla Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Caponigro | 2014 | World Journal of Clinical Cases2014，2，7： | 8 |
| 4 | Anaplastic thyroid carcinoma:A comprehensive review of current and future therapeutic options显示文摘Anaplastic thyroid carcinoma(ATC)is the rarest,but deadliest histologic type among thyroid malignancies,with a dismal median survival of 3-9 mo.Even though ATC accounts for less than 2%of all thyroid tumors,it is responsible for 14%-39%of thyroid carcinoma-related deaths.ATC clinically presents as a rapidly growing mass in the neck,associated with dyspnoea,dysphagia and vocal cord paralysis.It is usually locally advanced and often metastatic at initial presentation.For operable diseases,the combination of radical surgery with adjuvant radiotherapy or chemotherapy,using agents such as doxorubicin and cisplatin,is the best treatment strategy.Cytotoxic drugs for advanced/metastatic ATC are poorly effective.On the other hand,targeted agents might represent a viable therapeutic option.Axitinib,combretastatin A4,sorafenib and imatinib have been tested in small clinical trials of ATC,with a promising disease control rate ranging from 33%to 75%.Other clinical trials of targeted therapy for thyroid carcinoma are currently ongoing.Biological agents that are under investigation include pazopanib,gefitinib and everolimus.With the very limited therapeutic armamentarium available at the present time,targeted therapy constitutes an exciting new horizon for ATC.In future,biological agents will probably represent the standard of care for this aggressive malignancy,in the same fashion as it has recently occurred for other chemo-refractory tumors,such as kidney and hepatic cancer. | Francesco Perri Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Carlo Buonerba | 2011 | World Journal of Clinical Oncology2011，2，3： | 5 |
| 5 | Isolamento e costituzione dell acido rosmarinico显示文摘 | SCARPATI M L ORIENTE G | 1958 | Ric Sci1958，28，： | 1 |
| 6 | Thrombin antithrom- bin complex and IL-18 serum levels in stroke patients 显示文摘 | Piazza O Scarpati G Cotena S | 2010 | Neurol Int2010，2，1： | 1 |
| 7 | Hyperbolic trajectories for pick-and-operations to elude obstacles显示文摘 | Muller-karger C M Granaries Mirena A L Scarpati lopez J T | 2000 | IEEE Transactions and automation2000，，3： | 1 |
| 8 | Terlipressin in brain-death donors显示文摘 | Piazza O Scarpati G Rispoli F | 2012 | Clin Transplant2012，2，12： | 1 |
| 9 | Update on transfusion solutions during surgery: review of hydroxyethyl starches 130/0.4显示文摘 | Ornella Piazza Giuliana Scarpati | 2010 | International Journal of General Medicine . 2010 (defa)2010，，： | 1 |
| 10 | Effect of cytomegalovirusimmediate early gene produces on endothelial cell gene activity显示文摘 | Guetta E Scarpati EM Dicorleto PE | 2001 | Cardiovasc Res2001，50，3： | 1 |
| 11 | A spe- cific miRNA signature correlates with complete pathological re- sponse to neoadjuvant chemoradiotherapy in locally advanced rec- tal cancer显示文摘 | Della Vittoria Scarpati G Falcetta F Carlomagno C | 2012 | Int J Radiation Oncol Biol Phys2012，83，4： | 1 |
| 12 | A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer显示文摘 | Vittoria D Scarpati G Falcetta F | 2012 | Int J Radiat Oncol Biol2012，83，4： | 1 |
| 13 | Thrombin antithrom- bin complex and IL-18 serum levels in stroke patients 显示文摘 | Piazza O Scarpati G Cotena S | 2010 | Neurol Int2010，2，1： | 1 |
| 14 | A specific miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer显示文摘 | Della Vittoria Scarpati G Falcetta F Carlomagno C | 2012 | Int J Radiat Oncol Biol Phys2012，83，4： | 1 |
| 15 | Ipilimumab in the treatment of metastatic melanoma: management of adverse events显示文摘 | Delia Vittoria Scarpati G Fusciello C Perri F | 2014 | Onco Targets Ther2014，7，： | 1 |
| 16 | Chlorogenic acid : Further evidence for its antigenic and allergenic activity显示文摘 | DS Bariana J Krupey L M Scarpati | 1965 | Nature1965，207，2： | 1 |
| 17 | A Specific miRNA Signature Correlates With Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer显示文摘 | Giuseppina Della Vittoria Scarpati Francesca Falcetta Chiara Carlomagno Paolo Ubezio Sergio Marchini Alfonso De Stefano Vijay Kumar Singh Maurizio D’Incalci Sabino De Placido Stefano Pepe | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 18 | Effect of cytomegalovirus immediate early gene products on endothelial cell gene activity 显示文摘 | Guetta E Scarpati EM DiCorleto PE | 2001 | Cardiovasc Res2001，50，3： | 1 |
| 19 | Epstein-Barr virus in- fection and nasopharyngeal carcinoma: the other side of the coin 显示文摘 | Perri F Scarpati GDV Giuliano M | 2015 | Anti-cancer drugs2015，26，10： | 1 |
| 20 | A specif- ic miRNA signature correlates with complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer 显示文摘 | Della Vittoria Scarpati G Falcetta F Carlomagno C | 2012 | Int J Radiat Oncol Biol Phys2012，83，： | 1 |
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