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| 1 | Early diabetic neuropathy:Triggers and mechanisms显示文摘Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the most frequent and troublesome complications of diabetes mellitus. It is the major reason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presenta- tions of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glu- cose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has ac- cumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, cor- relation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our un- derstanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on clinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia. | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | World Journal of Gastroenterology2007，13，2： | 55 |
| 2 | Distribution and changes of active layer thickness(ALT) and soil temperature(TTOP) in the source area of the Yellow River using the GIPL model显示文摘Active layer thickness(ALT) is critical to the understanding of the surface energy balance, hydrological cycles, plant growth, and cold region engineering projects in permafrost regions. The temperature at the bottom of the active layer, a boundary layer between the equilibrium thermal state(in permafrost below) and transient thermal state(in the atmosphere and surface canopies above), is an important parameter to reflect the existence and thermal stability of permafrost. In this study, the Geophysical Institute Permafrost Model(GIPL) was used to model the spatial distribution of and changes in ALT and soil temperature in the Source Area of the Yellow River(SAYR), where continuous, discontinuous, and sporadic permafrost coexists with seasonally frozen ground. Monthly air temperatures downscaled from the CRU TS3.0 datasets, monthly snow depth derived from the passive microwave remote-sensing data SMMR and SSM/I, and vegetation patterns and soil properties at scale of 1:1000000 were used as input data after modified with GIS techniques. The model validation was carried out carefully with in-situ ALT in the SAYR interpolated from the field-measured soil temperature data. The results of the model indicate that the average ALT in the SAYR has significantly increased from 1.8 m in 1980 to 2.4 m in 2006 at an average rate of 2.2 cm yr–1. The mean annual temperature at the bottom of the active layer, or temperature at the top of permafrost(TTOP) rose substantially from –1.1℃ in 1980 to –0.6℃ in 2006 at an average rate of 0.018℃ yr–1. The increasing rate of the ALT and TTOP has accelerated since 2000. Regional warming and degradation of permafrost has also occurred, and the changes in the areal extent of regions with a sub-zero TTOP shrank from 2.4×104 to 2.2×104 km2 at an average rate of 74 km2 yr–1. Changes of ALT and temperature have adversely affected the environmental stability in the SAYR. | LUO DongLiang JIN HuiJun Sergei MARCHENKO Vladimir ROMANOVSKY | 2014 | Science China Earth Sciences2014，57，8： | 14 |
| 3 | Controversies in fluid therapy: Type, dose and toxicity显示文摘Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ‘‘crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity(fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy basedon functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity(fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ‘‘default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients. | Robert C McDermid Karthik Raghunathan Adam Romanovsky Andrew D Shaw Sean M Bagshaw | 2014 | World Journal of Critical Care Medicine2014，3，1： | 5 |
| 4 | CENTERS OF SOME CUBIC SYSTEMS显示文摘We solve the l:-l resonant center problem for two cubic systems with complex coefficients. | Valery G. ROMANOVSKI (Center for Applied Math. and Theoretical Physics, University of Maribor, Krekova 2, SI-2000 Maribor, Slovenia) and (Belarusian State University of Informatics & Radioelectronics, P.Brovka 6 Minsk 220027 Belarus) Alexandru ■UB■ (Dep | 2001 | Annals of Differential Equations2001，17，4： | 2 |
| 5 | 早期糖尿病神经病变:病因与机制显示文摘外周神经病变,尤其是末梢神经病变,是糖尿病最常见而棘手的并发症之一。它是糖尿病患者发病与死亡的主要原因,还常与衰弱性疼痛相关。遗憾的是,我们对糖尿病末梢神经病变自然史与发病机理的了解仍然有限。本文介绍2007年1月《World J Gastroenterol》杂志上有关该病的早期病因与机制。 | Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers | 2007 | 继续医学教育2007，21，5： | 1 |
| 6 | Evidence for Warming and Thawing of Discontinuous Permafrost in Alaska 显示文摘 | Osterkamp T E Romanovsky V E | 1999 | Permafrost and Periglacial Processes1999，10，1： | 1 |
| 7 | Past and recent changes in air and permafrost temperatures in eastern Siberia显示文摘 | Romanovsky V E Sazonova T S Balobaev V T | 2007 | Global and Planetary Change2007，56，34： | 1 |
| 8 | Global climate model performance over Alaska and Greenland显示文摘 | Walsh J E Chapman W L Romanovsky V | 2008 | J Climate2008，21，： | 1 |
| 9 | Evidence for warmingand thawing of discontinuous permafrost in Alaska显示文摘 | Osterkamp T E Romanovsky V E | 1999 | Per- mafrost and Periglacial Processes1999，10，： | 1 |
| 10 | The role of snow cover in the warming of arctic permafrost显示文摘 | Stieglitz M Dery S Romanovsky V | 2003 | Geophysical Research Letters2003，30，13： | 1 |
| 11 | Estimation of soil thermal properties using in-situ temperature measurements in the active layer and permafrost显示文摘 | Nicolsky D J Romanovsky V E Panteleev G G | 2009 | Cold Regions Science and Technology2009，55，1： | 1 |
| 12 | A Comparative Study of Exception Handling Mechanism for Building Dependable Object-Oriented Software显示文摘 | Garcia A Rubira C Romanovsky A | 2001 | The Journal of Systems and Software2001，59，2： | 1 |
| 13 | Perma- frost warming in the Tienshan Mountains, Central Asia显示文摘 | Marehenko S S Gorbunov A P Romanovsky V E | 2007 | Global and Planetary Change2007，56，： | 1 |
| 14 | The integrability conditions for two cubic vector fields显示文摘 | ROMANOVSKI V G SHCHEGLOVA N L | 2000 | Differential Equations2000，36，1： | 1 |
| 15 | Incorporation of a permafrost model into a large-scale ecosystem model:Evaluation of temporal and spatial scaling issues in simulating soil thermal dynamics显示文摘 | Zhuang Q Romanovsky V E McGuire A D | 2001 | J Geophys Res2001，106，33： | 1 |
| 16 | Estimation of soil thermal properties using in-situ temperature measurements in the active layer and permafrost显示文摘 | NICOLSKY D J ROMANOVSKY V E PANTELEEV G G | 2009 | Cold Regions Science and Technology2009，55，1： | 1 |
| 17 | Integrability conditions for Lotka-Voherra planar complex quintic systems显示文摘 | GINIE J ROMANOVSKI V G | 2010 | Nonlinear Analysis: Real World Applications2010，11，3： | 1 |
| 18 | Integrability conditions for complex systems with homogeneous quintie nonlinearities显示文摘 | FERCEC B CHEN X W ROMANOVSKI V G | 2011 | Journal of Applied Analysis and Computation2011，1，1： | 1 |
| 19 | Faulty version recovery in object-oriented N-version programming 显示文摘 | Romanovsky A | 2000 | IEE Proceedings: Software2000，147，3： | 1 |
| 20 | Selected contribution:ambient temperature for experiments in rats:a new method for determining the zone of thermal neutrality显示文摘 | Romanovsky AA Ivanov AI Shimansky YP | 2002 | J Appl Physiol2002，92，6： | 1 |
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