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| 1 | Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells显示文摘Aim: To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation, migration and invasion, as well as its effect on the expression of urokinase plasmonogen activator (uPA), its receptor (uPAR) and matrix metalloproteinases (MMP)-2 and -9 in normal and malignant prostate cells. In addition, we tested whether saposin C can activate p42/44 and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) signal transduction pathways of the mitogen-activated protein kinase (MAPK) superfamily. Methods: We employed Western blot analysis, phospho-specific antibodies, cell proliferation assay, reverse transcriptase-polymerase chain reaction,in vitro kinase assays and migration and invasion to determine the effect of saposin C on various biological behaviors of prostate stromal and cancer cells. Results: Saposin C, in a cell type-specific manner, upregulates uPA/uPAR and immediate early gene c-Jun expression, stimulates cell proliferation, migration and invasion and activates p42/44 and SAPK/JNK MAPK pathways in prostate stromal and cancer cells. Normal prostate epithelial cells were not responsive to saposin C treatment in the above studies. Conclusion: Saposin C functions as a multipotential modulator of diverse biological activities in prostate cancer and stromal cells. These results strongly suggest that saposin C functions as a potent growth factor for prostatic cells and may contribute to prostate carcinogenesis and/or the development of hormone-refractory prostate cancer. | Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten | 2005 | Asian Journal of Andrology2005，7，2： | 7 |
| 2 | Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis显示文摘 | Sandhoff K Harzer K | 2013 | J Neurosci2013，33，25： | 1 |
| 3 | Topology of glycosphingolipid degradation显示文摘 | SANDHOFF K KOLTER T | 1996 | Trends Cell Biol1996，6，： | 1 |
| 4 | Transcriptional re- pression of the rat steroidogenic acute regulatory ( StAR ) protein gene by the AP-1 family member c-Fos 显示文摘 | Shea-Eaton W Sandhoff TW Lopez D | 2002 | Mol Cell Endocrinol2002，188，12： | 1 |
| 5 | Gangliosides and gangliosido- ses: principles of molecular and metabolic pathogenesis 显示文摘 | Konrad Sandhoff Klaus Harzer | 2013 | The Journal of neuroscience : the official journal of the Society for Neu- roscience2013，33，10： | 1 |
| 6 | Histone deacetylase inhibitor selectively induces P21^WAFI expression and gene-associated histone acetylation 显示文摘 | Richon V M Sandhoff T W Ritkind R A | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 7 | Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation显示文摘 | Richon VM Sandhoff TW Rifkind RA | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 8 | Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation显示文摘 | RICHON V M SANDHOFF T W RIFKIND R A | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 9 | Minireview: combinatorial ganglioside biosynthesis 显示文摘 | Kolter T Proia RL and Sandhoff K | 2002 | J Biol Chem2002，277，25： | 1 |
| 10 | Gangliosides and gangliosidoses:principles of molecular and metabolic pathogenesis显示文摘 | Konrad Sandhoff Klaus | | 0，，： | 1 |
| 11 | Combinatorial ganglioside biosynthesis显示文摘 | Koher T Proia RL Sandhoff K | 2002 | J Biol Chem2002，277，25： | 1 |
| 12 | Prostaglandin F2α reduces steroidogenic acute regulatory (StAR) protein messenger ribonucleic acid expression in the rat ovary显示文摘 | Todd W. Sandhoff Mark P. McLean | 1996 | Endocrine1996，，2： | 1 |
| 13 | Histone deacetylase inhibitor selectively induces P21WAF1 expression and gene associated histone acetylation显示文摘 | Richon VM Sandhoff TW Rifkind RA | 2000 | PNAS2000，97，10： | 1 |
| 14 | Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by sterodgogenic factor 1显示文摘 | Hales DB | 1998 | Endocrinology1998，139，： | 1 |
| 15 | Histone deacetylase inhibitor selectively induces p21waf1 expression and gene-associated histone acetylation显示文摘 | Richon VM Sandhoff TW Rifkind RA | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 16 | Histone deacetylase inhibitor selectively induces p21WAFI expression and gene-associated histone acetylation 显示文摘 | Richon VM Sandhoff TW Ritkind RA | 2000 | Proc Nail Acad Sci U S A2000，97，10： | 1 |
| 17 | Lipid Management in Patients With Coronary Artery Disease by a Clinical Pharmacy Service in a Group Model Health Maintenance Organization 显示文摘 | Olson KL Rasmussen J Sandhoff BG | 2005 | ACC Current Journal Review2005，14，5： | 1 |
| 18 | Histone deacetylase inhibitor selectively induces p21WAFl expression and geneassociated histone acetylation显示文摘 | Richon VM Sandhoff TW Rifkind RA | | 0，，： | 1 |
| 19 | Cancer: Killing from the inside 显示文摘 | Saftig P Sandhoff K | 2013 | Nature2013，502，7471： | 1 |
| 20 | Purification and characterization of recombinant human acid sphingomyelinase expressed in insect Sf21 cells显示文摘 | Lansmann S Bartelsen LO Sandhoff K | 2000 | Methods Enzymol2000，311，14： | 1 |
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