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| 1 | Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis显示文摘AIM:To study serum levels of leptin and adiponectin in patients with chronic hepatitis C virus infection genotype-4(HCV-4) related steatosis and fibrosis.METHODS:We prospectively studied 45 untreated men with chronic HCV-4,with proven steatosis(group Ⅰ,30 patients),and fibrosis(group Ⅱ,15 patients),on liver biopsy.In addition,15 healthy men(group Ⅲ),matched for age,and body mass index were included.However,we excluded another five patients with steatohepatitis,and six patients with cirrhosis.We measured total serum leptin and adiponectin levels,as potential predictors for liver steatosis and fibrosis.Also,a correlation between these adipokines and various clinical and laboratory data were evaluated.All subjects were selected from Tropical and Internal medicine departments,Menoufiya University Hospital,Menoufiya,Egypt,during the period from February 2010 to August 2011.RESULTS:In group Ⅰ,severity of hepatic steatosis was mild,moderate,and severe,in 19 patients(63.5%),8 patients(26.5%),and 3 patients(10%),respectively.In contrast,in group Ⅱ,hepatic fibrosis was found to be in stage 1,2,and 3,in 6 patients(40%),in 6 patients(40%),and in 3 patients(20%),respectively.On comparing group Ⅰ with group Ⅱ,there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 436 ± 9.75 pg/mL,P < 0.001),while there was no significant difference between both groups regarding serum leptin levels(34.69 ± 7.69 ng/mL vs 35.17 ± 1.06 ng/mL,P > 0.05).However,in the same group,when compared with group Ⅲ,there was a significant increase in serum leptin levels(34.69 ± 7.69 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001),while there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 342.4 ± 44.48 pg/mL,P < 0.001).In contrast,in group Ⅱ,when compared with group Ⅲ,there was a significant increase in serum leptin and adiponectin levels(35.17 ± 1.06 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001,and 436 ± 9.75 pg /mL vs 342.4 ± 44.48 pg/mL,P < 0.05,respectively),while there was no significant difference between both groups regarding serum creatinine(0.83 ± 0.34 vs 0.89 ± 0.24,P > 0.05).On the other hand,serum leptin was not correlated with serum adiponectin in group Ⅰ and in group Ⅱ(r = 0.09,P > 0.05,and r =-0.1,P > 0.05,respectively).However,serum adiponectin was significantly negatively correlated with serum aspartate transaminase in group Ⅰ,but no correlation detected in group Ⅱ(r =-0.39,P > 0.05,and r =-0.03,P > 0.05).CONCLUSION:In male patients with chronic HCV-4,serum adiponectin levels are elevated in hepatic fibrosis,but decreased in steatosis.Therefore,in contrast to leptin,adiponectin may be used as a non-invasive marker. | Tarek E Korah Sawsan El-Sayed Maathir K ElShafie Ghada E Hammoda Manal A Safan | 2013 | World Journal of Hepatology2013，5，2： | 7 |
| 2 | Association of gene variants with susceptibility to type 2 diabetes among Omanis显示文摘AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among Omanis.METHODS:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,Oman.Adult control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical checkup.The difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this study.Almost all volunteers questioned had a relativewith diabetes mellitus.Inspite of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%power.Data was collected from June 2010 to February 2012.RESULTS:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an association of T2D risk with gene variants of IGF2BP2(rs4402960),SLC30A8(rs13266634),CAPN10(rs3792267)and HHEX(rs1111875).Moreover,no association was found between FTO gene variants(rs9939609 and rs8050136)and T2D risk.However,T2D risk was found to be significantly associated with obesity(P=0.002,OR=2.22);and with the Waist-to-Hip ratio(n=532,P=1.9×10^(-7),OR=2.4),[among males(n=234,P=1.2×10^(-4),OR=2.0)and females(n=298,P=0.001,OR=6.3)].CONCLUSION:Results confirmed the association of KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398)and CDKN2A/B(rs10811661)gene variants with susceptibility to T2D among Omani Arabs. | Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi | 2015 | World Journal of Diabetes2015，6，2： | 3 |
| 3 | Coxiella burnetii,the causative agent of Q fever in Saudi Arabia:molecular detection from camel and other domestic livestock显示文摘Objective:To detect Coxiella burnetii(C.burnetii)DNA in clinical specimens from camel,goats,cattle and sheep in the Kingdom of Saudi Arabia.Methods:A total of 367 clinical samples including blood,milk,faeces and urine were collected from different livestock and subjected to PCR amplification using primers which amplify transposon-like region and transposase gene.Results:Positive amplification from both regions was obtained from camel,goats and cattle but not from sheep.A percentage of 10.8%samples yielded positive PCR amplification from both blood and milk,where 15 of 139 blood and 16 of 148 milk samples were positive.Faeces and urine showed higher percentages of positive samples reaching 40.8%and 23.8%respectively.Conclusions:The preferred route of shedding in camel appeared to be the faeces followed by urine,while that of goats appeared to be the faeces and that of the cattle appeared to be the milk. | Osama B.Mohammed Abdulrahman A.Jarelnabi Riyadh S.Aljumaah Mohammed A.Alshaikh Amel O.Bakhiet Sawsan A.Omer Abdulaziz N.Alagaili Mansour F.Hussein | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，9： | 2 |
| 4 | Fetal Left and Right Ventricle Myocardial Performance Index: Defining Normal Values for the Second and Third Trimesters—Single Tertiary Center Experience显示文摘 | Hani Ghawi Salwa Gendi Kiran Mallula Mohammed Zghouzi Nadeen Faza Sawsan Awad | 2013 | Pediatric Cardiology2013，，8： | 2 |
| 5 | Oil spill sorption using carb- onized pith bagasse: trial for practical application显示文摘 | Hussein M Amer A A Sawsan lI | 2008 | International Journal of Environmental Science &Technology2008，5，2： | 1 |
| 6 | Prenylated flavonoids of Erythrina lysistemon grown in Egypt 显示文摘 | Sawsan EM Masouda EA Hala HZ | 2002 | Phytochemistry2002，60，： | 1 |
| 7 | Matrix metalloproteinases in cardiovascular disease显示文摘 | Peter Liu Mei Sun Sawsan Sader | 2006 | Canadian Journal of Cardiology2006，，： | 1 |
| 8 | Oil spill sorption using carbonized pith bagasse: Application of carbonized pith bagasse as loose fiber 显示文摘 | HUSSEIN M AMER A A SAWSAN I I | 2009 | Global NEST Journal2009，11，4： | 1 |
| 9 | A prospective, longitudinal study on patients with trigeminal neuralgia who underwent radiofrequency thermocoagalation of the Gasserian ganglion 显示文摘 | Zakrzewska JM Sawsan J Bulman JS | 1999 | Pain1999，79，： | 1 |
| 10 | A unified approach to molecular epidemiology investigations: tools and patterns in California as a case study for endemic shigellosis 显示文摘 | Sawsan AN Woutrina A M Barbara AB | 2009 | BMC Infect Dis2009，9，： | 1 |
| 11 | C-flavonoidal glycosides from Erythrina caffra flowers 显示文摘 | El-Masry Sawsan Hammoda Hala M Radwan Mohamed M | 2010 | Nat Prod Sci2010，16，4： | 1 |
| 12 | Oil Spill Sorption Using Carbonized Pith Bagasse: Trial for Practical Application 显示文摘 | Hussein M Amer A A Sawsan I I | 2008 | International Journal of Environmental Science and Technology2008，5，2： | 1 |
| 13 | Asymptotic Behavior and Oscillations of Second Order Differential Equations with Deviating Argument显示文摘 | Sawsan M. Aziz A.H. Nasr | 1996 | Journal of Mathematical Analysis and Applications1996，，2： | 1 |
| 14 | Chronic treatment with coenzyme Q10 reverses restraint stress in duced anhedonia and enhances brain mitochondrial respiratory chain and creatine kinase activities in rats 显示文摘 | Sawsan Aboul-Fotouh | 2013 | BehavPharmacol2013，24，7： | 1 |
| 15 | The Status of Medicinal Plants in Jordan显示文摘 | Sawsan Atallah Oran | 2014 | Journal of Agricultural Science and Technology(A)2014，4，6： | 1 |
| 16 | Segmentation and classification of whiteb lood cells显示文摘 | Bikhet Sawsan F Darwish Ahmed M Tolba Hany A | 2000 | IEEE Transactions on Medical Imageing2000，19，3： | 1 |
| 17 | Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: role of iNOS and VEGF显示文摘 | Sawsan A Zaitone Noha M | 2012 | Eur J Pharmacol2012，691，13： | 1 |
| 18 | The use of C-reactive protein in predicting bacterial co-infection in children with bronchio|itis显示文摘 | Mohamad Fares MD Sawsan Mourad MD Mariam Rajab MD | 2011 | North American J Med Sci2011，3，3： | 1 |
| 19 | Atomic force microscopy study of the growth mechanism of gibbsite crystals显示文摘 | SAWSAN J F GORDON M P MANIJEH M R | 2004 | Journal of Chemical Physics2004，6，14： | 1 |
| 20 | Advanced stage endometriosis in adolescents and young women显示文摘 | Noam Smorgick Sawsan As-Sanie Courtney A Marsh | 2014 | Journal of Pediatric and Dolescent Gyne- colo~2014，27，6： | 1 |
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