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您的检索式：作者名="Sandra Fonseca"
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| 1 | DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis显示文摘DE-ETIOLATED 1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS 1(COP1)are two essential repressors of Arabidopsis photomorphogenesis.These proteins can associate with CULLIN4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELONGATED HYPOCOTYL 5(HY5),thereby controlling multiple gene-regulatory networks.Despite extensive biochemical and genetic analyses of their multi-subunit complexes,the functional links between DET1 and COP1 have long remained elusive.Here,we report that DET1 associates with COP1 in vivo,enhances COP1-HY5 interaction,and promotes COP1 destabilization in a process that dampens HY5 protein abundance.By regulating its accumulation,DET1 avoids HY5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic transcription factor PHYTOCHROME-INTERACTING FACTOR 3.Accordingly,ectopic HY5 chromatin enrichment favors local gene repression and can trigger fusca-like phenotypes.This study therefore shows that DET1-mediated regulation of COP1 stability tunes down the HY5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability. | Esther Canibano Clara Bourbousse Marta Garcia-Leon Borja Garnelo Gomez Lea Wolff Camila Garcia-Baudino Rosa Lozano-Duran Fredy Barneche Vicente Rubio Sandra Fonseca | 2021 | Molecular Plant2021，14，6： | 2 |
| 2 | Quercetin in Lyotropic Liquid Crystalline Formulations: Physical, Chemical and Functional Stability显示文摘 | Fabiana T. M. C. Vicentini Rúbia Casagrande Waldiceu A. Verri Jr. Sandra R. Georgetti M. Vitória L. B. Bentley Maria J. V. Fonseca | 2008 | AAPS PharmSciTech2008，，2： | 1 |
| 3 | Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity显示文摘 | Suziy de M. Bandeira Glaucevane da S. Guedes Lucas José S. da Fonseca André S. Pires Daniel P. Gelain José Claudio F. Moreira Luíza A. Rabelo Sandra Mary L. Vasconcelos Marília Oliveira F. Goulart Felipe Dal-Pizzol | 2012 | Oxidative Medicine and Cellular Longevity2012，，： | 1 |
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