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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 3 | Chronic inflammatory sclerosis of the pancreas—An autonomous pancreatic disease?显示文摘 | Henri Sarles Jean-Claude Sarles Raymond Muratore Claude Guien | 1961 | The American Journal of Digestive Diseases1961，，7： | 2 |
| 4 | 胰腺炎的定义及分类显示文摘本世纪初曾认为急性胰腺炎和慢性胰腺炎是两种不同的病,以后从慢性胰腺炎患者切除的胰腺组织中发现常有急性病变合并存在,Comfort 等认为慢性胰腺炎起源于急性胰腺炎的反复发作;而与之对立的假设则为慢性胰腺炎可能是急性、频繁反复发作性胰腺炎的一个原因。Cattell 等认为急性出血性胰腺炎与进展钙化性胰腺炎之间存在着过渡。 | Sarles H 吴云林 | 1992 | 国外医学(消化系疾病分册)1992，12，2： | 2 |
| 5 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 6 | Wilson disease,IgA glomerulonephritis andvascular purpura:An incidental association显示文摘 | Sarles J Durand JM Scheiner C | 1993 | Arch Fr Pediatr1993，50，6： | 1 |
| 7 | Successful medical treatment of severely decompensated Wilson disease显示文摘 | Santos Silva EE Sarles J Buts JP | 1996 | J Pediatr1996，128，2： | 1 |
| 8 | Chronic inflanmmatory sclerosis of the pancraeasan autonomous pancreatic disease显示文摘 | Sarles H Sarles JC Muratore R Guien C | 1961 | Am J Dig Dis1961，6，： | 1 |
| 9 | Alcoholism and pancreatitis 显示文摘 | SARLES H | 1971 | Scand J Gastroen- terol1971，6，3： | 1 |
| 10 | da Vinci-assisted robotic partial nephrectomy :technique and results at a mean of 15 months of fol- low-up显示文摘 | Kaul S Laungani R Sarle R | 2007 | Eur Ure12007，51，1： | 1 |
| 11 | Synthesis,characterization,thermal properties of a series of stearic acid esters as novel solid-liquid phase change materials显示文摘 | Sarl A Bicer A Karsipekli A | 2009 | Materials Letters2009，63，1314： | 1 |
| 12 | Chronic inflammatorysclerosis of the pancreas-an autonomous pancreatic disease 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，6，： | 1 |
| 13 | Vattikuti institute pros- tatectomy: a single-team experience of 100 eases 显示文摘 | Menon M Shrivastava A Sarle R | 2003 | J Endou- rol2003，17，： | 1 |
| 14 | Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease 显示文摘 | Sarles H Sarles JC Muratore R | 1961 | Am J Dig Dis1961，，6： | 1 |
| 15 | Capric-myristic acid/expanded perlite composite as form-stable phase change material for latent heat thermal ener- gy storage显示文摘 | Karaipokli A Sarl A | 2008 | Renewable Energy2008，33，12： | 1 |
| 16 | Chronic inflammatory scle- rosis of the pancreas-an autonomous pancreatic disease? 显示文摘 | Sarles H Sarles Jc Muratore R | 1961 | Am J Dig Dis1961，6，7： | 1 |
| 17 | A contempirary overview of periphe ral nerve research from the Cleveland Clinic microsurgery laboratory显示文摘 | SIEMIONOW M SARL A | 2004 | Neurol Res2004，26，5： | 1 |
| 18 | In vivo effect of 13 Leu motilin activity of the rabbit sphincter of oddi显示文摘 | Sarles JC Delecourt P Devaux MA | 1981 | Horm Metab Res1981，13，6： | 1 |
| 19 | Anatomical study of chronic pancreatitis of the adult显示文摘 | Sarles H Muratore R Sarles JC | 1961 | Sem Hop1961，37，： | 1 |
| 20 | Chronic inflammatory sclerosis of the pancreas:an autonomous pancreatic diseases显示文摘 | Sarles H Sarles JC Muratore R | | 0，，： | 1 |
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