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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Total phenolic content,in vitro antioxidant activity and chemical composition of plant extracts from semiarid Mexican region显示文摘Objective:To determine the extraction suitable conditions of total phenolic content(TPC) by heat-reflux system,antioxidant activities and HPLC characterization of the aqueous-ethanolic extracts of Jatropha dioica(J.dioica)(Dragon's blood).Flourensia cernua(F.cernua)(Tar bush).Eucalyptus camaldulensis(E.camaldulensis)(Eucalyptus) and Turnera diffusa(T.diffusa)(Damiana).Methods:TPC was evaluated by the well-known colorimetric assay using FolinCiocalteu reagent.The antioxidant activities were assayed by three methods based on scavenging of DPPH,ABTS and by lipid oxidation inhibition.The chemical composition of the extracts obtained was subject to HPLC analysis.Results:TPC in the plant extracts ranged from 2.3 to14.12 mg gallic acid equivalents/g for J.dioica and E.camaldulensis,respectively.The plant extracts of F.cernua,E.camaldulensis and T.diffusa showed similar strong antioxidant activities on scavenging of DPPH and lipid oxidation inhibition.In contrast,J.dioica extracts had lowest potential antioxidant in three assays used.HPLC assay showed the presence of several phenolic compounds in the extracts used.Conclusions:The results obtained suggest that F.cernua,E.camaldulensis and T.diffusa are potential sources to obtain bioactive phenolic compounds with high antioxidant properties which can be used in the factories as antioxidant agents or for treatments in diseases. | Jorge E.Wong-Paz Juan C.Contreras-Esquivel Raúl Rodríguez-Herrera María L.Carrillo-Inungaray Lluvia I.López Guadalupe V.Nevárez-Moorillón Cristóbal N.Aguilar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，2： | 3 |
| 3 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 4 | Synchronous electrogastrographic and manometric study of the stomach as an esophageal substitute显示文摘AIM: To investigate the electric and contractile mechanisms involved in the deranged function of the transposed stomach in relation to the course of the symptoms and the changes in contractile and electrical parameters over time.METHODS: Twenty-one patients after subtotal esophagectomy and 18 healthy volunteers were studied.Complaints were compiled by using a questionnaire, and a symptom score was formed. Synchronous electrogastrography and gastric manometry were performed in the fasting state and postprandially.RESULTS: Eight of the operated patients were symptomfree and 13 had symptoms. The durations of the postoperative periods for the symptomatic (9.1±6.5 mo)and the asymptomatic (28.3±8.8 mo) patients were significantly different. The symptom score correlated negatively with the time that had elapsed since the operation. The percentages of the dominant frequency in the normogastric, bradygastric and tachygastric ranges differed significantly between the controls and the patients.A significant difference was detected between the power ratio of the controls and that of the patients. The occurrence of tachygastria in the symptomatic and the symptom-free patients correlated negatively both with the time that had elapsed and with the symptom score. There was a significant increase in motility index after feeding in the controls, but not in the patients. The contractile activity of the stomach increased both in the controls and in the symptom-free patients. In contrast, in the group of symptomatic patients, the contractile activity decreased postprandially as compared with the fasting state.CONCLUSION: The patients' post-operative complaints and symptoms change during the post-operative period and correlate with the parameters of the myoelectric and contractile activities of the stomach. Tachygastria seems to be the major pathogenetic factor involved in the contractile dysfunction. | Ferenc Izbéki Tibor Wittmann Sándor (O|')dor Balázs Botos (A|')ron Altorjay | 2005 | World Journal of Gastroenterology2005，11，8： | 2 |
| 5 | Curcumin supplementation improves mitoehondrial and behavioral deficits in experimental model of chronic epilepsy 显示文摘 | Kaur H Bal A Sandhir R | 2014 | Pharmacol Biochem Behav2014，125，： | 1 |
| 6 | Influence of hBN content on mechanical and tribological properties of Si3N4/ BN ceramic composites 显示文摘 | KovalcKov A Balko J Bal zsi C | 2014 | J Eur Ceram Soc2014，34，： | 1 |
| 7 | A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules显示文摘 | Rajagopal D Bal V Mayor S George A Rath S | 2006 | Eur J Immunol2006，36，4： | 1 |
| 8 | Nigrostriatal neuronal death following chronic dichlorvos exposure:crosstalk between mitochondrial impairments,or synuclein aggregation,oxidative damage and behavioral changes 显示文摘 | Binukumar BK Bal A Kandimalla R J | 2010 | Mol Brain2010，3，： | 1 |
| 9 | Inflammatory neurodegeneration mediated by nitricoxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity显示文摘 | Bal Price A Brown GC | 2001 | Neurosci2001，21，： | 1 |
| 10 | Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischemia in rats显示文摘 | De Cristóbal J Moro AM Dávalos A | | 0，，02： | 1 |
| 11 | Long-term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosisinsights from the SZEGED Study显示文摘 | Nemes A Balázs E Csanády M | 2009 | Clin Physiol Funct Imaging2009，29，6： | 1 |
| 12 | Mitochondrial energy metabolism impairment and liver dysfunction following chronic exposure to dichlorvos 显示文摘 | Binukumar BK Bal A Kandimalla RJ | 2010 | Toxicology2010，270，23： | 1 |
| 13 | Antimierobial peptides: current status and therapeutic potential 显示文摘 | KOCZULLA A R BALS R | 2003 | Drugs2003，63，4： | 1 |
| 14 | Fatal descending necrotizing mediastinitis secondary to acute suppurative thyroiditis developing in an apparently healthy woman 显示文摘 | PEREIRA O PRASAD D S BAL A M | 2010 | Thyroid2010，20，5： | 1 |
| 15 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 16 | An architecture for making recommendations to courseware authors using association rule mining and collaborative filtering显示文摘 | Enrique García Cristóbal Romero Sebastián Ventura Carlos de Castro | 2009 | User Modeling and User-Adapted Interaction2009，，1： | 1 |
| 17 | Data mining in course management systems:Mcodle case study and tutorial显示文摘 | Sebastia'n Ventura Enrique Garc 'a | 2007 | Computers & Education2007，51，： | 1 |
| 18 | Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults显示文摘 | Cassio A Bal MO Orsini LF | 2006 | J Pediatr2006，149，： | 1 |
| 19 | The high-molecular-weight cytochrome c Cyc2 of Acidithiobacillus ferrooxidans is an outer membrane protein显示文摘 | Yarzábal A Brasseur G Ratouchniak J | 2002 | The Journal of Bacteriology2002，184，： | 1 |
| 20 | Antibiotic resistance in Staphylococcus aureus and its relevance in therapy显示文摘 | BAL A M GOULD I M | 2005 | Expert Opin Pharmacother2005，6，13： | 1 |
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