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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Chronic inflanmmatory sclerosis of the pancraeasan autonomous pancreatic disease显示文摘 | Sarles H Sarles JC Muratore R Guien C | 1961 | Am J Dig Dis1961，6，： | 1 |
| 3 | Chronic inflammatorysclerosis of the pancreas-an autonomous pancreatic disease 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 4 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，，6： | 1 |
| 5 | Chronic inflammatory scle- rosis of the pancreas-an autonomous pancreatic disease? 显示文摘 | Sarles H Sarles Jc Muratore R | 1961 | Am J Dig Dis1961，6，7： | 1 |
| 6 | In vivo effect of 13 Leu motilin activity of the rabbit sphincter of oddi显示文摘 | Sarles JC Delecourt P Devaux MA | 1981 | Horm Metab Res1981，13，6： | 1 |
| 7 | Anatomical study of chronic pancreatitis of the adult显示文摘 | Sarles H Muratore R Sarles JC | 1961 | Sem Hop1961，37，： | 1 |
| 8 | Chronic inflammatory sclerosis of the pancreas:an autonomous pancreatic diseases显示文摘 | Sarles H Sarles JC Muratore R | | 0，，： | 1 |
| 9 | Effect of somatostatin on the rabbit oddi's sphincter in vivo interrelation of somatostatin and cholecystokinin显示文摘 | Adami GF Leandri R Sarles JC | 1986 | Gastroenterol Clin Biol1986，10，2： | 1 |
| 10 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease? 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 11 | Endorectal repair of rectocele显示文摘 | Arnaud A Selezneff | 1989 | Int J Colorectal Dis1989，4，： | 1 |
| 12 | Chronic inflammatorysclerosis of the pancreas-an autonomous pancreatic disease? 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 13 | Chronic inflammatory sclerosis of the pancreas and autoimmune pancreatic disease显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，，6： | 1 |
| 14 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease? 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，7： | 1 |
| 15 | Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease?显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 16 | 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 17 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease显示文摘 | SARLES H SARLES JC MURATORE R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 18 | Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease?显示文摘 | Sarles H Sarles JC Muratore R | 1961 | AmJ Dig Dis1961，6，： | 1 |
| 19 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease显示文摘 | SARLES H SARLES JC MURATORE R | | 0，，： | 1 |
| 20 | Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease显示文摘 | Sarles H Sarles JC Muratore R | | 0，，： | 1 |
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