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73篇 您的检索式:作者名="Sandhir"
    题名 作者 年代 出处 被引量
1Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal显示文摘Diabetes mellitus(DM), a metabolic disorder is a major orchestra influencing brain and behavioral responses via direct or indirect mechanisms. Many lines of evidence suggest that diabetic patients apparently face severe brain complications, but the story is far from being fully understood. Type 2 diabetes, an ever increasing epidemic and its chronic brain complications are implicated in the development of Alzheimer's disease(AD). Evidences from clinical and experimental studies suggest that insulin draws a clear trajectory from the peripheral system to the central nervous system. This review is a spot light on striking pathological, bio-chemical, molecular and behavioral commonalities of AD and DM. Incidence of cognitive decline in diabetic patients and diabetic symptoms in AD patients has brought the concept of brain diabetes to attention. Brain diabetes reflects insulin resistant brain state with oxidative stress, cognitive impairment, activation of various inflammatory cascade and mitochondrial vulnerability as a shared footprint of AD and DM. It has become extremely important for the investigators to understand the patho-physiology of brain complications in diabetes and put intensive pursuits for therapeutic interventions. Although, decades of research have yielded a range of molecules with potential beneficial effects, but they are yet to meet the expectations.Rajat Sandhir Smriti Gupta 2015World Journal of Diabetes2015,6,12:8
2Curcumin supplementation improves mitoehondrial and behavioral deficits in experimental model of chronic epilepsy 显示文摘Kaur H Bal A Sandhir R 2014Pharmacol Biochem Behav2014,125,:1
3Anti atherogenic effect of chro mium picolinate in streptozotocin induced experimental diabetes 显示文摘Sundaram B Singhal K Sandhir R 2013J Diabetes2013,5,1:1
4Modulation of dopaminergic system and neurobehavioral functions in delayed neuropathy induced by organophosphates显示文摘Masoud A Kiran R Sandhir R 2011Toxicol Mech Methods2011,21,1:1
5Hyperglycemia-induced alterations in syn-aptosomal membrane fluidity and activity of membrane bound enzymes:Benefi-cial effect of N-acetylcysteine supplementation显示文摘Kamboj SS Chopra K Sandhir R 0,,:1
6Effects on antioxidant status of liver following atrazine exposure and its at- tenuation by vitamin E显示文摘Singh M Sandhir R Kiran R 2011Experimental and Toxico- logic Pathology2011,63,3:1
7Protective effect of ly- copene on oxidative stress and cognitive decline in ro- tenone induced model of Parkinson' s disease 显示文摘Kaur H Chauhan S Sandhir R 2011Neurochem Res2011,6,8:1
8Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury 显示文摘Sandhir R Gregory E He Y Y 2011Neurochem Res2011,36,5:1
9Age-dependent response of CCAAT/enhancer binding proteins {ollowing traumatic brain injury in mice显示文摘Sandhir R Berman NE 2010Neurochem Int2010,56,:1
10Protective effect of ]yeopene on oxida- tive stress and cognitive decline in rotenone induced model of Parkin- son: Disease显示文摘Kaur H Chauhan S Sandhir R 2011Neuroehem Res2011,36,8:1
11Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats 显示文摘Kamboj SS Sandhir R 2011Mitochondrion2011,11,1:1
12Chromium picolinate attenua- tes hyperglycemia-induced oxidative stress in streptozotocin- induced diabetic rats显示文摘Sundaram B Aggarwal A Sandhir R 2013J Trace Elem Med Biol2013,27,2:1
13Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats显示文摘Masoud A Kiran R Sandhir R 2009Cell Mol Neurobiol2009,29,:1
14Hyperglycemia -induced al-terationsinsynaptosomal membrane fluidity and activity o1 mem-brane bound enzymes:beneficial effect of N -acetylcysteine supplementation显示文摘KamboJ SS Chopra K Sandhir R 2009Neuroscience2009,162,:1
15Role of the estrogen receptors GRP 30 and ER-alpha in peripheral sensitization:relevance to trigeminal pain disorders in women显示文摘Liverman CS Brown JW Sandhir R 0,,07:1
16Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Par- kinson q disease 显示文摘Kaur H Chauhan S Sandhir R 2011Neurochem Res2011,36,8:1
17Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease显示文摘Kaur H Chauhan S Sandhir R 2011Neurochem Res2011,36,:1
18Potential antiamnesic agents 显示文摘Piplani P Rani A Sandhir R Pharm Chemistry0,2009,:1
19N-acetylcysteine inhibits hyperglycemia-induced oxidative Stress and apoptosis markers in diabetic neuropathy显示文摘Kamboj S S Vasishta R K Sandhir R 2010J Neurochem2010,112,1:1
20Protective Effect of Lycopeneon Oxidative Stress and Cognitive Decline in Rotenone InducedModel of Parkinson * s Disease显示文摘Kaur H Chauhan S Sandhir R 2011Neurochem Res2011,36,8:1
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