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42篇 您的检索式：作者名="Sander CS"

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	题名	作者	年代	出处	被引量
1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
2	Subtalar fosinn after displaced intra-articular calcaneal fractures: does initial operative treatment matter? Surgical technique 显示文摘	Radnay CS Clare MP Sanders RW	2010	J Bone Joint Surg Am2010，92，11：	1
3	Differential Expression of CYPI A,2B,and 3A Genes in the F344 Rat following Exposure to a Polybrominated Diphenyl Ether Mixture or Individual Components显示文摘	Sanders JM BL Smith CS Black W	2005	Toxicol Sci2005，88，1：	1
4	Gender differences in upper airway compliance during NREM sleep;Role of neck circumference 显示文摘	Rowley JA Sanders CS Zahn BR	2002	J Appl Physiol2002，92，6：	1
5	Subtalar fusion after dis-placed intra-articular calcaneal fractures:does initial opera-tive treatment matter?Surgical technique显示文摘	Radnay CS Clare MP Sanders RW	2010	J Bone Joint SurgAm2010，92，1：	1
6	High-sensitivity C-reactive protein is independently associated with early carotid artery progression in women but not in men:the INVADE Study显示文摘	Sander K Horn CS Briesenick C	2007	Stroke2007，38，11：	1
7	Threatened carotid artery rupture:a complication of radical neck surgery显示文摘	Sanders EM Davis KR Whelan CS	1986	J Surg Oncol1986，33，2：	1
8	Oxidative stress is implicated in the pathogenesis of lichen sclerosus显示文摘	Sander CS Ali I Dean D	2004	Br J Dermatol2004，151，：	1
9	Expression of extracellular matrix protein 1 (ECM1)in human skin is decreased by age and increased upon ultraviolet exposure显示文摘	SANDER CS SERCU S ZIEMER M	2006	Br J Dermatol2006，154，2：	1
10	The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation 显示文摘	Ogawa F Sander CS Hansel A	2006	J Invest Dcrmatol2006，126，：	1
11	Expression of extracellular ma- trix protein I(ECMl)in human skin is decreased by age and in- creased upon ultraviolet exposure显示文摘	Sander CS Sercu S Ziemer M	2006	Br J Dermatol2006，154，2：	1
12	Subtalar fusion after displacedintra-articular calcaneal fractures : does initial operative treatmentmatter 显示文摘	Radnay CS Clare MP Sanders RW	2009	J Bone Joint Surg Am2009，91，3：	1
13	Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis显示文摘	Sander CS Chan g H Hamm F	2004	Iht J Derrflatol2004，43，3：	1
14	Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis显示文摘	Sander CS Chan GH Hamm F		0，，03：	1
15	Differential ex-pression of CYP1A,2B, and 3A genes in the F344 rat fol-lowing exposure to a polybrominated diphenyl ether mixtureor individual components 显示文摘	Sanders JM Burka LT Smith CS	2005	Toxicol Sci2005，88，1：	1
16	Oxidative stress is implicated in the pathogenesis of lichen sclerosus 显示文摘	Sander CS Ali I Dean D	2004	Br J Derraatol2004，151，3：	1
17	High-sensitivity C-reactive protein is independently associated with early carotid artery progression in women but not in men: the INVADE Study 显示文摘	Sander K Horn CS Briesenick C	2007	Stroke2007，38，11：	1
18	Genome-wide map- ping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells显示文摘	Sanders DA Ross-Innes CS Beraldi D	2013	Genome Bio12013，14，1：	1
19	High-sensitivity C - reac- tive protein is independently associated with early carotid artery pro- gression in women but not in men:the INVADE Study显示文摘	Sander K Horn CS Briesenick C	2007	Stroke2007，38，11：	1
20	Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis显示文摘	Sander CS Chang H Hamm F	2004	Int J Dermatol2004，43，：	1

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