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| 1 | Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1显示文摘AIM To investigate the role of suppressor of cytokine signaling 1(SOCS1)in regulating MET-mediated invasive potential of hepatocellular carcinoma(HCC)cells.METHODSStable derivatives of mouse(Hepa1-6)and human(hep3B,Hep G2)HCC cell lines expressing SOCS1or control vector were evaluated for their ability to migrate towards hepatocyte growth factor(HGF)in the transwell migration assay,invade extracellular matrix in response to HGF stimulation in a 3-D invasion assay by confocal microscopy,and to undergo anchorageindependent proliferation in semisolid agar.Following intravenous and intrasplenic inoculation into NOD.scid.gamma mice,the ability of Hepa cells to form othotopic tumors was evaluated.Following HGF stimulation of Hepa and Hep3B cells,expression of proteins implicated in epithelial-to-mesenchymal transition was evaluated by western blot and qR T-PCR.RESULTS SOCS1 expression in mouse and human HCC cells inhibited HGF-induced migration through matrigel.In the 3-D invasion assay,HGF stimulation induced invasion of HCC cells across type-Ⅰcollagen matrix,and SOCS1expression significantly reduced the depth of invasion.SOCS1 expression also reduced the number and size of colonies formed by anchorage-independent growth in semisolid agar.Following intravenous inoculation,control Hepa cell formed large tumor nodules that obliterated the liver whereas the SOCS1-expressing Hepa cells formed significantly smaller nodules.Tumors formed by SOCS1-expressing cells showed reduced phosphorylation of STAT3 and ERK that was accompanied by reduced levels of MET protein expression.HGF stimulated Hepa cells expressing SOCS1 showed increased expression of E-cadherin and decreased expression of EGR1,SNAI1and ZEB1.Comparable results were obtained with Hep3B cells.SOCS1 expressing HCC cells also showed reduced levels of EGR1 and SNAI1 transcripts.CONCLUSION Our findings indicate that loss of SOCS1-dependent control over epithelial-to-mesenchymal transition may contribute to MET-mediated migration,invasion and metastatic growth of HCC. | Yirui Gui Md Gulam Musawwir Khan Diwakar Bobbala Claire Dubois Sheela Ramanathan Caroline Saucier Subburaj Ilangumaran | 2017 | World Journal of Gastroenterology2017，23，36： | 3 |
| 2 | Modeling Arctic Ocean heat transport and warming episodes in the 20th century caused by the intruding Atlantic Water显示文摘This study investigates the Arctic Ocean warming episodes in the 20th century using both a high-resolution coupled global climate model and historical observations .The model,with no flux adjustment,reproduces well the Atlantic Water core temperature(AWCT) in the Arctic Ocean and shows that four largest decadal-scale warming episodes occurred in the 1930s,70s,80s,and 90s,in agreement with the hydrographic observational data.The difference is that there was no pre-warming prior to the 1930s episode,while there were two pre-warming episodes in the 1970s and 80s prior to the 1990s,leading the 1990s into the largest and prolonged warming in the 20th century.Over the last century,the simulated heat transport via Fram Strait and the Barents Sea was estimated to be,on average,31.32 TW and 14.82 TW,respectively,while the Bering Strait also provides 15.94 TW heat into the western Arctic Ocean.Heat transport into the Arctic Ocean by the Atlantic Water via Fram Strait and the Barents Sea correlates significantly with AWCT(C=0.75 ) at 0- lag.The modeled North Atlantic Oscillation(NAO) index has a significant correlation with the heat transport(C=0.37).The observed AWCT has a significant correlation with both the modeled AWCT(C=0.49) and the heat transport(C=0.41). However,the modeled NAO index does not significantly correlate with either the observed AWCT(C=0.03) or modeled AWCT(C=0.16) at a zero-lag,indicating that the Arctic climate system is far more complex than expected. | Wang Jia Jin Meibing Jun Takahashi Tatsuo Suzuki Igor V Polyakov Kohei Mizobata Moto Ikeda Fancois J. Saucier Markus Meier | 2008 | Chinese Journal of Polar Science2008，19，2： | 2 |
| 3 | Enriched environment and effect of age on ischemic brain damage 显示文摘 | Saucier DM Yager JY Armstrong EA | 2007 | Brain Res2007，1170，1： | 1 |
| 4 | Antimicrobial effects of selected plant essential oils on the growth of a pseudomonas putida strain isolated from meat显示文摘 | Oussalah M Caillet S Saucier L | 2006 | Meat Sci2006，73，2： | 1 |
| 5 | Microbiological and biochemical characteristics of ground beef as affected by gamma irradiation, food additives and edible coating film 显示文摘 | Quattara B Giroux G Myefsah R Smoragiewicz W Saucier E Borsa J | 2002 | Radiation Physics and Chemistry2002，63，： | 1 |
| 6 | Ultrasonography versus chest radiography after chest tube removal for the detection of pnemnothorax 显示文摘 | Saucier S Motyka C Killu K | 2010 | AACN Adv Crit Care2010，21，1： | 1 |
| 7 | Mitogenic activity of estrogens in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or phosphatidylinositol 3-kinase 显示文摘 | Gabcn A M Saucier C Bedin M | 2004 | Mol Endoerinol2004，18，11： | 1 |
| 8 | Gabl is required for cell cycletransition, cell proliferation, and transformation induced by an on-cogenic met receptor 显示文摘 | Mood K Saucier C Bong YS | 2006 | Mol Biol Cell2006，17，9： | 1 |
| 9 | Copigmentafion in model wine solutions: occurrence and relation to wine aging 显示文摘 | Mirabel M Saucier C Guerra C Glories Y | 1999 | American Journal of Enology and Viticulture1999，50，2： | 1 |
| 10 | Biotransformation enzyme activities in the olfactory organ of rainbow trout (Oncorhynchus mykiss). Immunocytochemical localization of cytochrome P4501A1 and its induction by β-naphthoflavone显示文摘 | G. Monod D. Saucier E. Perdu-Durand M. Diallo J. -P. Cravedi L. Astic | 1994 | Fish Physiology and Biochemistry1994，，6： | 1 |
| 11 | Rapid fractionation of grape seed proanthocyanidins 显示文摘 | Cedric Saucier Marie Mirabel Freddy Daviaud | 2001 | J Agric Food Chem2001，49，： | 1 |
| 12 | First evidence of acetaldehyde-flavanol condensation products in red wine显示文摘 | SAUCIER C LITTLE D GLORIES Y | 1997 | American Journal of Enology and Viticulture1997，48，3： | 1 |
| 13 | Homozygosity at the dopamine DRD3 receptor gene in cocainedependence显示文摘 | Comings DE Gonzalez N Wu S Saucier G Johnson P Verde R | 1999 | Mol Psychiatry1999，4，5： | 1 |
| 14 | A 3-D coupled ice-ocean model applied to Hudson Bay, Canada: the seasonal cycle and time-dependent climate response to atmospheric forcing and runoff显示文摘 | SAUCIER F J DIONNE J | 1998 | J Geophys Res1998，103，27： | 1 |
| 15 | Air void stability(Part V): Temperature, general analysis, and performance index显示文摘 | SAUCIER F PIGEON M CAMERON G | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 16 | Hierarchical Subcomponents of the Big Five Personality Factors:A Cross-language Replication 显示文摘 | Saucier G Ostendorf F | 1999 | Journal of Personality and Social Psychology1999，76，4： | 1 |
| 17 | Textural Analysis of Disordered Materials with Multifractals显示文摘 | Antoine Saucier Jiri Muller | 1999 | Physica A1999，267，： | 1 |
| 18 | Critieal thinking outcomes of computer-assisted instruction versus written nursing process显示文摘 | Saucier B L Stevens K R Williams G B | 2000 | Nurs Heal Care Perspect2000，21，3： | 1 |
| 19 | Considerations in gravel pack design 显示文摘 | Saucier R J | 1974 | Journal of Petroleum Technology1974，，： | 1 |
| 20 | Structural particle board reinforced with glass fiber-progress in its development显示文摘 | Saucier J R Holman J A | 1975 | Forest Products Journal1975，25，9： | 1 |
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