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| 1 | Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis显示文摘AIM To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis(CHP).METHODS Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters(plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin(HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three months.RESULTS Both groups were comparable at baseline. Three months after non surgical periodontal therapy(NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was-0.056 ± 0.10 and-1.66 ± 6.04 respectively, which was significant between case and control group(P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT(P < 0.05).CONCLUSION This study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP. | Rosamma Joseph Meera Sasikumar Jerry Mammen M G Joseraj Chandni Radhakrishnan | 2017 | World Journal of Diabetes2017，8，5： | 7 |
| 2 | Antidiabetic effect of Merremia emarginata Burm.F.in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antidiabetic property of Merremia emarginata(M.emarginata) Burm.F.plant in streptozotocin induced diabetic rats.Methods:The dose dependent effects of 28 days oral treatment with methanol extract(100,200 and 400 mg/kg) from the plant oi M.emarginata on blood glucose level,body weight,insulin,total hemoglobin,glycosylated haemoglobin(HbA1C),total protein,serum urea,serum creatinine and carbohydrate metabolizing enzymes were evaluated in streptozotocin induced diabetic rats.Histology of pancreas was also studied.Results:A significant decrease in blood glucose,serum urea and serum creatinine and significant increase in body weight,insulin and protein level were observed in diabetic rats treated with M.emarginata.Treatment with M.emarginata resulted in a significant reduction of HbAlC and an increase in total hemoglobin level.The activities of carbohydrate metabolizing enzymes such as hexokinase were significantly increased whereas glucose-6phosphatase,fructose-1,6-bisphosphatase were significantly decreased by the administration of M.emarginata in diabetic rats.Histology of diabetic rats treated with M.emarginata showed the pancreatic β-cells regeneration.Conclusions:These findings suggest that M.emarginata has potent antidiabetic activity in streptozotocin induced diabetic rats. | G Rajiv Gandhi P Sasikumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 4 |
| 3 | Development of polymer electrolyte membrane fuel cell stack显示文摘 | DHATHATHREYAN K S SRIDHAR P SASIKUMAR G | 1999 | International Journal of Hydrogen Energy1999，24，11： | 1 |
| 4 | The many roles of the eukaryotic elongation factor 1 complex显示文摘 | Sasikumar A N Perez W B Kinzy T G | | 0，，04： | 1 |
| 5 | A Genetic Algorithm Approach for Solving a Closed Loop Supply Chain Model: A Case of Battery Recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 6 | Dependence of optimum Nation content in catalyst layer on platinum loading显示文摘 | SASIKUMAr G IHM J M RYU H | 2004 | Power Source2004，132，12： | 1 |
| 7 | Dependence of optimum nation content in catalyst layer on platinum loading 显示文摘 | Sasikumar G Ihm J W Ryu H | 2004 | Journal of Power Sources2004，132，： | 1 |
| 8 | Optimum nafion content in PEM fuel cell electrodes显示文摘 | Sasikumar G | 2004 | Electrochim Acta2004，50，2： | 1 |
| 9 | A genetic algorithm approach for solving a closed loop supply chain model: A case of battery recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Model- ling2010，34，3： | 1 |
| 10 | Dependence of optimum Nafion content in catalyst layer on platinum loading 显示文摘 | Sasikumar G Ibm J W Ryu H | 2004 | Journal of Power Sources2004，132，12： | 1 |
| 11 | Optimum Nation content in PEM fuel cell electrodes显示文摘 | Sasikumar G Ihm J W Ryu H | 2004 | Electrochim Acta2004，50，23： | 1 |
| 12 | Monitoring trace metal contaminants in green mussel, Perna viridis from the coastal waters of Karnataka, southwest coast of India 显示文摘 | Sasikumar G Krishnakumar P K Bhat G S | 2006 | Archives of Environmental Contamination and Toxicology2006，51，： | 1 |
| 13 | A genetic algorithm approach for solving a closed loop supply chain model: A case of battery recycling显示文摘 | KANNAN G SASIKUMAR P DEVIKA K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 14 | 显示文摘 | Dhathathreyan K S Sridhar P Sasikumar G | 1999 | International Journal of Hydrogen Energy1999，24，11： | 1 |
| 15 | A genetic algorithm approach for solving a closed loop supply chain model: a case of battery recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 16 | A genetic algorithm approach for solving a closed loop supply chain model:A case of battery recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 17 | Development of polymer electrolyte membrane fuel cell stack 显示文摘 | K S Dhathathreyan P Sridhar G Sasikumar K K Ghosh G Velayutham N Rajalakshmi C K Subramaniam M Raja K Ramya | 1999 | International Journal of Hydrogen Energy1999，24，： | 1 |
| 18 | Evaluation of platinum catalyzed MEAs for PEM fuel cell applications显示文摘 | Pethaiah S S Kalaignan G P Sasikumar G | 2011 | Solid Statelonics2011，190，1： | 1 |
| 19 | A heuristic based approachto vehicle routing model for Third Party Reverse Logisticsprovider显示文摘 | Sasikumar P Kannan G Haq A N | 2009 | International Journal of Services Technology andManagement2009，12，1： | 1 |
| 20 | Dependence of optimum Nation content in catalyst layer on platinum loading显示文摘 | Sasikumar G Ihm J W Ryu H | 2004 | J Power Sources2004，132，12： | 1 |
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