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| 1 | Acute stress-induced impairment of spatial memory is associated with decreased expression of neural cell adhesion molecule in the hippocampus and prefrontal cortex 显示文摘 | Sandi C Woodson J C Haynes V F | 2005 | Biol Psychiatry2005，57，8： | 1 |
| 2 | Regulation of p53 activity in nuclear bodies by a specific PML isoform显示文摘 | Fogal V Gostissa M Sandy P | 2000 | EMBO J2000，19，： | 1 |
| 3 | Reactive oxygen gene network of plants 显示文摘 | Ron M Sandy V Martin G | 2004 | Trends in Plant Science2004，9，10： | 1 |
| 4 | The effects of different orthodontieap- plianees upon microbial eommunities 显示文摘 | Ireland AJ Soro V Sandy JR | 2014 | Orthod Craniofae Res2014，17，2： | 1 |
| 5 | Effects of transforming growth factor beta-1 on growth-regulation genes in tumor- derived human oral keratinocytes显示文摘 | Paterson IC Patel V Sandy JR | 1995 | Br J Cancer1995，72，： | 1 |
| 6 | Effects of transforming growth factor beta-1 on growth-regulatlon genes in tumor-derived human oral keratinocytes显示文摘 | Paterson IC Patel V Sandy JR | 1995 | Br J Cancer1995，72，： | 1 |
| 7 | Streamlining sample preparation and gas chromatography-tandem mass spectrometry analysis of multiple pesticide residues in tea显示文摘 | CAJKA T SANDY C BACHANOVA V | 2012 | Analytica Chimica Acta2012，743，： | 1 |
| 8 | Regulation of p53 activity in nuclear bodies by a specific PML isoform显示文摘 | FOGAL V GOSTISSA M SANDY P | 2000 | EMBO J2000，19，： | 1 |
| 9 | Regulation of p53 activity in nuclear bodies by a specific PML isoform 显示文摘 | Fogal V Gostissa M Sandy P | 2000 | EMBO J2000，19，22： | 1 |
| 10 | Repurposing space ina science and engineering library : Considerations for a successfuloutcome 显示文摘 | Sandy J H Krishnamurthy M Scalfani V F | 2014 | The Journal of Academic Librarianship2014，40，3： | 1 |
| 11 | Regulation of p53 activity in nuclear bodies by a specific PML isoform显示文摘 | FOGAL V GOSTISSA M SANDY P | 2000 | EMBO J2000，19，22： | 1 |
| 12 | Immunologi- cal toolbox available for in situ exploration of pectic ho- mogalacturonan and its modifying enzymes in fruits and vegetables and their derived food products显示文摘 | Evelien V Stefanie C Sandy V B | 2012 | Innova- tive Food Science and Emerging Technologies2012，15，： | 1 |
| 13 | Efficacy of sodium hyaluranate in the management of chemical and radiation cystitis显示文摘 | SOMMARIVA ML SANDI SD CERIANI V | 2010 | Minerva Urol Nefrol2010，62，： | 1 |
| 14 | Influence of high-pressure-low- temperature treatments on fruit and vegetable quality related enzymes显示文摘 | Sandy V B Inge M Iel V D P | 2006 | Eu- ropean Food Research and Technology2006，223，4： | 1 |
| 15 | Regulation of p53 activity in nuclear bodies by a specific PML isoform显示文摘 | Fogal V Gostissa M Sandy P | 2000 | EMBO J2000，19，： | 1 |
| 16 | No benefit of flat head positioning in early moderate-severe acute ischaemic stroke: a HeadPoST study subgroup analysis显示文摘background Although the Head Positioning in acute Stroke Trial(HeadPoST)showed no effect of the flat head position(FP;vs sitting up head position(SUP))on functional outcome,we hypothesised that it could still offer benefits if commenced early in those with acute ischaemic stroke(AIS)of at least moderate severity.Methods Subgroup analysis of HeadPoST in participants with National Institutes of Health Stroke Scale(NIHSS)scores≥7,≥10 and≥14,randomised to FP or SUP<4.5 hours of AIS onset on functional outcomes defined by a shift in scores on the modified Rankin scale(mRS)and death/disability(mRS scores 3-6),and any cardiovascular serious adverse event.Logistic regression analyses were undertaken adjusted for study design and baseline risk factors.results There was no significant differential treatment effect in patient subgroups defined by increasing baseline NIHSS scores:adjusted OR and 95%CI for ordinal shift and binary(3-6)mRS scores:for NIHSS≥7(n=867)0.92(0.67 to 1.25)and 0.74(0.52 to 1.04);NIHSS≥10(n=606)0.80(0.58 to 1.10)and 0.77(0.49 to 1.19);NIHSS≥14(n=378)0.82(0.54 to 1.24)and 1.22(0.69 to 2.14).Conclusions Early FP had no significant effect in patients with moderate-severe AIS. | Alejandro M Brunser Menglu Ouyang Hisatomi Arima Pablo M Lavados Thompson Robinson Paula Munoz-Venturelli Veronica V Olavarria Laurent Billot Marre L Hackett Lili Song Sandy Middleton Octavio Pontes-Neto Tsong-Hai Lee Caroline Watkins Craig S Anderson | 2020 | Stroke & Vascular Neurology2020，5，4： | 0 |
| 17 | Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein显示文摘Precision medicine is defined by the administration of drugs based on the tumor's particular genetic characteristics. It is developing quickly in the field of cancer therapy. For example, KRAS, NRAS and BRAF genetic testing demonstrates its efficiency for precision medicine in colorectal cancer(CRC). Besides for these well-known mutations, the purpose of performing larger genetic testing in this pathology is unknown. Recent reports have shown that using the poly ADP ribose polymerase(PARP) inhibitor olaparib in patients with homologous repair enzyme deficiency gave positive clinical results in breast, ovarian and prostate cancers. We have reported here the cases of 2 patients with multi-treated metastatic CRC who underwent somatic and constitutional exome analyses. The analyses revealed a loss of function mutation in a homologous repair enzyme resulting in the loss of heterozygosity for both patients(Check2 for the first patient and RAD51 C for the second one). Both patients were treated with off-label usage of olaparib. While the first patient showed clinical benefit, reduction of carcinoembryonic antigen tumor marker and radiologic response, the second patient quickly presented a progression of the tumor. Additional genetic analyses revealed a frameshift truncating mutation of the TP53BP1 gene in the patient who progressed. Interestingly, deficiency in TP53BP1 was previously described to confer resistance to olaparib in mice breast cancer models. Our findings suggest that exome analysis may be a helpful tool to highlight targetable mutations in CRC and that olaparib may be efficient in patients with a homologous repair deficiency. | Francois Ghiringhelli Corentin Richard Sandy Chevrier Frédérique Végran Romain Boidot | 2016 | World Journal of Gastroenterology2016，22，48： | 0 |
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