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| 1 | Metabolic positron emission tomography imaging of cancer:Pairing lipid metabolism with glycolysis显示文摘The limitations of fluorine-18 fluorodeoxy-D-glucose(FDG)in detecting some cancers has prompted a longstandin search for other positron emission tomography(PET tracers to complement the imaging of glycolysis i oncology, with much attention paid to lipogenesis base on observations that the production of various lipid an lipid-containing compounds is increased in most cancers Radiolabeled analogs of choline and acetate have now been used as oncologic PET probes for over a decade showing convincingly improved detection sensitivit over FDG for certain cancers. However, neither cholin nor acetate have been thoroughly validated as lipogeni biomarkers, and while acetyl-Co A produced from acetat is used in de-novo lipogenesis to synthesize fatty acids acetate is also consumed by various other syntheti and metabolic pathways, with recent experimenta observations challenging the assumption that lipogenesi is its predominant role in all cancers. Since tumor detected by acetate PET are also frequently detected b choline PET, imaging of choline metabolism might serv as an alternative albeit indirect marker of lipogenesis particularly if the fatty acids produced in cancer cell are mainly destined for membrane synthesis throug incorporation into phosphatidylcholines. Aerobic glycolysi may or may not coincide with changes in lipid metabolism resulting in combinatorial metabolic phenotypes that ma have different prognostic or therapeutic implications Consequently, PET imaging using dual metabolic tracers in addition to being diagnostically superior to imagin with individual tracers, could eventually play a greate role in supporting precision medicine, as efforts t develop small-molecule metabolic pathway inhibitors ar coming to fruition. To prepare for this advent, clinical an translational studies of metabolic PET tracers must g beyond simply estimating tracer diagnostic utility, and aim to uncover potential therapeutic avenues associated wit these metabolic alterations. | Sandi A Kwee John Lim | 2016 | World Journal of Radiology2016，8，11： | 2 |
| 2 | What is small island sustainable development about显示文摘 | Sandy A Kerr | 2005 | Ocean & Coastal Management2005，，48： | 1 |
| 3 | Mammalian RNAi: a practical guide 显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 4 | Mammalian RNAi: a practical guide显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 5 | Leptomeningeal metastasis:a comparison of gadolinium enhanced MR and contrast-enhanced CT of the brain显示文摘 | Chamberlain M Sandy A Press G | 1990 | Neurol1990，40，： | 1 |
| 6 | Activation of heat shock and antioxidant responses by the natural product eelastrol: transcriptional signaturesof a thiol-targeted molecule显示文摘 | Trott A James DW Sandy DW | 2003 | Mol Biol Cell2003，19，3： | 1 |
| 7 | RNAi as an experimental and therapeutic tool to study and regulate physiological and disease processes显示文摘 | Dillon CP Sandy P Nencioni A | 2005 | Annu Rev Physiol2005，67，3： | 1 |
| 8 | Platinum nanoc-lusters immobilized on polymer-clay nanocomposite films显示文摘 | Carrado Kathleen A Sandi Giselle Kizilel Riza | 2005 | Applied ClayScience2005，30，2： | 1 |
| 9 | Mammalian RNS a practical guide 显示文摘 | Sandy P Ventura A Jacks T | 2005 | Bio Techniques2005，39，2： | 1 |
| 10 | Supercritical fluid extraction of isoflavones from soybean flour显示文摘 | Rostagno Mauricio A Araujo Julio M A Sandi Delcio | 2002 | Food Chemistry2002，78，1： | 1 |
| 11 | Effect of the silica precursor on the conductivity of hectorite-derived polymer nanocomposites显示文摘 | Giselle Sandi Riza Kizilel Kathleen A Carrado | 2005 | ElectrochimicaActa2005，50，19： | 1 |
| 12 | Arylamine N-acetyltransferases-of mice,men and microorganisms显示文摘 | Upton A Johnson N Sandy J | 2001 | Trends Pharmacol Sci2001，22，3： | 1 |
| 13 | Mammalian RNAi: a practical guide 显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 14 | Small angle neutron scattering characterization of the porous structure of carbons prepared using inorganic templates显示文摘 | Thiyagarajan P Carrado K A | 1999 | Chem Mater1999，11，2： | 1 |
| 15 | What is small island sustainable development about 显示文摘 | SANDY A KERR | 2005 | Ocean & Coastal Management2005，48，78： | 1 |
| 16 | Mild optic nerve hypoplasia with retinal venous tortuosity in Aarskog (facial-digital-genital) syndrome显示文摘 | Jogiya A Sandy C | 2005 | Ophthalmic Genet2005，26，3： | 1 |
| 17 | Supercritical fluid extraction of isoflavones from soybean flour显示文摘 | Maur??cio A Rostagno Júlio M.A Araújo Delcio Sandi | 2002 | Food Chemistry2002，，1： | 1 |
| 18 | Mammalian RNAi:a practical guide显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 19 | Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems显示文摘 | Sandi C Cordero MI Ugolini A | | 0，，09： | 1 |
| 20 | Natural adhesives from novel sources显示文摘 | SANDI A VEGA J ALVARADO P | 2008 | Technical Papers2008，1，1： | 1 |
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