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| 1 | Isolation, identification, Pb(Ⅱ) biosorption isotherms and kinetics of a lead adsorbing Penicillium sp. MRF-1 from South Korean mine soil显示文摘A heavy metal contaminated soil sample collected from a mine in Chonnam Province of South Korea was found to be a source of heavy metal adsorbing biosorbents.Chemical analyses showed high contents of lead(Pb) at 357 mg/kg and cyanide(CN) at 14.6 mg/kg in the soil.The experimental results showed that Penicillium sp.MRF-1 was the best lead resistant fungus among the four individual metal tolerant fungal species isolated from the soil.Molecular characterization of Penicillium sp.MRF-1 was determined using ITS regions sequences.Effects of pH,temperature and contact time on adsorption of Pb(II) by Penicillium sp.MRF-1 were studied.Favorable conditions for maximum biosportion were found at pH 4 with 3 hr contact time.Biosorption of Pb(II) gradually increased with increasing temperature.Efficient performance of the biosorbent was described using Langmuir and Freundlich isotherms.Adsorption kinetics was studied using pseudo first-order and pseudo second-order models.Biosorbent Penicillium sp.MRF-1 showed the maximum desorption in alkali conditions.Consistent adsorption/desorption potential of the biosorbent in repetitive cycles validated the efficacy of it in large scale.SEM studies given notes on surface modification of fungal biomass under metal stress and FT-IR results showed the presence of amino groups in the surface structure of the biosorbent.In conclusion,the new biosorbent Penicillium sp.MRF-1 may potentially be used as an inexpensive,easily cultivatable material for the removal of lead from aqueous solution. | Natarajan Velmurugan Grim Hwang Muthuswamy Sathishkumar Tae Kie Choi Kui-Jae Lee Byung-Taek Oh Yang-Soo Lee | 2010 | Journal of Environmental Sciences2010，22，7： | 7 |
| 2 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 3 | Chikungunya infection:A potential re-emerging global threat显示文摘Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described. | Shanmugaraj Bala Murugan Ramalingam Sathishkumar | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 5 |
| 4 | A comparative study of sequential vs.simultaneous type Ⅰ tympanoplasty in patients with bilateral chronic otitis media-Mucosal type显示文摘Background:Patients with bilateral chronic otitis media-mucosal type have been conventionally treated with sequential tympanoplasty.Bilateral simultaneous tympanoplasty is usually not preferred because of the theoretical risk of iatrogenic sensorineural hearing loss.With the advent of modern surgical instruments and surgical techniques,the risk is expected to be lower.This study compares the clinical outcomes in typeⅠtympanoplasty performed simultaneously and sequentially.Materials&methods:This randomized prospective study was carried out in a tertiary care hospital between August 2015 and July 2017.A total of 30 patients were divided into two groups of 15 each.This study analyzed the graft uptake,pure tone audiogram findings pre-and post-operatively,duration of surgery and number of hospital visit for each patient and the outco mes were co mpared between both the groups.Result:Patients undergoing bilateral simultaneous tympanoplasty had significantly lesser mean duration of surgery and number of hospital visits than the patients undergoing sequential tympanoplasty.Graft uptake and postoperative wound infections were similar in both the groups.Postoperative hearing improvement was significantly better in the bilateral simultaneous tympanoplasty group.However,further studies are needed to authenticate this observation.None of the patients had a postoperative deterioration of hearing or sensorineural hearing loss.Conclusion:Bilateral simultaneous tympanoplasty is not only feasible but also better than sequential tympanoplasty,especially in terms of operating time,follow-up and overall financial implications on the patient. | Preethi Umamaheswaran Sanjeev Mohanty Vinoth Manimaran Sathishkumar Jayagandhi Shiva Priya Jeyabalakrishnan | 2020 | Journal of Otology2020，15，2： | 3 |
| 5 | DNA Barcode ITS Effectively Distinguishes the Medicinal Plant Boerhavia diffusa from Its Adulterants显示文摘Boerhavia diffusa (B. diffusa), also known as Punarnava, is an indigenous plant in India and an important component in traditional Indian medicine. The accurate identification and collection of this medicinal herb is vital to enhance the drug's efficacy and biosafety. In this study, a DNA barcoding technique has been applied to identify and distinguish B. diffusa from its closely-related species. The phylogenetic analysis was carried out for the four species of Boerhavia using barcode candidates including nuclear ribosomal DNA regions ITS, ITS1, ITS2 and the chloroplast plastid gene psbA-trnH. Sequence alignment revealed 26% polymorphic sites in ITS, 30% in ITS1, 16% in ITS2 and 6% in psbA-trnH, respectively. Additionally, a phylogenetic tree was constructed for 15 species using ITS sequences which clearly distinguished B. diffusa from the other species. The ITS1 demonstrates a higher transition/transversion ratio, percentage of variation and pairwise distance which differentiate B. diffusa from other species of Boerhavia. Our study revealed that ITS and ITS1 could be used as potential candidate regions for identifying B. diffusa and for authenticating its herbal products. | Dhivya Selvaraj Dhivya Shanmughanandhan Rajeev Kumar Sarma Jijo C. Joseph Ramachandran V. Srinivasan Sathishkumar Ramalingam | 2012 | Genomics, Proteomics & Bioinformatics2012，10，6： | 2 |
| 6 | An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents显示文摘An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent. | Sangaraiah Nagarajan Poovan Shanmugavelan Murugan Sathishkumar Ramasamy Selvi Alagusundaram Ponnuswamy Hariharan Harikrishnan Vellasamy Shanmugaiah | 2014 | Chinese Chemical Letters2014，25，3： | 2 |
| 7 | Standardization of the age root stocks for top wedge grafting in tamarind显示文摘 | Sathishkumar V Mokashi A N Ramakriahna V | 2003 | Madras Agric J2003，90，7： | 1 |
| 8 | Binding affinity of pro- amhocyanidin from waste Pinus radiata bark onto proline- rich bovine achilles tendon collagen type 1显示文摘 | Ku CS Sathishkumar M Mun SP | 2007 | Chemo- sphere2007，67，8： | 1 |
| 9 | Preparation of PEI-coated bacterial biosorbent in water solution:Optimization of manufacturing conditions using response surface methodology显示文摘 | Mao J Kwak I S Sathishkumar M | 2011 | Bioresource Technology2011，102，： | 1 |
| 10 | Biocrystallizationof silver and gold ions by inactive cell filtrate of Rhizopusstolonifer显示文摘 | Binupriya A R Sathishkumar M Yun S I | 2010 | Colloids and Surfaces B:Biointerfaces2010，79，2： | 1 |
| 11 | Corynebacterium glutamicum-mediated crystallization of silver ions through sorption and reduction processes 显示文摘 | SNEHA K SATHISHKUMAR M MAO J | 2010 | Chern Eng J2010，162，3： | 1 |
| 12 | Epidemiology, clinical features and transmission of re-emerging arboviral infection chikungunya显示文摘A number of re-emerging and emerging infectious diseases including chikungunya, West Nile, yellow fever, Zika, dengue, Japanese encephalitis, and others have increased in recent years, which threaten the public health across the globe. Chikungunya is a neglected re-emerging arboviral infection caused by chikungunya virus. Arboviral infections such as chikungunya, Zika and dengue have similar epidemiology, transmission cycles and clinical symptoms, which makes it difficult to diagnose these three infections. Moreover, there is no commercial vaccine or licensed therapy available for chikungunya infection, thus causing severe burden worldwide. Vector control may reduce the disease risk; however, this remains a challenge due to many factors including, but not limited to, evolution of insecticide resistance in mosquitoes, gaps in vector control tools, urbanization, environmental and demographic changes. Effective integrated vector control strategies and surveillance measures along with affordable vaccine development or anti-viral therapy are essential to control the infection. In this review, we discuss the epidemiology of mosquito-borne infection chikungunya which has re-emerged as an international concern in recent decades. | Balamurugan Shanmugaraj Ashwini Malla Sathishkumar Ramalingam | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，4： | 1 |
| 13 | Rat model of polymicrobial infection,immunity,and alveolar bone resorption in periodontal disease显示文摘 | Kesavalu L Sathishkumar S Bakthavatchalu V | | 0，，： | 1 |
| 14 | CoFe2O4/TiO2 nanocatalysts for the photocatalytic degradation of Reactive Red 120 in aqueous solutions in the presence and absence of electron acceptors 显示文摘 | Sathishkumar P Mangalaraja R V Anandan S | 2013 | Chemical Engineering Journal2013，220，： | 1 |
| 15 | Reducing the seat vibration of vehicle by semi active force control technique显示文摘 | Sathishkumar P Jancirani J John D | 2014 | Journal of Mechanical Science and Technology2014，28，2： | 1 |
| 16 | Preparation of PEI-coated bacterial biosorbent in water solution: optimization of manufacturing conditions using response surface methodology显示文摘 | Mao J Kwak I S Sathishkumar M | 2011 | Bioresource Technology2011，102，2： | 1 |
| 17 | Rabbit articular cartilage defects treated by allogenic chondrocyte transplantation 显示文摘 | Boopalan PR Sathishkumar S Kumar S | 2006 | Int Orthop2006，30，5： | 1 |
| 18 | Arsenic removal fromgroundwater by pret reated waste tea fungal biomass显示文摘 | Murugesan G Sathishkumar M Swaminathan K | 2006 | BioresourceTechnology2006，97，3： | 1 |
| 19 | In vitro antioxidant activity of Barleria noctiflora L. f.显示文摘 | Sangilimuthu Alagar Yadav Anitha Jabamalai Raj R Sathishkumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，2： | 1 |
| 20 | Biodegradation of crude oil by individual bacterial straias and a mixed bacterial con- soainm isolated from hydrocarbon contaminated areas 显示文摘 | Sathishkumar M Binupfiya A R Ho B S | 2008 | Clean2008，36，1： | 1 |
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