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| 1 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 2 | Interleukin-15 enhances innate and adaptive immune reponses to bloodstage malaria infection in mice显示文摘 | Ing R Gros P Stevenson M M | 2005 | Infect Immun2005，73，5： | 1 |
| 3 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 4 | The effects of trust and interde pendenee on relationship commitment: A trans-Athantie study 显示文摘 | INGE GEYSKENSA JAN-BENEDICT E M STEENKAMPB A LISA K SCHEERC | 1996 | Int J Res Marketing1996，13，4： | 1 |
| 5 | Switching from entecavir to PegIFN alfa-2a in patients with HBeAg-positive chronic hepatitis B: a randomised open label trial (OSST trial)显示文摘 | ing Q Han M Sun Y | 2014 | J Hepatol2014，61，4： | 1 |
| 6 | Genetic epidemiological studies of early-onset deafness in the US school-age population显示文摘 | MARAZITA M L PLOUGHMAN L M RAWL INGS B | 1993 | Am J Med Genet1993，46，： | 1 |
| 7 | Ni adsorption and Ni-AI LDH precipitation in a sandy aquifer: An experimental and mechanistic modeling study 显示文摘 | INGE C TEMMINGHOFF E J M | 2011 | Environmental Pollution2011，159，3： | 1 |
| 8 | Lignin peroxidase of Phanerochate chrysosporium显示文摘 | M ing T Kirk T K | 1988 | Methods in Enzymology1988，161，1： | 1 |
| 9 | A meta - analysis of satisfaction in marketing channel relationships 显示文摘 | INGE GEYSKENS JAN - BENEDICT E M STEENKAMP NIR- MALYA KUMAR | 1999 | Journal of Marketing Research1999，，36： | 1 |
| 10 | Videocinematography of fresh and cryopreserved embryos : a retrospective analysis of embryonic mor- phology and implantation 显示文摘 | Cohen J Inge KL Suzman M | 1989 | Fertil Steril1989，51，5： | 1 |
| 11 | Technical accuracy of a neuronavigation system measured with a high-precision mechanical micromanipulator显示文摘 | Kaus M Ing D Sporer T | | 0，，： | 1 |
| 12 | Gestational weigth Gain and Pregnancy Outcomes in 481 Obese glucose-tolerant women显示文摘 | Dorte M Per Ovesen H enn ing BN | | 0，，9： | 1 |
| 13 | The Leading Edge显示文摘 | Gulunay N Magesan M Roende H H Gather flatten- ing | 2007 | 26 (12) : 1538 - 15432007，26，12： | 1 |
| 14 | Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene显示文摘 | Inge T Caroline M Sven T | 2001 | Biochemical and Biophisical Research Communication2001，287，1： | 1 |
| 15 | Videocinematography of fresh and cryopreserved embryos: a retrospective analysis of embryonic morphology and implantation显示文摘 | Cohen J Inge KL Suzman M | 1989 | Fertil Steril1989，51，5： | 1 |
| 16 | ASMBS pediatric committee best practice guidelines显示文摘 | Michalsky M Reichard K Inge T | 2012 | Surg Obes Relat Dis2012，8，1： | 1 |
| 17 | Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation 显示文摘 | Ing R Segura M Thawani N | 2006 | J Immunol2006，176，： | 1 |
| 18 | The Effects of Trust and Interdependence on Relationship Commitment: A Trans- Atlantic Study 显示文摘 | Geyskens Inge Jan - Bendlct E M Steenkamp Lisa K Scheer Nirmalya Kumar | 1996 | International Journal of Research in Marketing1996，，13： | 1 |
| 19 | Bifurcation analysis of an impact oscillator with a one-sided elas- tic constraint near grazing显示文摘 | Ing J Pavlovskaia E Wiercigroch M | 2010 | Physica D2010，239，6： | 1 |
| 20 | Videocinematography of fresh and cryopreserved embryos: a retrospective analysis of embryonic morphology and implantation显示文摘 | Cohen J Inge KL Suzman M | 1989 | Fertil Steril1989，51，5： | 1 |
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